Results 1 to 10 of about 189,785 (400)

Glycosaminoglycans and Proteoglycans [PDF]

Pharmaceuticals, 2018
In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan,
Vitor H. Pomin, Barbara Mulloy
doaj   +5 more sources

Proteoglycans as Mediators of Cancer Tissue Mechanics

Frontiers in Cell and Developmental Biology, 2020
Proteoglycans are a diverse group of molecules which are characterized by a central protein backbone that is decorated with a variety of linear sulfated glycosaminoglycan side chains.
Alexander Buffone, Valerie M Weaver, Steffen Massberg   +2 more
exaly   +4 more sources

Proteoglycans and neuronal migration in the cerebral cortex during development and disease [PDF]

Frontiers in Neuroscience, 2015
Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many proteins including growth factors, chemokines, axon guidance molecules,
Nobuaki eMaeda
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Atherosclerosis: from lipid-lowering and anti-inflammatory therapies to targeting arterial retention of ApoB-containing lipoproteins [PDF]

Frontiers in Immunology
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, fibrous elements, and cellular debris in the blood vessels. The response-to-retention hypothesis, the leading theory on the pathogenesis of this cardiovascular
Gala Araujo, Leidy Marian Valencia, Agata Martin-Ozimek, Yosdel Soto, Yosdel Soto, Spencer D. Proctor   +5 more
doaj   +2 more sources

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

Journal of Cellular and Molecular Medicine, 2011
•  Introduction •  Perlecan: a pro‐angiogenic proteoglycan •  Endorepellin, a C‐terminal fragment of perlecan with anti‐angiogenic activity •  Syndecans in cancer biology •  Glypicans and the control of cancer growth •  Role of heparanase and ...
Renato V Iozzo, Ralph D Sanderson, Derek M Yellon   +2 more
exaly   +2 more sources

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans

Nature Neuroscience, 2012
In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting following injury.
Katherine T Baldwin, Andrew Wood, Cédric G Geoffroy   +2 more
exaly   +2 more sources

Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis

Brain, 2018
Manoj K Mishra, Serge Rivest, Chang-chun Ling   +2 more
exaly   +2 more sources

The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury

Frontiers in Medicine, 2023
BackgroundCalcineurin inhibitors (CNIs) are associated with nephrotoxicity, endothelial cell dysfunction, and thrombotic microangiopathy (TMA). Evolving evidence suggests an important role for complement dysregulation in the pathogenesis of CNI-induced ...
Chia Wei Teoh, Chia Wei Teoh, Chia Wei Teoh, Chia Wei Teoh, Magdalena Riedl Khursigara, Magdalena Riedl Khursigara, Magdalena Riedl Khursigara, Carolina G. Ortiz-Sandoval, Jee Woo Park, Jun Li, Arlette Bohorquez-Hernandez, Valentina Bruno, Valentina Bruno, Valentina Bruno, Emily E. Bowen, Spencer A. Freeman, Spencer A. Freeman, Lisa A. Robinson, Lisa A. Robinson, Lisa A. Robinson, Lisa A. Robinson, Christoph Licht, Christoph Licht, Christoph Licht, Christoph Licht, Christoph Licht   +25 more
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Roles of Chondroitin Sulfate Proteoglycans as Regulators of Skeletal Development

Frontiers in Cell and Developmental Biology, 2022
The extracellular matrix (ECM) is critically important for most cellular processes including differentiation, morphogenesis, growth, survival and regeneration.
Nancy B. Schwartz, Nancy B. Schwartz, Miriam S. Domowicz   +2 more
doaj   +1 more source

The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs

JOR Spine, 2022
Introduction Diabetes has long been implicated as a major risk factor for intervertebral disc (IVD) degeneration, interfering with molecular signaling and matrix biochemistry, which ultimately aggravates the progression of the disease.
Marianne Lintz, Remy E. Walk, Simon Y. Tang, Lawrence J. Bonassar   +3 more
doaj   +1 more source