Results 21 to 30 of about 100,368 (249)

Nondestructive fluorescence lifetime imaging and time-resolved fluorescence spectroscopy detect cartilage matrix depletion and correlate with mechanical properties [PDF]

European Cells & Materials, 2018
Tissue engineers utilize a battery of expensive, time-consuming and destructive techniques to assess the composition and function of engineered tissues.
AK Haudenschild, BE Sherlock, X Zhou, JC Hu, JK Leach, L Marcu, KA Athanasiou   +6 more
doaj   +1 more source

Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells. [PDF]

Nat Chem Biol
Mammalian cells receive signaling instructions through interactions on their surfaces. Proteoglycans are critical to these interactions, carrying long glycosaminoglycans that recruit signaling molecules. Biosynthetic redundancy in the first glycosylation
Li Z, Chawla H, Di Vagno L, Ní Cheallaigh A, Critcher M, Sammon D, Gonzalez-Rodriguez E, Briggs DC, Chung N, Chang V, Mahoney KE, Cioce A, Bineva-Todd G, Wang PY, Liu YC, Murphy LD, Chen YH, Narimatsu Y, Miller RL, Willems LI, Malaker SA, Huang ML, Miller GJ, Hohenester E, Schumann B.   +24 more
europepmc   +3 more sources

Hydrophobic interaction chromatography of fibroblast proteoglycans

, 1993
We have investigated the hydrophobic properties of human skin fibroblast proteoglycans and related material by affinity chromatography on Octyl-Sepharose CL-4B in 4 M guanidinium hydrochloride (GdnHCl).
Schmidtchen, Artur,, Lund University., Fransson, Lars-Åke,   +2 more
core   +2 more sources

Involvement of proteoglycans in tendinopathy [PDF]

, 2011
A major feature of chronic tendinopathy is a change in the nature and organisation of the extracellular matrix of tendon. Increased levels of proteoglycans have been shown in the extracellular matrix of tendinopathic tendons and these appear to influence
Samiric, T., Cook, J., Handley, C. J., Ilic, M. Z., Parkinson, J.   +4 more
core   +1 more source

Dentin proteoglycans: an immunocytochemical FEISEM study. [PDF]

, 2002
Dentin proteoglycans are fundamental constituents of the dentin matrix and are distributed ubiquitously both in dentin and cement. They have several important functional properties; in particular, they have a fundamental role in the maintenance and the ...
MAZZOTTI G, BRESCHI L, PERDIGAO J., LOPES M, FALCONI M, GOBBI, PIETRO   +5 more
core   +1 more source

A brief elevation of serum amyloid A is sufficient to increase atherosclerosis[S]

Journal of Lipid Research, 2015
Serum amyloid A (SAA) has a number of proatherogenic effects including induction of vascular proteoglycans. Chronically elevated SAA was recently shown to increase atherosclerosis in mice.
Joel C. Thompson, Colton Jayne, Jennifer Thompson, Patricia G. Wilson, Meghan H. Yoder, Nancy Webb, Lisa R. Tannock   +6 more
doaj   +1 more source

Esophageal Cancer Development: Crucial Clues Arising from the Extracellular Matrix

Cells, 2020
In the last years, the extracellular matrix (ECM) has been reported as playing a relevant role in esophageal cancer (EC) development, with this compartment being related to several aspects of EC genesis and progression.
Antonio Palumbo, Nathalia Meireles Da Costa, Bruno Pontes, Felipe Leite de Oliveira, Matheus Lohan Codeço, Luis Felipe Ribeiro Pinto, Luiz Eurico Nasciutti   +6 more
doaj   +1 more source

Global impact of proteoglycan science on human diseases

iScience, 2023
Summary: In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological ...
Christopher Xie, Liliana Schaefer, Renato V. Iozzo   +2 more
doaj   +1 more source

Heparan Sulfate Proteoglycans as Multifunctional Cell Regulators: Cell Surface Receptors

, 2011
Proteoglycans are macromolecules expressed on the cell surfaces and in the extracellular matrix of most animal tissues (Annu Rev Biochem 68:729-777, 1999; Int Rev Cell Mol Biol 276:105-159, 2009).
Jin-ping Li, Spillmann, Dorothe,, Dorothe Spillmann, Li, Jin-ping,   +3 more
core   +1 more source

Retinal Proteoglycans Act as Cellular Receptors for Basement Membrane Assembly to Control Astrocyte Migration and Angiogenesis

Cell Reports, 2016
The basement membrane is crucial for cell polarity, adhesion, and motility, but how it is assembled on the cell surface remains unclear. Here, we find that ablation of glycosaminoglycan (GAG) side chains of proteoglycans in the neuroretina disrupts the ...
Chenqi Tao, Xin Zhang
doaj   +1 more source