Results 31 to 40 of about 1,981,418 (307)

Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding

Cell Reports, 2017
Thiol peroxidases are conserved hydrogen peroxide scavenging and signaling molecules that contain redox-active cysteine residues. We show here that Gpx3, the major H2O2 sensor in yeast, is present in the mitochondrial intermembrane space (IMS), where it ...
Paraskevi Kritsiligkou, Afroditi Chatzi, Georgia Charalampous, Aleksandr Mironov, Jr., Chris M. Grant, Kostas Tokatlidis   +5 more
doaj   +1 more source

Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces [PDF]

, 2018
BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole.
Chiu, Joanna, Gao, Yuan, Leavis, Paul, Li, Qian, Mitchell, G. F., Morgan, Kathleen, Nicholson, Christopher, Porter, Tyrone, Saphirstein, Robert, Singh, Kuldeep, Verwoert, Germaine   +10 more
core   +1 more source

Mitochondrial protein import [PDF]

, 1994
The transport of nuclear-encoded proteins from the cytosol into mitochondria is mediated by targeting (signal) sequences present on precursor forms.
Neupert, Walter, Schwarz, Elisabeth
core   +1 more source

Mitochondrial import receptors for precursor proteins [PDF]

, 1991
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria.
Attardi, Baker, Deshaies, Gillespie, Hartl, Hines, Horwich, Hwang, Kang, Kiebler, Klingenberg, Meyer, Murakami, Murakami, Murakami, Ono, Pain, Pfaller, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Riezman, Roise, Rosenberg, Schnell, Sheffield, So¨llner, So¨llner, Steger, Vestweber, Wickner   +34 more
core   +1 more source

Targeting and Assembly of Components of the TOC Protein Import Complex at the Chloroplast Outer Envelope Membrane

Frontiers in Plant Science, 2014
The translocon at the outer envelope membrane of chloroplasts (TOC) initiates the import of thousands of nuclear encoded preproteins required for chloroplast biogenesis and function. The multimeric TOC complex contains two GTP-regulated receptors, Toc34
Lynn G.L. Richardson, Yamuna D Paila, Steven eSiman, Chen eYi, Matthew D Smith, Danny eSchnell   +5 more
doaj   +1 more source

Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis

Cells, 2022
Peroxisomes host essential metabolic enzymes and are crucial for human health and survival. Although peroxisomes were first described over 60 years ago, their entire proteome has not yet been identified.
Yotam David, Inês Gomes Castro, Eden Yifrach, Chen Bibi, Enas Katawi, Dekel Yahav Har-Shai, Sagie Brodsky, Naama Barkai, Tommer Ravid, Miriam Eisenstein, Shmuel Pietrokovski, Maya Schuldiner, Einat Zalckvar   +12 more
doaj   +1 more source

A Receptor Component of the Chloroplast Protein Translocation Machinery [PDF]

, 1994
The chloroplast outer envelope protein OEP86 functions as a receptor in precursor protein translocation into chloroplasts. Sequence analysis suggests that the precursor of OEP86 is directed to the chloroplast outer envelope by a cleavable, negatively ...
Heemeyer, Frank, Heijne, Gunnar von, Hirsch, Stephan, Muckel, Eva, Soll, Jürgen   +4 more
core   +1 more source

Functional Organization of Sequence Motifs in Diverse Transit Peptides of Chloroplast Proteins

Frontiers in Physiology, 2021
Although the chloroplasts in plants are characterized by an inherent genome, the chloroplast proteome is composed of proteins encoded by not only the chloroplast genome but also the nuclear genome.
Jinseung Jeong, Inhwan Hwang, Dong Wook Lee, Dong Wook Lee   +3 more
doaj   +1 more source

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. [PDF]

, 2017
As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis.
Antkowiak, Mark, Brust-Mascher, Ingrid, Castro, Noemi M, Cheung, Lee, Christensen, Lana N, Huang, Bo, Jao, Li-En, Jiang, Xueer, Mahe, Karan, Ou, Tingyoung, Sepulveda, Guadalupe, Yoon, Daniel   +11 more
core   +2 more sources

Yet another job for the bacterial ribosome

Microbial Cell, 2019
The ribosome is a sophisticated cellular machine, composed of RNA and protein, which translates the mRNA-encoded genetic information into protein and thus acts at the center of gene expression. Still, the ribosome not only decodes the genetic information,
Andrea Origi, Ana Natriashivili, Lara Knüpffer, Clara Fehrenbach, Kärt Denks, Rosella Asti, Hans-Georg Koch   +6 more
doaj   +1 more source