Results 31 to 40 of about 1,447,276 (313)

Insights Into the Peroxisomal Protein Inventory of Zebrafish

Frontiers in Physiology, 2022
Peroxisomes are ubiquitous, oxidative subcellular organelles with important functions in cellular lipid metabolism and redox homeostasis. Loss of peroxisomal functions causes severe disorders with developmental and neurological abnormalities.
Maki Kamoshita, Rechal Kumar, Marco Anteghini, Marco Anteghini, Markus Kunze, Markus Islinger, Vítor Martins dos Santos, Vítor Martins dos Santos, Michael Schrader   +8 more
doaj   +1 more source

Targeting the Choroid Plexuses for Protein Drug Delivery

, 2020
Delivery of therapeutic agents to the central nervous system is challenged by the barriers in place to regulate brain homeostasis. This is especially true for protein therapeutics. Targeting the barrier formed by the choroid plexuses at the interfaces of
Anthony M. Snyder, Abbas R. Rizvi, Mark A. Bryniarski, Marilyn E. Morris, Tianjing Ren   +4 more
core   +1 more source

Mitochondrial protein import [PDF]

, 1988
Transport of nuclear-encoded precursor proteins into mitochondria includes proteolytic cleavage of aminoterminal targeting sequences in the mitochondrial matrix. We have isolated the processing activity from Neurospora crassa.
Hawlitschek, Gerhard, Schneider, Helmut, Tropschug, Maximilian, Hartl, Franz-Ulrich, Neupert, Walter, Schmidt, Bernd   +5 more
core   +1 more source

Glucose lowering effect of transgenic human insulin-like growth factor-I from rice: in vitro and in vivo studies

BMC Biotechnology, 2011
Background Human insulin-like growth factor-I (hIGF-I) is a growth factor which is highly resemble to insulin. It is essential for cell proliferation and has been proposed for treatment of various endocrine-associated diseases including growth hormone ...
Sun Samuel SM, Liu Qiao-quan, Lan Lin-lin, Liu Li-zhong, Cheung Stanley CK, Chan Juliana CN, Tong Peter CY   +6 more
doaj   +1 more source

The C-terminus of Bienertia sinuspersici Toc159 contains essential elements for its targeting and anchorage to the chloroplast outer membrane

Frontiers in Plant Science, 2014
Most nucleus-encoded chloroplast proteins rely on an N-terminal transit peptide (TP) as a post-translational sorting signal for directing them to the organelle.
Shiu-Cheung eLung, Matthew D Smith, Kyle eWeston, William eGwynne, Nathan eSecord, Simon Dich Xung Chuong   +5 more
doaj   +1 more source

Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint [PDF]

, 2021
Removal of the membrane-tethering signal peptides that target secretory proteins to the endoplasmic reticulum is a prerequisite for proper folding.
Sub Cellular Protein Chemistry, Quandte, Matthias, Land, Aafke, McCaul, Nicholas, Sanders, Rogier W., Crooks, Ema T., Bontjer, Ilja, Binley, James M., van Zadelhoff, Guus, Braakman, Ineke, Cellular Protein Chemistry   +10 more
core   +1 more source

Binding of chloroplast signal recognition particle to a thylakoid membrane protein substrate in aqueous solution and delineation of the cpSRP43–substrate interaction domain [PDF]

, 2011
A cpSRP [chloroplast SRP (signal recognition particle)] comprising cpSRP54 and cpSRP43 subunits mediates the insertion of light-harvesting proteins into the thylakoid membrane. We dissected its interaction with a full-length membrane protein substrate in
Colin Robinson, Johnson, AE, Arthur E. Johnson, Iris Holdermann, Robinson, C, Sinning, Irmgard, Holdermann, I, Peter Cain, Cain, Peter, Robinson, Colin, Johnson, Arthur E, Sinning, I, Holdermann, Iris, Irmgard Sinning, Cain, P, Johnson, Arthur E.   +15 more
core   +1 more source

Protein modification and degradation in ferroptosis

Redox Biology
Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox system, encompassing pro-oxidative proteins and antioxidative proteins.
Yuan Wang, Ding Yan, Jinbao Liu, Daolin Tang, Xin Chen   +4 more
doaj   +1 more source

Supramolecular Chemistry Targeting Proteins

Journal of the American Chemical Society, 2017
The specific recognition of protein surface elements is a fundamental challenge in the life sciences. New developments in this field will form the basis of advanced therapeutic approaches and lead to applications such as sensors, affinity tags, immobilization techniques, and protein-based materials.
Sam van Dun, Christian Ottmann, Lech-Gustav Milroy, Luc Brunsveld   +3 more
openaire   +2 more sources

Lipid droplet targeting domains of adipophilin

Journal of Lipid Research, 2003
Adipophilin (ADPH), a prominent protein component of lipid storage droplets (LSDs), is postulated to be necessary for the formation and cellular function of these structures.
James L. McManaman, William Zabaronick, Jerome Schaack, David J. Orlicky   +3 more
doaj   +1 more source