Results 51 to 60 of about 17,769 (248)
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Matrix Biology, 2015 We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores.
Iozzo, Renato V., Schäfer, Liliana
openaire +3 more sources
, 2012 Mast cells are versatile effector cells of the immune system, contributing to both innate and adaptive immunity toward pathogens but also having profound detrimental activities in the context of inflammatory disease.
Melo, Fabio rabelo, +3 more
core +1 more source
Advanced Functional Materials, EarlyView.Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou +6 more
wiley +1 more source
Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth
eLife, 2022 The Ewing sarcoma family of tumors is a group of malignant small round blue cell tumors (SRBCTs) that affect children, adolescents, and young adults.
Elena Vasileva +3 more
doaj +1 more source
Proteoglycans: Road Signs for Neurite Outgrowth [PDF]
, 2014 Proteoglycans in the central nervous system play integral roles as traffic signals for the direction of neurite outgrowth. This attribute of proteoglycans is a major factor in regeneration of the injured central nervous system.
Beller, Justin A., Snow, Diane M.
core +1 more source
Advanced Functional Materials, EarlyView.This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu +14 more
wiley +1 more source
Heparan Sulfate Proteoglycans in Tauopathy [PDF]
, 2022 Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis.
Lauren Gandy +15 more
core +1 more source
Advanced Healthcare Materials, EarlyView.A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi +10 more
wiley +1 more source
Hydrophobic interaction chromatography of fibroblast proteoglycans
, 1993 We have investigated the hydrophobic properties of human skin fibroblast proteoglycans and related material by affinity chromatography on Octyl-Sepharose CL-4B in 4 M guanidinium hydrochloride (GdnHCl).
Schmidtchen, Artur, +2 more
core +2 more sources
Glycoproteomics incursions into the realm of proteoglycans [PDF]
, 2017 The term proteoglycan encompasses a heterogeneous group of heavilymodified metazoan glycoproteins that are involved in fundamental biological processes. They are essential for embryonic development and play important roles in tissue organization and cell
Gómez Toledo, Alejandro
core +1 more source