Results 1 to 10 of about 409,825 (329)

Proteinase 3 is involved in presepsin production through neutrophil extracellular trap phagocytosis by macrophages [PDF]

Scientific Reports
Presepsin (P-SEP), a soluble subtype of CD14, is widely recognized as a diagnostic biomarker for sepsis. However, the molecular mechanisms underlying its production remain poorly understood.
Akishige Ikegame, Akihiro Kondo, Tatsuya Morinishi, Yusuke Yamaguchi, Yui Okutani, Chinatsu Maegawa, Satoshi Tada   +6 more
doaj   +4 more sources

Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes [PDF]

Reproductive Biology and Endocrinology
Background Chronic inflammation plays a vital role in the development of gestational diabetes mellitus (GDM). Studies in mouse models show that neutrophil serine proteases (NSPs), neutrophil elastase (NE) and proteinase-3 (PR3) are important drivers of ...
Lihong Wang, Zhoujunhao Zhou, Xinming Xu, Yue Li, Rui Zhang, Zhiyan Yu, Xinmei Huang, Shufei Zang, Tiange Sun   +8 more
doaj   +4 more sources

Defensin Interactions in Relation to Monoclonal and Disease-Related Proteinase 3 Antibodies Binding at the Catalytic Site [PDF]

Antibodies, 2023
Proteinase 3 (PR3) is a neutrophil granulocyte enzyme and an autoantigen found in several forms of vasculitis. Due to the diagnostic and clinical importance of antibodies (Abs) to PR3, it is important to characterize the protein and the nature of its ...
Morten Zoega, Nicole Hartwig Trier, Rikke Guldhammer Nejrup, Anna Chailyan, Tina Friis, Peter Højrup, Gunnar Houen   +6 more
doaj   +2 more sources

A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage [PDF]

Pathophysiology, 2021
A full understanding of the molecular mechanisms implicated in the etiopathogenesis of juvenile idiopathic arthritis (JIA) is lacking. A critical role for leukocyte proteolytic activity (e.g., elastase and cathepsin G) has been proposed.
Eric K. Patterson, Nicolas Vanin Moreno, Douglas D. Fraser, Gediminas Cepinskas, Takaya Iida, Roberta A. Berard   +5 more
doaj   +2 more sources

Case Report: Proteinase 3 Antineutrophil Cytoplasmic Antibody-Associated Ulcerative Colitis Presenting as Recurrent Intestinal Pseudo-Obstruction in a Teenage Patient With in situ Proteinase 3 Immunohistochemical Staining [PDF]

Frontiers in Pediatrics, 2022
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease with the colorectum as its major target organ. Involvement of the upper gastrointestinal tract in UC is rare and presents with nonspecific endoscopic and microscopic ...
Ching-Wen Yang, Ching-Wen Yang, Yu-Chien Kao, Pei-Chun Lin, Hsi-Yuan Chien, Hsi-Yuan Chien, Sheng-Chieh Lin, Sheng-Chieh Lin, Yu-Hsien Lee, Yen-Lin Huang, Shiuh-Bin Fang, Shiuh-Bin Fang, Shiuh-Bin Fang   +12 more
doaj   +2 more sources

Orbital apex schwannoma with a high titer of proteinase 3 antineutrophil cytoplasmic antibody [PDF]

Radiology Case Reports, 2022
Here, we present a very unusual case of orbital apex schwannoma with a high titer of proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA). A 67-year-old man presented with a 3-month history of double vision.
Tatsushi Oura, MD, Taro Shimono, MD, PhD, Maciej Pas, MD, PhD, Hirotaka Takita, MD, Daisuke Horiuchi, MD, Yasuhito Mitsuyama, MD, Yukio Miki, MD, PhD   +6 more
doaj   +2 more sources

Pathogenicity of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody in Granulomatosis With Polyangiitis: Implications as Biomarker and Future Therapies [PDF]

Frontiers in Immunology, 2021
Granulomatosis with polyangiitis (GPA) is a rare but serious necrotizing auto-immune vasculitis. GPA is mostly associated with the presence of Anti-Neutrophil Cytoplasmic Antibody (ANCA) targeting proteinase 3 (PR3-ANCA), a serine protease contained in ...
Jérôme Granel, Jérôme Granel, Brice Korkmaz, Dalila Nouar, Stefanie A. I. Weiss, Dieter E. Jenne, Roxane Lemoine, Cyrille Hoarau, Cyrille Hoarau   +8 more
doaj   +2 more sources

Clinical utility of proteinase 3-antineutrophil cytoplasmic antibody at diagnosis in predicting subsequent relapse in patients with microscopic polyangiitis [PDF]

Frontiers in Medicine
BackgroundIn real clinical practice, patients classified as microscopic polyangiitis (MPA) according to the new 2022 criteria, despite proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA) positivity, are occasionally encountered.
Jang Woo Ha, Oh Chan Kwon, Yong-Beom Park, Yong-Beom Park, Sang-Won Lee, Sang-Won Lee   +5 more
doaj   +2 more sources

Circulating autoreactive proteinase 3+ B cells and tolerance checkpoints in ANCA-associated vasculitis [PDF]

JCI Insight, 2021
BACKGROUND Little is known about the autoreactive B cells in antineutrophil cytoplasmic antibody–associated (ANCA-associated) vasculitis (AAV). We aimed to investigate tolerance checkpoints of circulating antigen-specific proteinase 3–reactive (PR3+) B ...
Alvise Berti, Sophie Hillion, Amber M. Hummel, Young Min Son, Nedra Chriti, Tobias Peikert, Eva M. Carmona, Wayel H. Abdulahad, Peter Heeringa, Kristina M. Harris, E. William St. Clair, Paul Brunetta, Fernando C. Fervenza, Carol A. Langford, Cees G.M. Kallenberg, Peter A. Merkel, Paul A. Monach, Philip Seo, Robert F. Spiera, John H. Stone, Guido Grandi, Jie Sun, Jacques-Olivier Pers, Ulrich Specks, Divi Cornec, for the RAVE-ITN Research Group   +25 more
doaj   +2 more sources

Case for diagnosis. Cutaneous small vessel vasculitis (anti-proteinase 3 positive), fever, hemoptysis, and lung cavitation in an adult, [PDF]

Anais Brasileiros de Dermatologia, 2021
Small vessel vasculitis with anti-proteinase antibodies 3 is an atypical clinical presentation of tuberculosis. The authors present the case of a 47-year-old male patient, with palpable purpura and palmoplantar hemorrhagic blisters, with subsequent ...
Luana Moraes Campos, Mariana Righetto de Ré, Priscila Neri Lacerda, Hélio Amante Miot   +3 more
doaj   +3 more sources