Results 211 to 220 of about 76,619 (310)

Integrated nanoindentation-Raman spectroscopy reveals microscale biomechanical and molecular biomarkers of early intervertebral disc degeneration in a rat model. [PDF]

Mater Today Bio
Azril, Huang KY, Liu WL, Chen WY, Gean CY, Rouhani M, Hobley J, Metla SBS, Jeng YR.   +8 more
europepmc   +1 more source

Testican‐1‐MMP axis in tumour extracellular matrix (ECM) remodelling: interaction dynamics analysis and an in silico perspective

The Journal of Pathology, EarlyView.
Abstract The extracellular matrix (ECM) plays a pivotal role in facilitating tumour development, invasiveness, metastasis, and immunoevasive processes through dynamic ECM remodelling processes. Testican‐1 (SPOCK1), an excretory matricellular proteoglycan, is suggested to exert a role in the facilitation of ECM remodelling processes through interacting ...
Sepideh Youssefi, Kiarash Saleki, Prerna Kadam, Amirreza Mazloomi, Abhik Mukherjee, Lodewijk V Dekker, Abdolrahman S Nateri   +6 more
wiley   +1 more source

Depth-Wise Changes in Tibial and Femoral Human Knee Joint Cartilage at Different Severities of Osteoarthritis. [PDF]

J Orthop Res
Honkapää K, Eskelinen ASA, Mikkonen S, Ebrahimi M, Finnilä MAJ, Saarakkala S, Korhonen RK, Englund M, Tanska P.   +8 more
europepmc   +1 more source

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis

The Journal of Pathology, EarlyView.
Abstract Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities.
Suneeti R Madhavan, Piper Moore, Rohan Varshney, Miles Montegut, Qiannan Ma, Kayla Klatt, Reshmi Parameswaran, Elif G Ertugral, Chandrasekhar R Kothapalli, Michael C Rudolph, Radhika P Atit   +10 more
wiley   +1 more source

Structure and Function of Ocular Proteoglycans: Essential Proteins for Vision. [PDF]

Int J Mol Sci
Melrose J.
europepmc   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

MRI-Histopathology Correlation of Cartilage and Bone in Early Knee Osteoarthritis. [PDF]

J Orthop Case Rep
Jamaria S, Pasumarthy A, Bera AP, Gupta S, Biswas G, Alsaifi MS.   +5 more
europepmc   +1 more source

Current Trends and Future Prospects of Integrating Electrospinning With 3D Printing Techniques for Mimicking Bone Extracellular Matrix Scaffolds

Journal of Polymer Science, Volume 63, Issue 6, Page 1481-1504, 15 March 2025.
ABSTRACT This article presents a review of the recent findings on the combination of electrospun nanofibers and three‐dimensional (3D)‐printed structures for extracellular matrix (ECM) scaffolds for bone tissue engineering. We explore the synergy between electrospinning (ES), which produces highly porous, fibrous structures from materials like collagen
Kardo Khalid Abdullah, Kolos Molnár
wiley   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

KNG-1, HSPG and Robo4 reflect hypertension-driven subclinical renal alterations and provide incremental diagnostic value in type 2 diabetic nephropathy. [PDF]

Sci Rep
Hamed HI, Amin AI, Ahmed HR, Akabawy AMA.   +3 more
europepmc   +1 more source