LOXL2 in anabolic response to chondrodysplasia mice progressive TMJ and knee osteoarthritis [PDF]
, 2019 Osteoarthritis (OA) is a degenerative joint disease that affects an estimated 9.6 % of men and 18 % of women over 60 years of age. However, there is no chondroprotective agent that is approved for clinical application.
Alsaqer, Saqer
core
4D Bioprinted Self‐Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea
Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.A bilayer self‐folding scaffold, triggerable by humidity, is fabricated via 4D bioprinting for trachea engineering. An analytical model is derived to predict its radius of curvature, enabling its scalability. Cartilage progenitor cells seeded on the scaffold perceive scaffold final curvature and react to it, by enhancing the upregulation of pro ...
Irene Chiesa +4 more
wiley +1 more source
Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis [PDF]
European Cells & Materials, 2007 Magnetic resonance imaging of articular cartilage has recently been recognized as a tool for the characterization of cartilage morphology, biochemistry and function.
G Blumenkrantz, S Majumdar
doaj
Biology and Biomechanics of the Heart Valve Extracellular Matrix
Journal of Cardiovascular Development and Disease, 2020 Heart valves are dynamic structures that, in the average human, open and close over 100,000 times per day, and 3 × 109 times per lifetime to maintain unidirectional blood flow.
Karthik M. Kodigepalli +7 more
doaj +1 more source
Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature. [PDF]
, 2018 Regulation of autophagy by proteolytically cleaved fragments of heparan sulfate proteoglycans is a novel and current research focus in tumor biology. Endorepellin is the C-terminal angiostatic fragment of the heparan sulfate proteoglycan perlecan and ...
Andreuzzi, Eva +5 more
core +1 more source
Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. [PDF]
, 2013 NG2 (nerve/glial antigen2)-expressing cells represent the largest population of postnatal progenitors in the central nervous system and have been classified as oligodendroglial progenitor cells, but the fate and function of these cells remain ...
Chung, S-H +4 more
core +2 more sources
Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, EarlyView.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
Proteoglycans and Osteolysis [PDF]
, 2011 Osteolysis is a complex mechanism resulting from an exacerbated activity of osteoclasts associated or not with a dysregulation of osteoblast metabolism leading to bone loss. This bone defect is not compensated by bone apposition or by apposition of bone matrix with poor mechanical quality.
Baud'Huin, Marc +6 more
openaire +4 more sources
Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate. [PDF]
, 2019 Collagen remodeling occurs in many prostate pathologies; however, the underlying structural architecture in both normal and diseased prostatic tissues is largely unexplored.
Bushman, Wade A. +5 more
core +1 more source
Advanced Science, EarlyView.FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu +12 more
wiley +1 more source