Results 41 to 50 of about 141,588 (181)

Spatial and temporal changes in the distribution of proteoglycans during avian neural crest development [PDF]

, 1991
In this study, we describe the distribution of various classes of proteoglycans and their potential matrix ligand, hyaluronan, during neural crest development in the trunk region of the chicken embryo.
Bronner-Fraser, Marianne, Domingo, Carmen, Krotoski, Danuta, Lallier, Thomas, Perris, Roberto, Sorrell, Michael   +5 more
core  

Metabolic response of human osteoarthritic cartilage to biochemically characterized collagen hydrolysates [PDF]

, 2017
The most frequent disease of the locomotor system is osteoarthritis (OA), which, as a chronic joint disease, might benefit more from nutrition than acute illnesses.
Gazova, Zuzana, Kordelle, Jens, Lochnit, Guenter, Schadow, Saskia, Siebert, Hans-Christian, Simons, Viktor S., Steinmeyer, Juergen   +6 more
core   +2 more sources

Atherosclerosis: from lipid-lowering and anti-inflammatory therapies to targeting arterial retention of ApoB-containing lipoproteins

Frontiers in Immunology
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, fibrous elements, and cellular debris in the blood vessels. The response-to-retention hypothesis, the leading theory on the pathogenesis of this cardiovascular
Gala Araujo, Leidy Marian Valencia, Agata Martin-Ozimek, Yosdel Soto, Yosdel Soto, Spencer D. Proctor   +5 more
doaj   +1 more source

Biglycan-mediated upregulation of MHC class I expression in HER-2/neu-transformed cells

OncoImmunology, 2018
The extracellular matrix protein biglycan (BGN) has oncogenic or tumor suppressive potential depending on the cellular origin. HER-2/neu overexpression in murine fibroblasts and human model systems is inversely correlated with BGN expression.
Karthikeyan Subbarayan, Sandra Leisz, Claudia Wickenhauser, Daniel Bethmann, Chiara Massa, André Steven, Barbara Seliger   +6 more
doaj   +1 more source

Hair follicle proteoglycans

Journal of Investigative Dermatology, 1993
Proteoglycans are polymorphic macromolecules present in all mammalian tissues, including the skin and its appendages. They consist of a core protein to which one or more glycosaminoglycan chains are covalently attached. Broadly, they can be divided into classes based on location and core protein structure.
openaire   +2 more sources

Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization [PDF]

, 2009
Initiation of mineralization during endochondral ossification is a multistep process and has been assumed to correlate with specific interactions of annexins A5 and A6 and collagens.
Anderson, Anja Niehoff, Balcerzak, Balcerzak, Belluoccio, Bent Brachvogel, Berendes, Blumbach, Brachvogel, Brachvogel, Brachvogel, Bradford, Budde, Christian Frie, Collett, Damazo, Daniele Belluoccio, DiCesare, Ernst Pöschl, Friedericke Pausch, Genge, Genge, Gerke, Girkontaite, Haut Donahue, Hawkins, Hazarika, Hikiji, Hofmann, Ivan Grskovic, John F Bateman, Julia Etich, Karsenty, Karsenty, Kim, Kirsch, Kirsch, Kirsch, Koopman, Kwan, Ling, Livak, Morgan, Murshed, Pfaffl, Rety, Romeis, Sabrina Rosenbaum, Schmitz, Srivastava, Srivastava, Stephen E Moss, Ursula Schlötzer-Schrehardt, Van Gelder, White   +54 more
core   +1 more source

Tumor-Associated Extracellular Matrix: How to Be a Potential Aide to Anti-tumor Immunotherapy?

Frontiers in Cell and Developmental Biology, 2021
The development of cancer immunotherapy, particularly immune checkpoint blockade therapy, has made major breakthroughs in the therapy of cancers. However, less than one-third of the cancer patients obtain significant and long-lasting therapeutic effects ...
Yingying He, Yingying He, Tao Liu, Tao Liu, Shuang Dai, Zihan Xu, Li Wang, Feng Luo   +7 more
doaj   +1 more source

Biglycan : a multivalent proteoglycan providing structure and signals [PDF]

, 2013
Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule.
Năstase, Mădălina-Viviana, Schäfer, Liliana, Young, Marian F.   +2 more
core  

Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. [PDF]

, 2017
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and ...
Cohen IR, Douglass S, Kalas W, Mathiak M, Onita T, Zhu YH   +5 more
core   +2 more sources

Prevention of TGFβ induction attenuates angII-stimulated vascular biglycan and atherosclerosis in Ldlr−/− mice1

Journal of Lipid Research, 2013
Angiotensin II (angII) accelerates atherosclerosis, but the mechanisms are not fully understood. The aim of this study was to determine whether TGFβ is required for angII-induced atherosclerosis.
Tao Tang, Patricia G. Wilson, Joel C. Thompson, Christina Nelson, Meghan H. Yoder, Lisa R. Tannock   +5 more
doaj   +1 more source