Results 31 to 40 of about 409,825 (329)

Antineutrophil cytoplasmic antibodies

Reumatismo, 2011
Antineutrophil cytoplasmic antibodies (ANCA) are predominantly IgG autoantibodies directed against constituents of primary granules of neutrophils and monocytes’ lysosomes.
G.D. Sebastiani
doaj   +1 more source

Variation of Proteolytic Cleavage Sites towards the N-Terminal End of the S2 Subunit of the Novel SARS-CoV-2 Omicron Sublineage BA.2.12.1

Molecules, 2022
The prevalence of novel SARS-CoV-2 variants is also accompanied by an increased turnover rate and additional cleavage sites at the positions necessary for priming the Spike (S) protein.
Nadine Anna Schilling, Hubert Kalbacher, Timo Burster   +2 more
doaj   +1 more source

Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells

Frontiers in Immunology, 2018
Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs).
Pascale Tacnet-Delorme, Julie Gabillet, Julie Gabillet, Julie Gabillet, Simon Chatfield, Simon Chatfield, Simon Chatfield, Simon Chatfield, Nathalie Thieblemont, Nathalie Thieblemont, Nathalie Thieblemont, Nathalie Thieblemont, Philippe Frachet, Véronique Witko-Sarsat, Véronique Witko-Sarsat, Véronique Witko-Sarsat, Véronique Witko-Sarsat   +16 more
doaj   +1 more source

Galectin-1 Facilitates Macrophage Reprogramming and Resolution of Inflammation Through IFN-β

Frontiers in Pharmacology, 2020
During the resolution of acute inflammation, macrophages undergo reprogramming from pro-inflammatory, to anti-inflammatory/reparative, and eventually to pro-resolving macrophages. Galectin-1 (Gal-1) is a bona fide pro-resolving lectin while interferon β (
Hiba Yaseen, Sergei Butenko, Irina Polishuk-Zotkin, Sagie Schif-Zuck, Juan Manuel Pérez-Sáez, Gabriel Adrian Rabinovich, Gabriel Adrian Rabinovich, Amiram Ariel   +7 more
doaj   +1 more source

ANCA Testing in Clinical Practice: From Implementation to Quality Control and Harmonization

Frontiers in Immunology, 2021
Analyses for the presence of anti-neutrophil cytoplasmic antibodies (ANCA) are important in the diagnostic work-up of patients with small vessel vasculitis.
Jan Damoiseaux
doaj   +1 more source

A specific proteinase 3 activity footprint in α1-antitrypsin deficiency

ERJ Open Research, 2019
α1-Antitrypsin (α1-AT) deficiency is a risk factor for emphysema due to tissue damage by serine proteases. Neutrophil elastase (NE) has long been considered the enzyme responsible.
Paul R. Newby, Diana Crossley, Helena Crisford, James A. Stockley, Richard A. Mumford, Richard I. Carter, Charlotte E. Bolton, Nicholas S. Hopkinson, Ravi Mahadeva, Michael C. Steiner, Tom M.A. Wilkinson, Elizabeth Sapey, Robert A. Stockley   +12 more
doaj   +1 more source

Proteinase 3 gene polymorphisms and Wegener's granulomatosis [PDF]

Kidney International, 2000
Wegener's granulomatosis (WG) is a rare systemic autoimmune disease characterized by small-vessel vasculitis leading to organ damage and the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). ANCAs were shown to be involved in the pathogenesis of the disease by increasing adhesion of polymorphonuclear cells (PMNs) to endothelial cells and ...
Gencik, Martin, Meller, Stephan, Borgmann, Stefan, Fricke, Harald   +3 more
openaire   +2 more sources

Characterization of serine proteinase expression in agaricus bisporus and coprinopsis cinerea by using green fluorescent protein and the A. bisporus SPR1 Promoter [PDF]

, 2008
The Agaricus bisporus serine proteinase 1 (SPR1) appears to be significant in both mycelial nutrition and senescence of the fruiting body.
Andy M. Bailey, Andy M. Bailey, Claudine Porta, Claudine Porta, Cunjin Zhang, Cunjin Zhang, Gary D, Gary D. Foster, Kerry S, Kerry S. Burton, Mary N. Heneghan, Mary N. Heneghan, Michael P. Challen, Michael P. Challen   +13 more
core   +4 more sources

Biogenesis of Glyoxysomes [PDF]

, 1980
Biosynthesis of isocitrate lyase, a tetrameric enzyme of the glyoxysomal matrix, was studied in Neurospora crassa, in which the formation of glyoxysomes was induced by a substitution of sucrose medium by acetate medium. * 1.
Neupert, Walter, Zimmermann, Richard
core   +1 more source

Degradation of human kininogens with the release of kinin peptides by extracellular proteinases of Candida spp. [PDF]

, 2010
The secretion of proteolytic enzymes by pathogenic microorganisms is one of the most successful strategies used by pathogens to colonize and infect the host organism.
Ben Nasr A., Ben Nasr A., Bergmann S., Boskey E.R., Colman R.W., De Bernardis F., Frick I.M., Imamura T., Kaminishi H., Karkowska-Kuleta J., Koelsch G., Maeda H., Maruo K., Matsudaira P., Molla A., Tapper H., White T.C.   +16 more
core   +1 more source