Results 101 to 110 of about 132,430 (262)
Animal Models and Experimental Medicine, EarlyView.Fuke Huahuang formulation (FHF) is used to treat vaginitis, and it exerts a promising anti‐inflammatory effect in clinical use. However, the detailed components and mechanisms of FHF for treating vaginitis remain unreported, and further preclinical evaluation is required to reveal its potential pharmacological activities against vaginitis.
Huiyu Liu +5 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.This study evaluates the role of elastin in vascular response 28 days after balloon angioplasty using uncoated and paclitaxel‐coated balloons in a healthy porcine model. The results show higher elastin content in external femoral arteries, which is inversely correlated with vascular injury, inflammation, smooth muscle cell loss, proteoglycan and fibrin
María Gracia de Garnica García +7 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Chemically modified graphene oxide nanocarriers provide a targeted lung cancer gene therapy platform. In a 3D tumor microenvironment model, these nanocarriers deliver therapeutic genes, regulate immune markers, and induce apoptosis in cancer cells. Combined gene delivery enhances cancer cell elimination, demonstrating the potential of this approach for
Francesca Grilli +3 more
wiley +1 more source
Functional Synovium‐Based 3D Models in the Context of Human Disease and Inflammation
Advanced NanoBiomed Research, EarlyView.The synovium is key to joint function but is often affected by diseases like rheumatoid arthritis. Finding better treatments is challenging because current lab models do not fully mimic real tissues. New 3D technologies, like bioprinting, offer better methods to study these diseases, improve drug testing, and develop personalized treatments, bringing ...
Amelia Heslington +3 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.The power of time‐of‐flight secondary ion mass spectrometry‐partial least square regression to detect interleukin‐8, a chemokine involved in inflammation and cancer, down to mass fractions of 1 ppm within biopolymer matrices, including Matrigel and glycosaminoglycan‐based hydrogels, is demonstrated.
Ralf Zimmermann +4 more
wiley +1 more source
Combined Chondroitinase and KLF7 Expression Reduce Net Retraction of Sensory and CST Axons from Sites of Spinal Injury [PDF]
, 2017 Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations.
Blackmore, Murray G. +4 more
core +1 more source
The Anatomical Record, EarlyView.Abstract The pygmy sperm whale (Kogia breviceps) possesses an exocrine gland associated with its false gill slit pigmentation pattern. The cervical gill slit gland is a compound tubuloalveolar gland that produces a holocrine secretion and displays maturational changes in size and secretory histology. While the morphology of the cervical gill slit gland
Tiffany F. Keenan +13 more
wiley +1 more source
Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. [PDF]
, 2019 Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis. Its expression is regulated by the bone morphogenetic protein 6 (BMP6)/SMAD1/5/8 pathway and by the proinflammatory cytokine interleukin 6 (IL6).
Anower-E-Khuda, Ferdous +8 more
core
Arthritis &Rheumatology, EarlyView.Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu +11 more
wiley +1 more source