Results 11 to 20 of about 189,785 (400)
Evidence for the role of proteoglycans in cation-mediated gene transfer. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1996 We report evidence that gene complexes, consisting of polycations and plasmid DNA enter cells via binding to membrane-associated proteoglycans. Treatment of HeLa cells with sodium chlorate, a potent inhibitor of proteoglycan sulfation, reduced luciferase
Kimberly A. Mislick, J. Baldeschwieler
semanticscholar +3 more sources
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Matrix Biology, 2015 We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores.
R. Iozzo, L. Schaefer
semanticscholar +6 more sources
Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model [PDF]
, 2012 Decorin, a member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis by directly targeting and antagonizing multiple receptor tyrosine kinases, such as the EGFR and ...
Buraschi, Simone +10 more
core +15 more sources
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis
Frontiers in Cell and Developmental Biology, 2020 Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw. They represent not only the primary tumor site, but also potential metastatic lesions, and could thus be an attractive supplement for cancer diagnostics.
Theresa D. Ahrens +8 more
semanticscholar +1 more source
Proteoglycans and Osteolysis [PDF]
, 2011 Osteolysis is a complex mechanism resulting from an exacerbated activity of osteoclasts associated or not with a dysregulation of osteoblast metabolism leading to bone loss. This bone defect is not compensated by bone apposition or by apposition of bone matrix with poor mechanical quality.
Marc Baud'huin +13 more
openaire +4 more sources
Alterations of Extracellular Matrix Components in the Course of Juvenile Idiopathic Arthritis
Metabolites, 2021 Juvenile idiopathic arthritis (JIA) is the most common group of chronic connective tissue diseases in children that is accompanied by joint structure and function disorders.
Magdalena Wojdas +2 more
doaj +1 more source
Molecules, 2011 Four proteoglycans were sequentially extracted from Hypsizygus marmoreus using 0.1 M NaOH (alkali-soluble proteoglycans [F1] and alkali-insoluble proteoglycans [F3]) and 0.1 M HCl (acid-soluble proteoglycans [F2] and acid-insoluble proteoglycans [F4 ...
Hee Mun Chae +3 more
doaj +1 more source
Lumican in Carcinogenesis—Revisited
Biomolecules, 2021 Carcinogenesis is a multifactorial process with the input and interactions of environmental, genetic, and metabolic factors. During cancer development, a significant remodeling of the extracellular matrix (ECM) is evident.
Eirini-Maria Giatagana +4 more
doaj +1 more source
Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?
Viruses, 2019 Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular matrix proteins.
V. Cagno +3 more
semanticscholar +1 more source
Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. [PDF]
, 2006 Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic ...
Bishop, Joseph R +4 more
core +2 more sources