Results 81 to 90 of about 6,532,398 (348)

Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. [PDF]

, 1988
The major hepatitis B virus (HBV) core protein is a viral structural protein involved in nucleic acid binding. Its coding sequence contains an extension of 29 codons (the "precore" region) at the amino terminus of the protein which is present in a ...
Garcia, PD, Ou, JH, Rutter, WJ, Walter, P   +3 more
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

PRAT Proteins Operate in Organellar Protein Import and Export in Arabidopsis thaliana

Plants, 2021
Chloroplasts need to import preproteins and amino acids from the cytosol during their light-induced differentiation. Similarly, chloroplasts have to export organic matter including proteins and amino acids during leaf senescence.
Claudia Rossig, John Gray, Oscar Valdes, Armin Springer, Sachin Rustgi, Diter von Wettstein, Christiane Reinbothe, Joachim Rassow, Steffen Reinbothe   +8 more
doaj   +1 more source

The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells [PDF]

, 2009
When the catalytic A subunits of the castor bean toxins ricin and Ricinus communis agglutinin (denoted as RTA and RCA A, respectively) are delivered into the endoplasmic reticulum (ER) of tobacco protoplasts, they become substrates for ER ...
Aldo Ceriotti, Allen, Bays, Brandizzi, Braun, Caldwell, Campbell, Carlson, Carter, Carvalho, Chaddock, Christopher J. Snowden, Contento, Dalal, Day, Deak, Deeks, Denecke, Denic, Di Cola, Di Cola, Feiler, Frigerio, Hellens, Hunter, J. Michael Lord, Jarosch, Jolliffe, Kirst, Klein, Kothe, Lee, Lord, Lorenzo Frigerio, Lynne M. Roberts, Maliga, Martinez, Meusser, Muller, Nicholas A. Jolliffe, Pedrazzini, Pimpl, Rabinovich, Rancour, Rape, Richard S. Marshall, Richly, Roberts, Roberts, Roberts, Romisch, Schmid, Schuberth, Simpson, Smalle, Swanson, Tabe, Tsai, Vashist, Vashist, Vitale, Wahlman, Wiertz, Wojcik, Wojcik, Worthington, Ye, Ye, Yoshida, Yoshida   +69 more
core   +2 more sources

SignalP 6.0 predicts all five types of signal peptides using protein language models

Nature Biotechnology, 2022
Signal peptides (SPs) are short amino acid sequences that control protein secretion and translocation in all living organisms. SPs can be predicted from sequence data, but existing algorithms are unable to detect all known types of SPs.
Felix Teufel, J. J. Almagro Armenteros, alexander rosenberg johansen, M. H. Gíslason, Silas Irby Pihl, Konstantinos D. Tsirigos, O. Winther, S. Brunak, G. Heijne, H. Nielsen   +9 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Novel Technology for Protein-Protein Interaction-based Targeted Drug Discovery

Journal of Analytical Science and Technology, 2011
We have developed a simple but highly efficient in-cell protein-protein interaction (PPI) discovery system based on the translocation properties of protein kinase C- and its C1a domain in live cells.
Jung Me Hwang, Kyung-Bok Lee, Jong-Soon Choi, Jaerang Rho, Gun-Hwa Kim, Seung Il Kim, Soohyun Kim, Zee-Won Lee   +7 more
doaj  

A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways

eLife, 2017
The majority of multi-spanning membrane proteins are co-translationally inserted into the bilayer by the Sec pathway. An important subset of membrane proteins have globular, cofactor-containing extracytoplasmic domains requiring the dual action of the co-
Fiona J Tooke, Marion Babot, Govind Chandra, Grant Buchanan, Tracy Palmer   +4 more
doaj   +1 more source

Proteomics Identifies Substrates and a Novel Component in hSnd2-Dependent ER Protein Targeting

Cells, 2022
Importing proteins into the endoplasmic reticulum (ER) is essential for about 30% of the human proteome. It involves the targeting of precursor proteins to the ER and their insertion into or translocation across the ER membrane. Furthermore, it relies on
Andrea Tirincsi, Sarah O’Keefe, Duy Nguyen, Mark Sicking, Johanna Dudek, Friedrich Förster, Martin Jung, Drazena Hadzibeganovic, Volkhard Helms, Stephen High, Richard Zimmermann, Sven Lang   +11 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source