Results 11 to 20 of about 409,825 (329)

Activation of Proteinase 3 Contributes to Nonalcoholic Fatty Liver Disease and Insulin Resistance [PDF]

Molecular Medicine, 2016
Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes.
Erik J M Toonen, Andreea-Manuela Mirea, Cees J Tack, Rinke Stienstra, Dov B Ballak, Janna A van Diepen, Anneke Hijmans, Triantafyllos Chavakis, Wim H Dokter, Christine T N Pham, Mihai G Netea, Charles A Dinarello, Leo A B Joosten   +12 more
doaj   +4 more sources

Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow [PDF]

Stem Cell Reports, 2018
Summary: Hematopoietic stem and progenitor cells (HSPCs) undergo self-renewal and differentiation to guarantee a constant supply of short-lived blood cells.
Kutay Karatepe, Haiyan Zhu, Xiaoyu Zhang, Rongxia Guo, Hiroto Kambara, Fabien Loison, Peng Liu, Hongbo Yu, Qian Ren, Xiao Luo, John Manis, Tao Cheng, Fengxia Ma, Yuanfu Xu, Hongbo R. Luo   +14 more
doaj   +2 more sources

High serum proteinase-3 levels predict poor progression-free survival and lower efficacy of bevacizumab in metastatic colorectal cancer [PDF]

BMC Cancer
Background To improve the prognosis of patients with metastatic colorectal cancer (mCRC), investigating predictive biomarkers of their prognosis and chemotherapeutic responsiveness is necessary.
Kei Furuya, Masao Nakajima, Ryouichi Tsunedomi, Yuki Nakagami, Ming Xu, Hiroto Matsui, Yukio Tokumitsu, Yoshitaro Shindo, Yusaku Watanabe, Shinobu Tomochika, Noriko Maeda, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Shoichi Hazama, Tatsuya Ioka, Yoshinobu Hoshii, Tomio Ueno, Hiroaki Nagano   +18 more
doaj   +2 more sources

Immunological Interaction of HLA-DPB1 and Proteinase 3 in ANCA Vasculitis is Associated with Clinical Disease Activity.

J Am Soc Nephrol, 2022
Chen DP, McInnis EA, Wu EY, Stember KG, Hogan SL, Hu Y, Henderson CD, Blazek LN, Mallal S, Karosiene E, Peters B, Sidney J, James EA, Kwok WW, Jennette JC, Ciavatta DJ, Falk RJ, Free ME.   +17 more
europepmc   +3 more sources

A Diagnostic Dilemma: Proteinase-3 (PR3)-Positive Anti-neutrophil Cytoplasmic Autoantibodies in Eosinophilic Granulomatosis With Polyangiitis. [PDF]

Cureus
Goldman S, Wilson B, Awan K, White T, Williams M.   +4 more
europepmc   +3 more sources

An Unusual Presentation of Propylthiouracil-Induced Immunoglobulin A Vasculitis With Positive Anti-proteinase-3 and Anti-myeloperoxidase Antibodies. [PDF]

Cureus
Custer MK, Kidd T, Ducker K, Lall R.
europepmc   +3 more sources

Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab. [PDF]

Intern Med, 2021
Yoshida S, Hanai S, Nakagomi D, Kobayashi K, Takahashi K, Furuya F.   +5 more
europepmc   +3 more sources

Camostat Does Not Inhibit the Proteolytic Activity of Neutrophil Serine Proteases

Pharmaceuticals, 2022
Coronavirus disease 2019 (COVID-19) can lead to multi-organ failure influenced by comorbidities and age. Binding of the severe acute respiratory syndrome coronavirus 2 spike protein (SARS-CoV-2 S protein) to angiotensin-converting enzyme 2 (ACE2), along ...
Akmaral Assylbekova, Anuar Zhanapiya, Renata Grzywa, Marcin Sienczyk, Christian Schönbach, Timo Burster   +5 more
doaj   +1 more source

Neutrophils in ANCA-associated vasculitis: Mechanisms and implications for management

Frontiers in Pharmacology, 2022
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of systemic autoimmune diseases, which is typified by inflammatory necrosis predominantly affecting the small vessels and often accompanied by positive ANCA.
Shangqing Ge, Xingyu Zhu, Qinyao Xu, Junyan Wang, Cheng An, Ying Hu, Fan Yang, Xinyi Wang, Yipin Yang, Shuwen Chen, Ruimin Jin, Haiyan Li, Xinchen Peng, Yue Liu, Junnan Xu, Minhui Zhu, Zongwen Shuai   +16 more
doaj   +1 more source

Upper respiratory tract manifestations in patients with ANCA-associated vasculitides and their association with the presence and type of ANCA

Научно-практическая ревматология, 2021
Aim of the work – to compare the frequency of upper respiratory tract (URT) involvement in patients with ANCAassociated vasculitides (AAV), to reveal its main clinical and radiological patterns and to estimate their association with the serological ...
I. G. Smirnova, N. M. Bulanov, P. I. Novikov, I. A. Osipova, S. V. Moiseev   +4 more
doaj   +1 more source