Proteinase 3 associated with Wegener's granulomatosis [PDF]
Cell Biology International, 2021 Wegener's granulomatosis (WG) is a form of systemic vasculitis characterized by granulomatous inflammation of the upper and lower airways, vasculitis, and necrotizing glomerulonephritis.
W. H. Goldmann
semanticscholar +4 more sources
Respiratory Research, 2018 Chronic Obstructive Pulmonary Disease (COPD) is a common, multifactorial lung disease which results in significant impairment of patients’ health and a large impact on society and health care burden.
Helena Crisford +2 more
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Characterization of the CD177 interaction with the ANCA antigen proteinase 3 [PDF]
Scientific Reports, 2017 Proteinase 3 is a serine protease found in neutrophil granules and on the extracellular neutrophil membrane (mPR3). mPR3 is a major antigen for anti-neutrophil cytoplasmic antibodies (PR3-ANCAs), autoantibodies causing fatal autoimmune diseases.
Uwe Jerke +3 more
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Case for diagnosis. Cutaneous small vessel vasculitis (anti-proteinase 3 positive), fever, hemoptysis, and lung cavitation in an adult, [PDF]
Anais Brasileiros de Dermatologia, 2021 Small vessel vasculitis with anti-proteinase antibodies 3 is an atypical clinical presentation of tuberculosis. The authors present the case of a 47-year-old male patient, with palpable purpura and palmoplantar hemorrhagic blisters, with subsequent ...
Luana Moraes Campos +3 more
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Role of saliva proteinase 3 in dental caries [PDF]
International Journal of Oral Science, 2015 Salivary analysis can be used to assess the severity of caries. Of the known salivary proteins, a paucity of information exists concerning the role of proteinase 3 (PR3), a serine protease of the chymotrypsin family, in dental caries. Whole, unstimulated
Teng-yu Yang +14 more
semanticscholar +4 more sources
High serum proteinase-3 levels predict poor progression-free survival and lower efficacy of bevacizumab in metastatic colorectal cancer [PDF]
BMC CancerBackground To improve the prognosis of patients with metastatic colorectal cancer (mCRC), investigating predictive biomarkers of their prognosis and chemotherapeutic responsiveness is necessary.
Kei Furuya +18 more
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Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes [PDF]
Reproductive Biology and EndocrinologyBackground Chronic inflammation plays a vital role in the development of gestational diabetes mellitus (GDM). Studies in mouse models show that neutrophil serine proteases (NSPs), neutrophil elastase (NE) and proteinase-3 (PR3) are important drivers of ...
Lihong Wang +8 more
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Proteinase 3 gene polymorphisms and Wegener's granulomatosis [PDF]
Kidney International, 2000 Wegener's granulomatosis (WG) is a rare systemic autoimmune disease characterized by small-vessel vasculitis leading to organ damage and the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). ANCAs were shown to be involved in the pathogenesis of the disease by increasing adhesion of polymorphonuclear cells (PMNs) to endothelial cells and ...
Martin Genčík +3 more
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Proteinase 3: the odd one out that became an autoantigen [PDF]
Journal of Leukocyte Biology, 2017 AbstractNeutrophils are critical in the defense against bacterial and fungal pathogens, and they also modulate the inflammatory process. The areas where neutrophils are studied have expanded from the restricted field of antibacterial defense to the modulation of inflammation and finally, to fine-tuning immune responses. As a result, recent studies have
Katherine R. Martin, V. Witko-Sarsat
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Neutrophils in ANCA-associated vasculitis: Mechanisms and implications for management
Frontiers in Pharmacology, 2022 Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of systemic autoimmune diseases, which is typified by inflammatory necrosis predominantly affecting the small vessels and often accompanied by positive ANCA.
Shangqing Ge +16 more
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