Results 11 to 20 of about 1,399,144 (265)
Deubiquitinase-targeting chimeras for targeted protein stabilization [PDF]
Nature Chemical Biology, 2022 Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we present deubiquitinase-targeting chimeras (DUBTACs), heterobifunctional small molecules consisting of a deubiquitinase recruiter linked to a protein-targeting ligand, to ...
Nathaniel J. Henning +23 more
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Targeting proteins for degradation [PDF]
Nature Chemical Biology, 2009 Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small peptides as part of the adaptive immune response.
Erin K, Schrader +2 more
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Targeting of proteins to mitochondria [PDF]
Biochemical Society Transactions, 2000 A clear picture has emerged over the past years on how a ‘classic’ mitochondrial protein, like subunit IV of cytochrome c oxidase, might be targeted to mitochondria. The targeting and subsequent import process involves the commitment of the TOM (ranslocase in the uter itochondrial membrane) receptor complex on the mitochondrial surface, a TIM ...
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Nature Communications, 2017 The choice between homologous recombination and non-homologous end-joining is largely influenced by cell cycle. Here the authors show that APCCdh1 promotes homologous recombination by removing USP1, allowing polyubiquitinated histones to recruit BRCA1.
Kyungsoo Ha +15 more
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Structures of the scanning and engaged states of the mammalian SRP-ribosome complex
eLife, 2015 The universally conserved signal recognition particle (SRP) is essential for the biogenesis of most integral membrane proteins. SRP scans the nascent chains of translating ribosomes, preferentially engaging those with hydrophobic targeting signals, and ...
Rebecca M Voorhees, Ramanujan S Hegde
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Systematic multi‐level analysis of an organelle proteome reveals new peroxisomal functions
Molecular Systems Biology, 2022 Seventy years following the discovery of peroxisomes, their complete proteome, the peroxi‐ome, remains undefined. Uncovering the peroxi‐ome is crucial for understanding peroxisomal activities and cellular metabolism.
Eden Yifrach +20 more
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Functional Organization of Sequence Motifs in Diverse Transit Peptides of Chloroplast Proteins
Frontiers in Physiology, 2021 Although the chloroplasts in plants are characterized by an inherent genome, the chloroplast proteome is composed of proteins encoded by not only the chloroplast genome but also the nuclear genome.
Jinseung Jeong +3 more
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Journal of Lipid Research, 2014 Accurate protein inventories are essential for understanding an organelle's functions. The lipid droplet (LD) is a ubiquitous intracellular organelle with major functions in lipid storage and metabolism.
Erin Currie +8 more
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Frontiers in Microbiology, 2017 Recently, controllable, targeted proteolysis has emerged as one of the most promising new strategies to study essential genes and otherwise toxic mutations.
Nan Liu +5 more
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Cell Reports, 2017 Thiol peroxidases are conserved hydrogen peroxide scavenging and signaling molecules that contain redox-active cysteine residues. We show here that Gpx3, the major H2O2 sensor in yeast, is present in the mitochondrial intermembrane space (IMS), where it ...
Paraskevi Kritsiligkou +5 more
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