Results 161 to 170 of about 189,785 (400)
Matrix proteoglycans as effector molecules for epithelial cell function
European Respiratory Review, 2005 Matrix proteoglycans are complex molecules composed of a core protein and glycosaminoglycan side chains. Once thought to be the molecular glue providing structural support and imparting biomechanical properties to lung tissue, it is now apparent that ...
C. W. Frevert, P. L. Sannes
doaj
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
Journal of Lipid Research, 2002 Atherosclerosis is the main cause of morbidity and mortality in diabetes, yet the underlying mechanisms remain unclear. Retention of atherogenic lipoproteins by vascular proteoglycans is thought to play a key role in the development of atherosclerotic ...
Lisa R. Tannock +3 more
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Combined Chondroitinase and KLF7 Expression Reduce Net Retraction of Sensory and CST Axons from Sites of Spinal Injury [PDF]
, 2017 Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations.
Blackmore, Murray G. +4 more
core +1 more source
EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells
Advanced Science, EarlyView.ALPL+PDGFD+ (AP+) cells are distinct calvarial periosteal stem cells (PeSCs) with diminished postnatal activity. EGR1 drives PeSCs development via BMP signaling through its Znf2 domain and activates them via CTNNB1/WNT10B signaling through its Znf2/3 domains.
Yang Li +15 more
wiley +1 more source
Interactions of an intact proteoglycan and its fragments with basic homopolypeptides in dilute aqueous solution [PDF]
, 1974 Robert A. Gelman +2 more
openalex +1 more source
Advanced Science, EarlyView.This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang +13 more
wiley +1 more source
Smith-degraded cartilage proteoglycan as an acceptor for xylosyl transfer [PDF]
, 1971 John Baker +2 more
openalex +1 more source
Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity
Advanced Science, EarlyView.Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi +10 more
wiley +1 more source
Effect of Trimethylcolchicinic Acid on the Synthesis and Excretion of Proteoglycans in Tissue Culture [PDF]
, 1975 G Lorans +3 more
openalex +1 more source