Results 11 to 20 of about 1,447,276 (313)
Targeting proteins for degradation [PDF]
Nature Chemical Biology, 2009 Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small peptides as part of the adaptive immune response.
Erin K, Schrader +2 more
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Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis
Cells, 2022 Peroxisomes host essential metabolic enzymes and are crucial for human health and survival. Although peroxisomes were first described over 60 years ago, their entire proteome has not yet been identified.
Yotam David +12 more
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Functional Organization of Sequence Motifs in Diverse Transit Peptides of Chloroplast Proteins
Frontiers in Physiology, 2021 Although the chloroplasts in plants are characterized by an inherent genome, the chloroplast proteome is composed of proteins encoded by not only the chloroplast genome but also the nuclear genome.
Jinseung Jeong +3 more
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Quantitative estimate of protein-protein interaction targeting drug-likeness
, 2021 The quantification of drug-likeness is very useful for screening drug candidates. The quantitative estimate of drug-likeness (QED) is the most commonly used quantitative drug efficacy assessment method proposed by Bickerton et al.
Takatsugu, Kosugi, Masahito, Ohue
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Post-Translational Membrane Protein Targeting by the Chloroplast Signal Recognition Particle [PDF]
, 2011 Post-translational transport of membrane proteins poses enormous challenges to the cells. The transport factors must accurately select and deliver the cargos to the appropriate target membranes.
Jaru-Ampornpan, Peera
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Targeting of proteins to mitochondria [PDF]
Biochemical Society Transactions, 2000 A clear picture has emerged over the past years on how a ‘classic’ mitochondrial protein, like subunit IV of cytochrome c oxidase, might be targeted to mitochondria. The targeting and subsequent import process involves the commitment of the TOM (ranslocase in the uter itochondrial membrane) receptor complex on the mitochondrial surface, a TIM ...
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Membrane Interactions of the Peroxisomal Proteins PEX5 and PEX14
Frontiers in Cell and Developmental Biology, 2021 Human PEX5 and PEX14 are essential components of the peroxisomal translocon, which mediates import of cargo enzymes into peroxisomes. PEX5 is a soluble receptor for cargo enzymes comprised of an N-terminal intrinsically disordered domain (NTD) and a C ...
Stefan Gaussmann +12 more
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Targeting of proteins to the Golgi apparatus [PDF]
Glycoconjugate Journal, 1994 The Golgi apparatus maintains a highly organized structure in spite of the intense membrane traffic which flows into and out of this organelle. Resident Golgi proteins must have localization signals to ensure that they are targeted to the correct Golgi compartment and not swept further along the secretory pathway.
Gleeson, PA, Teasdale, RD, Burke, J
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The invariant phenylalanine of precursor proteins discloses the importance of Omp85 for protein translocation into cyanelles [PDF]
, 2007 Background Today it is widely accepted that plastids are of cyanobacterial origin. During their evolutionary integration into the metabolic and regulatory networks of the host cell the engulfed cyanobacteria lost their independency.
Schleiff Enrico +21 more
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Structures of the scanning and engaged states of the mammalian SRP-ribosome complex
eLife, 2015 The universally conserved signal recognition particle (SRP) is essential for the biogenesis of most integral membrane proteins. SRP scans the nascent chains of translating ribosomes, preferentially engaging those with hydrophobic targeting signals, and ...
Rebecca M Voorhees, Ramanujan S Hegde
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