Results 41 to 50 of about 1,447,276 (313)

An Interplay between Mitochondrial and ER Targeting of a Bacterial Signal Peptide in Plants

Plants, 2023
Protein targeting is essential in eukaryotic cells to maintain cell function and organelle identity. Signal peptides are a major type of targeting sequences containing a tripartite structure, which is conserved across all domains in life.
Tatiana Spatola Rossi, Verena Kriechbaumer   +1 more
doaj   +1 more source

Copper deprivation reprograms antioxidant defense to suppress ferroptosis via SLC7A11

Redox Biology
Copper is an essential trace element that governs diverse cellular functions and influences cell fate. However, how cells adapt to copper deprivation remains poorly understood.
Qian Xue, Ziyuan Chen, Jiao Yang, Kaixuan Ren, Xiaofen Li, Xi Chen, Ding Yan, Yuan Wang, Daolin Tang, Jinbao Liu, Xin Chen   +10 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Protein Targeting to the Bacterial Cytoplasmic Membrane [PDF]

, 1999
Proteins that perform their activity within the cytoplasmic membrane or outside this cell boundary must be targeted to the translocation site prior to their insertion and/or translocation.
Fekkes, Peter, Fekkes, Peter,, Driessen, Arnold J.M.,, Driessen, Arnold J.M.   +3 more
core  

To Decipher the Mycoplasma hominis Proteins Targeting into the Endoplasmic Reticulum and Their Implications in Prostate Cancer Etiology Using Next-Generation Sequencing Data

Molecules, 2018
Cancer was initially considered a genetic disease. However, recent studies have revealed the connection between bacterial infections and growth of different types of cancer.
Mohammed Zakariah, Shahanavaj Khan, Anis Ahmad Chaudhary, Christian Rolfo, Mohamed Maher Ben Ismail, Yousef Ajami Alotaibi   +5 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Protease-activatable collagen targeting based on protein cyclization

, 2010
Threading collagen through a protein needle: The collagen-binding protein CNA35 operates by wrapping itself around the collagen triple helix. By connecting the N and C termini through an MMP recognition sequence, a dual-specific MMP-sensitive collagen ...
Monika Breurken, Lempens, E.H.M., Edith H. M. Lempens, Merkx, M., Breurken, M., Maarten Merkx   +5 more
core   +1 more source

Pay32p of the Yeast Yarrowia lipolytica Is an Intraperoxisomal Component of the Matrix Protein Translocation Machinery [PDF]

, 1995
Pay mutants of the yeast Yarrowia lipolytica fail to assemble functional peroxisomes. One mutant strain, pay32-1, has abnormally small peroxisomes that are often found in clusters surrounded by membranous material.
Rachubinski, Richard A., Szilard, Rachel K., Rachubinski, Richard A.,, Titorenko, Vladimir I.,, V I Titorenko, R A Rachubinski, Titorenko, Vladimir I., Rachel K. Szilard, M Veenhuis, Veenhuis, Marten,, R K Szilard, Szilard, Rachel K.,, Richard A. Rachubinski, Marten Veenhuis, Veenhuis, Marten, Vladimir I. Titorenko   +15 more
core   +1 more source

Paulinella chromatophora – rethinking the transition from endosymbiont to organelle

Acta Societatis Botanicorum Poloniae, 2014
Eukaryotes co-opted photosynthetic carbon fixation from prokaryotes by engulfing a cyanobacterium and stably integrating it as a photosynthetic organelle (plastid) in a process known as primary endosymbiosis.
Eva C.M. Nowack
doaj   +1 more source

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source