Results 1 to 10 of about 156,238 (329)
Seminars in Cell & Developmental Biology, 2001 The predominant proteoglycan present in cartilage is the large chondroitin sulfate proteoglycan 'aggrecan'. Following its secretion, aggrecan self-assembles into a supramolecular structure with as many as 50 monomers bound to a filament of hyaluronan.
C B, Knudson, W, Knudson
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Molecular BioSystems, 2012 Proteoglycans (PGs) are among the most structurally complex biomacromolecules in nature. They are present in all animal cells and frequently exert their critical biological functions through interactions with protein ligands and receptors. PGs are comprised of a core protein to which one or multiple, heterogeneous, and polydisperse glycosaminoglycan ...
Lingyun, Li +2 more
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Pharmaceuticals, 2022 Cisplatin-based chemotherapy has been effectively used to treat oral cancer, but treatment often fails owing to the development of drug resistance. However, the important gene expression alterations associated with these resistances remain unclear.
Hyeong Sim Choi +2 more
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Intracellular proteoglycans [PDF]
Biochemical Journal, 2004 Proteoglycans (PGs) are proteins with glycosaminoglycan chains, are ubiquitously expressed and have a wide range of functions. PGs in the extracellular matrix and on the cell surface have been the subject of extensive structural and functional studies.
Svein Olav, Kolset +2 more
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Diagnostics, 2022 The aim of this study was the preliminary assessment of a new cationic contrast agent, the CA4+, via the analysis of spatial distribution in cartilage of ex vivo bovine samples, at micrometer and millimeter scale.
Simone Fantoni +11 more
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Lumican in Carcinogenesis—Revisited
Biomolecules, 2021 Carcinogenesis is a multifactorial process with the input and interactions of environmental, genetic, and metabolic factors. During cancer development, a significant remodeling of the extracellular matrix (ECM) is evident.
Eirini-Maria Giatagana +4 more
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Alterations of Extracellular Matrix Components in the Course of Juvenile Idiopathic Arthritis
Metabolites, 2021 Juvenile idiopathic arthritis (JIA) is the most common group of chronic connective tissue diseases in children that is accompanied by joint structure and function disorders.
Magdalena Wojdas +2 more
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Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis [PDF]
, 2012 Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Adriana T. Larregina +7 more
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Proteoglycans as Mediators of Cancer Tissue Mechanics
Frontiers in Cell and Developmental Biology, 2020 Proteoglycans are a diverse group of molecules which are characterized by a central protein backbone that is decorated with a variety of linear sulfated glycosaminoglycan side chains.
Anna Barkovskaya +8 more
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JOR Spine, 2022 Introduction Diabetes has long been implicated as a major risk factor for intervertebral disc (IVD) degeneration, interfering with molecular signaling and matrix biochemistry, which ultimately aggravates the progression of the disease.
Marianne Lintz +3 more
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