Results 231 to 240 of about 84,285 (265)

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

High cholesterol absorption efficiency enhances proatherogenic properties of low-density lipoprotein particles. [PDF]

J Intern Med
Öörni K, Äikäs L, Ruuth M, Tigistu-Sahle F, Käkelä R, Wester I, Gylling H, Simonen P.   +7 more
europepmc   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Increased transvascular retention of atherogenic lipoproteins in type 2 diabetes relates to their enhanced proteoglycan binding. [PDF]

JCI Insight
Björklund P, Härdfeldt J, Äikäs L, Straniero S, Holopainen M, Öörni K, Rudling M, Angelin B.   +7 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Aortic Stenosis Hyalectan Remodeling Revealed by Proteomics and Glycoproteomics. [PDF]

Arterioscler Thromb Vasc Biol
Yin S, Mayr U, Barallobre-Barreiro J, Duregotti E, Barton AK, Bing R, Markose D, Yin X, Sarathchandra P, Singh B, Lin WY, Fava M, Schmidt LE, Baig F, Shah AM, Theofilatos K, Latif N, Hengstenberg C, Radovits T, Merkely B, Henderson NC, Dweck MR, Mayr M.   +22 more
europepmc   +1 more source

Arthroscopically and manually minced cartilage demonstrates lower cell viability and lower proteoglycan deposition compared to isolated chondrons and chondrocytes. [PDF]

Osteoarthr Cartil Open
Scheepmaker D, Nagelli CV, Lydon KL, Vonk LA, Krych AJ, Custers RJ, Saris DB, Korpershoek JV.   +7 more
europepmc   +1 more source