Results 1 to 10 of about 132,430 (262)

Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury [PDF]

, 2017
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs.
A Mackay-Sim, A Mackay-Sim, A Ramón-Cueto, AW Barritt, BJ Dlouhy, C Deng, C Kachramanoglou, CH Tator, CM Galtrey, CM Galtrey, CM Galtrey, CP Hofstetter, D Carwardine, D Choi, D Choi, D Ito, D Reginensi, D Wang, Darren Carwardine, E Neafsey, EJ Bradbury, EJ Bradbury, EJ Bradbury, Elizabeth M. Muir, EM Muir, ER Burnside, F Feron, F Roloff, G Garcia-Alias, G Garcia-Alias, H Lee, HH Nash, J Silver, JA Ekberg, Jacob Neeves, James Uney, JC Kwok, JL Kueh, JM Massey, Jonathan Prager, K Bartus, K Oprych, KC Roet, L Moon, L Naldini, LC Weaver, Liang-Fong Wong, LL Jones, M Gossen, M Ruitenberg, MB Bunge, MH Grider, MI Chuah, MI Romero, Michael G Fehlings, ML Starkey, N Granger, N Jeffery, NA Silva, ND James, Nicolas Granger, NJ Tester, NJ Tester, P Brundin, P Tabakow, P Tabakow, PH Laverty, R Watzlawick, R-R Zhao, RJ Franklin, RR Khankan, S Karimi-Abdolrezaee, S Li, S Thuret, SA Moore, SC Jefferson, SJ Davies, T Hagg, T Imaizumi, T Kawahara, U Baron, WJ Alilain, WTJ Morgan, Y Li, Y Li, Y Wang   +85 more
core   +24 more sources

Glycosaminoglycans and Proteoglycans [PDF]

Pharmaceuticals, 2018
In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan, serglycin, cell-surface proteoglycans, like syndecans and glypicans, and the extracellular matrix ...
Vitor Pomin, Barbara Mulloy
openaire   +4 more sources

Proteoglycans and Osteolysis [PDF]

, 2011
Osteolysis is a complex mechanism resulting from an exacerbated activity of osteoclasts associated or not with a dysregulation of osteoblast metabolism leading to bone loss. This bone defect is not compensated by bone apposition or by apposition of bone matrix with poor mechanical quality.
Marc Baud'huin, Dominique Heymann, Dominique Heymann, Dominique Heymann, Céline Charrier, Céline Charrier, Frédéric Lézot, Frédéric Lézot, Régis Brion, Régis Brion, Marc Padrines, Marc Padrines, Gwenola Bougras, Gwenola Bougras   +13 more
openaire   +6 more sources

Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. [PDF]

, 2006
Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic ...
Bishop, Joseph R, Esko, Jeffrey D, Oegema, Karen, Olson, Sara K, Yates, John R   +4 more
core   +2 more sources

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. [PDF]

, 2017
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and ...
Cohen IR, Douglass S, Kalas W, Mathiak M, Onita T, Zhu YH   +5 more
core   +2 more sources

Evidence for the role of proteoglycans in cation-mediated gene transfer [PDF]

, 1996
We report evidence that gene complexes, consisting of polycations and plasmid DNA enter cells via binding to membrane-associated proteoglycans. Treatment of HeLa cells with sodium chlorate, a potent inhibitor of proteoglycan sulfation, reduced luciferase
Baldeschwieler, John D., Mislick, Kimberly A.   +1 more
core   +1 more source

Cartilage proteoglycans [PDF]

Seminars in Cell & Developmental Biology, 2001
The predominant proteoglycan present in cartilage is the large chondroitin sulfate proteoglycan 'aggrecan'. Following its secretion, aggrecan self-assembles into a supramolecular structure with as many as 50 monomers bound to a filament of hyaluronan.
Warren Knudson, Cheryl B. Knudson
openaire   +3 more sources

Gene expression and matrix turnover in overused and damaged tendons [PDF]

, 2005
Chronic, painful conditions affecting tendons, frequently known as tendinopathy, are very common types of sporting injury. The tendon extracellular matrix is substantially altered in tendinopathy, and these changes are thought to precede and underlie the
Abbaszade I, Akeson WH, Alfredson H, Amiel D, Archambault J, Astrom M, Bank RA, Banyard J, Benjamin M., Berenson MC, Boot-Handford RP, Brown PD., Cal S, Caterson B, Cawston TE, Cawston TE., Clark IM, Colige A, Colige A, Collins-Racie LA, Corps AN, Corps AN, Curwin SL, Dalton S, Dickinson SC, Eriksen HA, Everts V, Fernandes RJ, Fitzgerald J, Flannery CR, G. P. Riley, Gao G, Gelberman RH, Gillard GC, Gotoh M, Hannafin JA., Hardingham TE, Hashimoto T, Heinemeier K, Ireland D, Jarvinen M, Jozsa L, Jozsa L, Kannus P, Kannus P., Kannus P., Kashiwagi M, Kashiwagi M, Kaushal GP, Kjaer M, Koch M, Koch M, Koshy PJ, Koskinen SO, Kuno K, Langberg H, Langberg H, Langberg H, Leadbetter WB., Lehto M, McCawley LJ, McNeilly CM, Murphy G, Myllyharju J, Nagase H., Pace JM, Patterson-Kane JC, Pierfitte C, Rees SG, Riley G., Riley GP, Riley GP, Riley GP, Riley GP, Riley GP, Riley GP., Samiric T, Samiric T, Sandy JD, Sandy JD, Sandy JD, Sato K, Smith RK, Smith RK, Somerville RP, Tipton CM, Tortorella MD, Tortorella MD, Tsuzaki M, Vankemmelbeke MN, Vogel KG, Waggett AD, Wang P, Woo SLY, Woo SLY, Woo SLY, Yasuda K, Yoshihara Y   +97 more
core   +1 more source

Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro [PDF]

, 2005
Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of collagen fibrils in vitro.
Crombie, Duncan E, Holmdahl, Rikard, McNaughton, Don, Nandakumar, Kutty Selva, Rowley, Merrill J, Turer, Muhammed, Van Damme, Marie-Paule, Wood, Bayden, Zuasti, Beltzane Biurrun   +8 more
core   +2 more sources

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

Matrix Biology, 2015
We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores.
Iozzo, Renato V., Schäfer, Liliana
openaire   +5 more sources