Defensin Interactions in Relation to Monoclonal and Disease-Related Proteinase 3 Antibodies Binding at the Catalytic Site [PDF]
Antibodies, 2023 Proteinase 3 (PR3) is a neutrophil granulocyte enzyme and an autoantigen found in several forms of vasculitis. Due to the diagnostic and clinical importance of antibodies (Abs) to PR3, it is important to characterize the protein and the nature of its ...
Morten Zoega +6 more
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A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage [PDF]
Pathophysiology, 2021 A full understanding of the molecular mechanisms implicated in the etiopathogenesis of juvenile idiopathic arthritis (JIA) is lacking. A critical role for leukocyte proteolytic activity (e.g., elastase and cathepsin G) has been proposed.
Eric K. Patterson +5 more
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A specific proteinase 3 activity footprint in α1-antitrypsin deficiency
ERJ Open Research, 2019 α1-Antitrypsin (α1-AT) deficiency is a risk factor for emphysema due to tissue damage by serine proteases. Neutrophil elastase (NE) has long been considered the enzyme responsible.
Paul R. Newby +12 more
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Case Report: Proteinase 3 Antineutrophil Cytoplasmic Antibody-Associated Ulcerative Colitis Presenting as Recurrent Intestinal Pseudo-Obstruction in a Teenage Patient With in situ Proteinase 3 Immunohistochemical Staining [PDF]
Frontiers in Pediatrics, 2022 Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease with the colorectum as its major target organ. Involvement of the upper gastrointestinal tract in UC is rare and presents with nonspecific endoscopic and microscopic ...
Ching-Wen Yang +12 more
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Activation of Proteinase 3 Contributes to Nonalcoholic Fatty Liver Disease and Insulin Resistance
Molecular Medicine, 2016 Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes.
Erik J M Toonen +12 more
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Orbital apex schwannoma with a high titer of proteinase 3 antineutrophil cytoplasmic antibody [PDF]
Radiology Case Reports, 2022 Here, we present a very unusual case of orbital apex schwannoma with a high titer of proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA). A 67-year-old man presented with a 3-month history of double vision.
Tatsushi Oura, MD +6 more
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Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid? [PDF]
International Journal of Implant Dentistry, 2020 Background Inactive human cathelicidin antimicrobial peptide is present in neutrophils, and proteinase 3 activates this peptide by producing active LL-37 peptide. LL-37 acts as a defensive peptide in the oral tissues. In the present study, the aim was to
Oya Turkoglu +2 more
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Pathogenicity of Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody in Granulomatosis With Polyangiitis: Implications as Biomarker and Future Therapies [PDF]
Frontiers in Immunology, 2021 Granulomatosis with polyangiitis (GPA) is a rare but serious necrotizing auto-immune vasculitis. GPA is mostly associated with the presence of Anti-Neutrophil Cytoplasmic Antibody (ANCA) targeting proteinase 3 (PR3-ANCA), a serine protease contained in ...
Jérôme Granel +8 more
doaj +2 more sources
Haematologica, 2011 Background A deficiency of specific glycosylphosphatidyl inositol-anchored proteins in paroxysmal nocturnal hemoglobinuria may be responsible for most of the clinical features of this disease, but some functional consequences may be indirect. For example,
Anna M. Jankowska +7 more
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Circulating autoreactive proteinase 3+ B cells and tolerance checkpoints in ANCA-associated vasculitis [PDF]
JCI Insight, 2021 BACKGROUND Little is known about the autoreactive B cells in antineutrophil cytoplasmic antibody–associated (ANCA-associated) vasculitis (AAV). We aimed to investigate tolerance checkpoints of circulating antigen-specific proteinase 3–reactive (PR3+) B ...
Alvise Berti +25 more
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