Regulated Expression and Subcellular Localization of Syndecan Heparan Sulfate Proteoglycans and the Syndecan-Binding Protein CASK/LIN-2 during Rat Brain Development [PDF]
, 1999 Yi‐Ping Hsueh, Morgan Sheng
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Advanced Science, EarlyView.This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li +11 more
wiley +1 more source
Melanoma Chondroitin Sulfate Proteoglycan Regulates Matrix Metalloproteinase-dependent Human Melanoma Invasion into Type I Collagen [PDF]
, 2001 Joji Iida +6 more
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Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8
Advanced Science, EarlyView.Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong +11 more
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High-molecular-weight proteins of nontypeable Haemophilus influenzae mediate bacterial adhesion to cellular proteoglycans [PDF]
, 1994 Gary J. Noel +2 more
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Advanced Science, EarlyView.This research introduces a novel approach to enhance neuroregeneration following Traumatic Brain Injury (TBI). Extracellular Vesicles (EVs) are isolated from human neural progenitor cells under hypoxic conditions, leading to enhanced expression of neurogenic and angiogenic factors.
Joshua B. Stein +9 more
wiley +1 more source
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Hierarchical nanomechanics of collagen microfibrils [PDF]
, 2010 Collagen constitutes one third of the human proteome, providing mechanical stability, elasticity and strength to connective tissues. Collagen is also the dominating material in the extracellular matrix (ECM) and is thus crucial for cell differentiation ...
Alberto Redaelli +3 more
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Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells [PDF]
, 2016 Matthew R. Reynolds +9 more
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Advanced Science, EarlyView.This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun +15 more
wiley +1 more source