Results 21 to 30 of about 152,765 (288)

Glycosaminoglycans and Proteoglycans

open access: yesPharmaceuticals, 2018
In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan,
Vitor H. Pomin, Barbara Mulloy
doaj   +1 more source

Molecular Properties of Water-Unextractable Proteoglycans from Hypsizygus marmoreus and Their in Vitro Immunomodulatory Activities

open access: yesMolecules, 2011
Four proteoglycans were sequentially extracted from Hypsizygus marmoreus using 0.1 M NaOH (alkali-soluble proteoglycans [F1] and alkali-insoluble proteoglycans [F3]) and 0.1 M HCl (acid-soluble proteoglycans [F2] and acid-insoluble proteoglycans [F4 ...
Hee Mun Chae   +3 more
doaj   +1 more source

The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs

open access: yesJOR Spine, 2022
Introduction Diabetes has long been implicated as a major risk factor for intervertebral disc (IVD) degeneration, interfering with molecular signaling and matrix biochemistry, which ultimately aggravates the progression of the disease.
Marianne Lintz   +3 more
doaj   +1 more source

Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. [PDF]

open access: yes, 2006
Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic ...
Bishop, Joseph R   +4 more
core   +2 more sources

Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL

open access: yesJournal of Lipid Research, 2003
Retention of LDL in the artery intima is mediated by extracellular matrix proteoglycans and plays an important role in the initiation of atherosclerosis.
C. Daniel Meyers   +3 more
doaj   +1 more source

Evidence for the role of proteoglycans in cation-mediated gene transfer [PDF]

open access: yes, 1996
We report evidence that gene complexes, consisting of polycations and plasmid DNA enter cells via binding to membrane-associated proteoglycans. Treatment of HeLa cells with sodium chlorate, a potent inhibitor of proteoglycan sulfation, reduced luciferase
Baldeschwieler, John D.   +1 more
core   +1 more source

Roles of Chondroitin Sulfate Proteoglycans as Regulators of Skeletal Development

open access: yesFrontiers in Cell and Developmental Biology, 2022
The extracellular matrix (ECM) is critically important for most cellular processes including differentiation, morphogenesis, growth, survival and regeneration.
Nancy B. Schwartz   +2 more
doaj   +1 more source

Proteoglycans and neuronal migration in the cerebral cortex during development and disease

open access: yesFrontiers in Neuroscience, 2015
Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many proteins including growth factors, chemokines, axon guidance molecules,
Nobuaki eMaeda
doaj   +1 more source

大腸菌を用いたフォスファカン(コンドロイチン硫酸プロテオグリカン)の融合コア蛋白の発現条件の検討 [PDF]

open access: yes, 1996
Optimal conditions for expressing a specific region of core protein of phosphacan, a chondroitin sulfate proteoglycan known as receptor type protein tyrosine phosphatase, as fusion protein with glutathione S-transferase (GST) in E.coli were examined. DNA
Ito, Sekiko, Okamoto, Motoi
core   +1 more source

The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma

open access: yesBMC Cancer, 2009
Background Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland. Recurrence or/and early metastasis is its biological properties.
Li Hexiang   +5 more
doaj   +1 more source

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