Results 101 to 110 of about 189,785 (400)
Journal of Cardiovascular Development and Disease, 2018 Experimental and clinical data indicate that the initiation and progress of atherosclerosis and its clinical manifestations are first caused by circulating apoB-100 lipoproteins that enter and are retained in the arterial intima.
Eva Hurt-Camejo, Germán Camejo
doaj +1 more source
Reduced Sulfation Enhanced Oxytosis and Ferroptosis in Mouse Hippocampal HT22 Cells
Biomolecules, 2020 Sulfation is a common modification of extracellular glycans, tyrosine residues on proteins, and steroid hormones, and is important in a wide variety of signaling pathways.
Haruna Nagase +4 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song +8 more
wiley +1 more source
Global impact of proteoglycan science on human diseases
iScience, 2023 Summary: In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological ...
Christopher Xie +2 more
doaj
End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans [PDF]
, 2010 Glycosaminoglycans are sulfated polysaccharides that play important roles in fundamental biological processes, such as cell division, viral invasion, cancer and neuroregeneration.
Brown, Joshua M. +6 more
core +2 more sources
Proteoglycans in the nervous system [PDF]
Current Opinion in Neurobiology, 1993 Proteoglycans are ubiquitous cell-surface and secreted glycoproteins that are involved in diverse cellular behaviors. The identities of several nervous system proteoglycans, including many of the major species in the mammalian brain, have recently come to light.
openaire +5 more sources
Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function
Advanced Functional Materials, EarlyView.Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh +3 more
wiley +1 more source
A brief elevation of serum amyloid A is sufficient to increase atherosclerosis[S]
Journal of Lipid Research, 2015 Serum amyloid A (SAA) has a number of proatherogenic effects including induction of vascular proteoglycans. Chronically elevated SAA was recently shown to increase atherosclerosis in mice.
Joel C. Thompson +6 more
doaj
Melanocyte Transformation Associated with Substrate Adhesion Impediment
Neoplasia: An International Journal for Oncology Research, 2006 Exclude experimental models of malignant transformation employ chemical and physical carcinogens or genetic manipulations to study tumor progression.
Sueli M. Oba-Shinjo +10 more
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The Cardiac Syndecan-2 Interactome
Frontiers in Cell and Developmental Biology, 2020 The extracellular matrix (ECM) is important in cardiac remodeling and syndecans have gained increased interest in this process due to their ability to convert changes in the ECM to cell signaling.
Sabrina Bech Mathiesen +7 more
doaj +1 more source