Results 31 to 40 of about 16,522,946 (324)

Type of ANCA May Be Indispensable in Distinguishing Subphenotypes of Different Clinical Entities in ANCA-Associated Vasculitis

Life, 2022
The traditional nomenclature system for classifying antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) based on clinical phenotype describes granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA)
Afroditi Maria Konstantouli, Georgios Lioulios, Stamatia Stai, Eleni Moysidou, Asimina Fylaktou, Aikaterini Papagianni, Maria Stangou   +6 more
doaj   +1 more source

Increased Membrane Expression of Proteinase 3 during Neutrophil Adhesion in the Presence of Anti–Proteinase 3 Antibodies [PDF]

Journal of the American Society of Nephrology, 2007
We investigated membrane proteinase 3 (mPR3) expression during TNF-alpha-induced adhesion of neutrophils in the presence of anti-PR3 antibodies, a situation occurring during anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitis. Three increasing levels of mPR3 expression were observed on the mPR3(+) neutrophil subset after stepwise ...
Luc Mouthon, Philippe Lesavre, Fadi Fakhouri, Soumeya Brachemi, Loïc Guillevin, Agnès Mambole, Lise Halbwachs-Mecarelli   +6 more
openaire   +3 more sources

Microscopic polyangiitis: Modern concepts and treatment options

Научно-практическая ревматология, 2021
The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation ...
I. T. Murkamilov, K. A. Aitbaev, V. V. Fomin, I. O. Kudaibergenova, F. A. Yusupov, Zh. A. Murkamilova, T. V. Beketova   +6 more
doaj   +1 more source

Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties

Journal of Biological Chemistry, 1991
Proteinase 3 (PR-3) is a human polymorphonuclear leukocyte (PMNL) serine proteinase that degrades elastin in vitro and causes emphysema when administered by tracheal insufflation to hamsters (Kao, R. C., Wehner, N. G., Skubitz, K. M., Gray, B. H., and Hoidal, J. R. (1988) J. Clin. Invest. 82, 1963-1973).
John R. Hoidal, Nancy G. Wehner, Bruce C. Marshall, Beulah H. Gray, Narayanam V. Rao, William R. Gray   +5 more
openaire   +3 more sources

Membrane Expression of Proteinase 3 Is Genetically Determined [PDF]

Journal of the American Society of Nephrology, 2003
Isolated human neutrophils exhibit a bimodal membrane proteinase 3 (PR3) expression. PR3 is the main target antigen in Wegener granulomatosis (WG). Cells with low expression can be easily distinguished from cell subsets with high expression. In a recent study, a large neutrophil subset expressing membrane PR3 (mPR3+) was a risk factor for systemic ANCA-
Adrian Schreiber, Andreas Busjahn, Friedrich C. Luft, Ralph Kettritz   +3 more
openalex   +4 more sources

Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone.

Cancer Research, 2017
Human prostate cancer often metastasizes to bone, but the biological basis for such site-specific tropism remains largely unresolved. Recent work led us to hypothesize that this tropism may reflect pathogenic interactions between RAGE, a cell surface ...
M. Kolonin, Anna Sergeeva, Daniela I. Staquicini, Tracey L. Smith, C. Tarleton, J. Molldrem, R. Sidman, S. Marchiò, R. Pasqualini, W. Arap   +9 more
semanticscholar   +1 more source

Comparative aspects of murine proteinase 3

Rheumatology International, 2010
The neutrophilic granule protein proteinase 3 (PR3) is the preferred target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) found in the serum of patients with Wegener's granulomatosis, a systemic small-vessel vasculitis. Due to the lack of data concerning the murine homologue of human PR3, we assessed the neutrophil marker polypeptide PR3 in ...
Relle, Manfred, Thomaidis, Thomas, Galle, Peter R., Schwarting, Andreas   +3 more
openaire   +4 more sources

Substrate and inhibitor studies on proteinase 3

FEBS Letters, 1992
Various amino acid and peptide thioesters were tested as substrates for human proteinase 3 and the best substrate is Boc‐Ala‐Ala‐Nva‐SBzl with a k cal/K m value of 1.0 × 106nMit‐1sit‐1 Boc‐Ala‐Ala‐AA‐SBzl (AA = Val, Ala, or Met) are also good substrates with k cal/K m values of (1‐4) × 105 M−1 s−1.
Chih-Min Kam, Albert E. G. Kr. von dem Borne, Roel Goldschmeding, Koert M. Dolman, James C. Powers, John E. Kerrigan   +5 more
openaire   +3 more sources

Proteinase 3-antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis complicated by infectious endocarditis: a case report

Journal of Medical Case Reports, 2019
Background Proteinase 3-antineutrophil cytoplasmic antibody has been reported to be positive in 5–10% of cases of renal injury complicated by infective endocarditis; however, histological findings have rarely been reported for these cases.
Katsunori Yanai, Yoshio Kaku, Keiji Hirai, Shohei Kaneko, Saori Minato, Yuko Mutsuyoshi, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Masahiro Hiruta, Susumu Ookawara, Yoshihiko Ueda, Yoshiyuki Morishita   +15 more
doaj   +1 more source

Galectin-1 Facilitates Macrophage Reprogramming and Resolution of Inflammation Through IFN-β

Frontiers in Pharmacology, 2020
During the resolution of acute inflammation, macrophages undergo reprogramming from pro-inflammatory, to anti-inflammatory/reparative, and eventually to pro-resolving macrophages. Galectin-1 (Gal-1) is a bona fide pro-resolving lectin while interferon β (
Hiba Yaseen, Sergei Butenko, Irina Polishuk-Zotkin, Sagie Schif-Zuck, Juan Manuel Pérez-Sáez, Gabriel Adrian Rabinovich, Gabriel Adrian Rabinovich, Amiram Ariel   +7 more
doaj   +1 more source