Results 21 to 30 of about 1,399,144 (265)

Targeting of proteins to the Golgi apparatus [PDF]

Glycoconjugate Journal, 1994
The Golgi apparatus maintains a highly organized structure in spite of the intense membrane traffic which flows into and out of this organelle. Resident Golgi proteins must have localization signals to ensure that they are targeted to the correct Golgi compartment and not swept further along the secretory pathway.
Gleeson, PA, Teasdale, RD, Burke, J
openaire   +5 more sources

Targeting and Assembly of Components of the TOC Protein Import Complex at the Chloroplast Outer Envelope Membrane

Frontiers in Plant Science, 2014
The translocon at the outer envelope membrane of chloroplasts (TOC) initiates the import of thousands of nuclear encoded preproteins required for chloroplast biogenesis and function. The multimeric TOC complex contains two GTP-regulated receptors, Toc34
Lynn G.L. Richardson, Yamuna D Paila, Steven eSiman, Chen eYi, Matthew D Smith, Danny eSchnell   +5 more
doaj   +1 more source

Membrane Interactions of the Peroxisomal Proteins PEX5 and PEX14

Frontiers in Cell and Developmental Biology, 2021
Human PEX5 and PEX14 are essential components of the peroxisomal translocon, which mediates import of cargo enzymes into peroxisomes. PEX5 is a soluble receptor for cargo enzymes comprised of an N-terminal intrinsically disordered domain (NTD) and a C ...
Stefan Gaussmann, Stefan Gaussmann, Mohanraj Gopalswamy, Mohanraj Gopalswamy, Maike Eberhardt, Maike Eberhardt, Maren Reuter, Peijian Zou, Peijian Zou, Wolfgang Schliebs, Ralf Erdmann, Michael Sattler, Michael Sattler   +12 more
doaj   +1 more source

Yet another job for the bacterial ribosome

Microbial Cell, 2019
The ribosome is a sophisticated cellular machine, composed of RNA and protein, which translates the mRNA-encoded genetic information into protein and thus acts at the center of gene expression. Still, the ribosome not only decodes the genetic information,
Andrea Origi, Ana Natriashivili, Lara Knüpffer, Clara Fehrenbach, Kärt Denks, Rosella Asti, Hans-Georg Koch   +6 more
doaj   +1 more source

Proteomics Identifies Substrates and a Novel Component in hSnd2-Dependent ER Protein Targeting

Cells, 2022
Importing proteins into the endoplasmic reticulum (ER) is essential for about 30% of the human proteome. It involves the targeting of precursor proteins to the ER and their insertion into or translocation across the ER membrane. Furthermore, it relies on
Andrea Tirincsi, Sarah O’Keefe, Duy Nguyen, Mark Sicking, Johanna Dudek, Friedrich Förster, Martin Jung, Drazena Hadzibeganovic, Volkhard Helms, Stephen High, Richard Zimmermann, Sven Lang   +11 more
doaj   +1 more source

Protein modification and degradation in ferroptosis

Redox Biology
Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox system, encompassing pro-oxidative proteins and antioxidative proteins.
Yuan Wang, Ding Yan, Jinbao Liu, Daolin Tang, Xin Chen   +4 more
doaj   +1 more source

Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting

eLife, 2017
The signal recognition particle (SRP) delivers ~30% of the proteome to the eukaryotic endoplasmic reticulum, or the bacterial plasma membrane. The precise mechanism by which the bacterial SRP receptor, FtsY, interacts with and is regulated at the target ...
Yu-Hsien Hwang Fu, William Y C Huang, Kuang Shen, Jay T Groves, Thomas Miller, Shu-ou Shan   +5 more
doaj   +1 more source

Co-Translational Protein Folding and Sorting in Chloroplasts

Plants, 2020
Cells depend on the continuous renewal of their proteome composition during the cell cycle and in order to replace aberrant proteins or to react to changing environmental conditions.
Fabian Ries, Claudia Herkt, Felix Willmund   +2 more
doaj   +1 more source

Quantitative Proteomics and Differential Protein Abundance Analysis after Depletion of Putative mRNA Receptors in the ER Membrane of Human Cells Identifies Novel Aspects of mRNA Targeting to the ER

Molecules, 2021
In human cells, one-third of all polypeptides enter the secretory pathway at the endoplasmic reticulum (ER). The specificity and efficiency of this process are guaranteed by targeting of mRNAs and/or polypeptides to the ER membrane. Cytosolic SRP and its
Pratiti Bhadra, Stefan Schorr, Monika Lerner, Duy Nguyen, Johanna Dudek, Friedrich Förster, Volkhard Helms, Sven Lang, Richard Zimmermann   +8 more
doaj   +1 more source

Protein-protein interaction network and subcellular localization of the Arabidopsis thaliana ESCRT machinery

Frontiers in Plant Science, 2011
The Endosomal Sorting Complex Required for Transport (ESCRT) consists of several multi-protein subcomplexes which assemble sequentially at the endosomal surface and function in multivesicular body (MVB) biogenesis.
Lynn eRichardson, Alex eHoward, Nicholas eKhuu, Satinder eGidda, Andrew eMcCartney, Brett eMorphy, Robert eMullen   +6 more
doaj   +1 more source