Results 81 to 90 of about 746,971 (308)

MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas [PDF]

, 2006
In view of the certain anatomic site-dependent frequency of chromosomal translocations involved in extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) pathogenesis, 17 salivary gland MALT lymphoma cases were ...
Isaacson PG, Harris NL, Carbone A, Banham A, Streubel B, Ventura RA, Remstein ED, Baens M, Ye H   +8 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

RGMa Nuclear Localization in Skeletal Muscle Cells Reveals a Novel Role in Cell Viability and Proliferation

Cells
The Repulsive Guidance Molecule a (RGMa) is a multifunctional GPI-anchored protein localized in the sarcolemma and sarcoplasm of the adult skeletal muscle cell.
Cristhian David Andrade Alfaro, Julia Meireles Nogueira, Christhiam Douglas Caetano Ribeiro, Kirsty Ximena Noboa Carrasco, Ana Luísa Cremonese Lubiana, Ana Maria Alvarenga Fagundes, Natália Paloma Vieira de Souza, Victor Rodrigues Santos, Carolina Cattoni Koh, Walderez Ornelas Dutra, Erika Cristina Jorge   +10 more
doaj   +1 more source

Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. [PDF]

, 2019
PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2's activity through allosteric modulation and post-translational modifications.
Chen, Tsan-Jan, Cheng, Hsin-Hung, Hsu, Sheng-Chieh, Kung, Hsing-Jien, Liu, Jai-Shin, Liu, Ying-Yuan, Lu, Chien-Hung, Wang, Hung-Jung, Wang, Wen-Ching, Wu, Jing-Wen, Wu, Meng-Chen, Wu, Yu-Fang   +11 more
core   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells [PDF]

, 2009
When the catalytic A subunits of the castor bean toxins ricin and Ricinus communis agglutinin (denoted as RTA and RCA A, respectively) are delivered into the endoplasmic reticulum (ER) of tobacco protoplasts, they become substrates for ER ...
Richard S. Marshall, Nicholas A. Jolliffe, Aldo Ceriotti, Christopher J. Snowden, J. Michael Lord, Lorenzo Frigerio, Lynne M. Roberts, Vitale, Romisch, Meusser, Braun, Ye, Rabinovich, Jarosch, Ye, Rape, Lee, Worthington, Kothe, Feiler, Rancour, Muller, Di Cola, Di Cola, Tabe, Hellens, Frigerio, Pedrazzini, Hunter, Chaddock, Jolliffe, Roberts, Campbell, Maliga, Denecke, Klein, Martinez, Allen, Roberts, Wojcik, Dalal, Simpson, Day, Tsai, Bays, Denic, Carvalho, Swanson, Deak, Schuberth, Richly, Yoshida, Yoshida, Wiertz, Brandizzi, Roberts, Lord, Deeks, Wahlman, Wojcik, Carlson, Vashist, Vashist, Caldwell, Schmid, Kirst, Smalle, Carter, Contento, Pimpl   +69 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A functional link between the co-translational protein translocation pathway and the UPR

eLife, 2015
Upon endoplasmic reticulum (ER) stress, the transmembrane endoribonuclease Ire1α performs mRNA cleavage reactions to increase the ER folding capacity. It is unclear how the low abundant Ire1α efficiently finds and cleaves the majority of mRNAs at the ER ...
Rachel Plumb, Zai-Rong Zhang, Suhila Appathurai, Malaiyalam Mariappan   +3 more
doaj   +1 more source

Same structure, different mechanisms?

eLife, 2020
Two interpretations of similar structures for the same molecular machine illustrate the limits of inferring biochemical mechanism from protein structure.
Francis TF Tsai, Christopher P Hill
doaj   +1 more source

Protein translocation machineries: How organelles bring in matrix proteins [PDF]

FEMS Yeast Research, 2005
Eukaryotic cells contain several thousands of proteins that have to be accurately partitioned over the components of the cytoplasm (cytosol or any of the known organelles) to allow proper cell function. To this end, various specific topogenic signals have been designed as well as highly selective protein translocation machineries that ensure that each ...
Gunkel, Katja, Veenhuis, Marten, Klei, Ida J. van der   +2 more
openaire   +3 more sources