Results 81 to 90 of about 152,765 (288)

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

open access: yesAdvanced Functional Materials, EarlyView.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput   +5 more
wiley   +1 more source

Mechanically Tunable Bone Scaffolds: In Vivo Hardening of 3D‐Printed Calcium Phosphate/Polycaprolactone Inks

open access: yesAdvanced Functional Materials, EarlyView.
A 3D bone scaffold with osteogenic properties and capable of hardening in vivo is developed. The scaffold is implanted in a ductile state, and a phase transformation of the ceramic induces the stiffening and strengthening of the scaffold in vivo. Abstract Calcium phosphate 3D printing has revolutionized customized bone grafting.
Miguel Mateu‐Sanz   +7 more
wiley   +1 more source

Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons

open access: yesJournal of Neuroinflammation, 2019
Background Mast cells (MCs) in the brain can respond to environmental cues and relay signals to neurons that may directly influence neuronal electrical activity, calcium signaling, and neurotransmission.
Juan Antonio Flores   +6 more
doaj   +1 more source

Syndecan-1 Promotes Streptococcus pneumoniae Corneal Infection by Facilitating the Assembly of Adhesive Fibronectin Fibrils

open access: yesmBio, 2020
Subversion of heparan sulfate proteoglycans (HSPGs) is thought to be a common virulence mechanism shared by many microbial pathogens. The prevailing assumption is that pathogens co-opt HSPGs as cell surface attachment receptors or as inhibitors of innate
Akiko Jinno   +3 more
doaj   +1 more source

Self-diffusion of polymers in cartilage as studied by pulsed field gradient NMR [PDF]

open access: yes, 2002
Pulsed field gradient (PFG) nuclear magnetic resonance (NMR) was used to investigate the self-diffusion behaviour of polymers in cartilage. Polyethylene glycol and dextran with different molecular weights and in different concentrations were used as ...
Arnold, K.   +5 more
core   +2 more sources

Nanoparticles Decorated Nanotubes: Advanced Local Therapies From Anodized Nanoengineered Titanium Implants

open access: yesAdvanced Functional Materials, EarlyView.
This comprehensive review explores therapeutic titanium implants designed to enhance integration and provide superior antibacterial efficacy. It is focused on anodized titanium implants with titania nanotubes (TNTs) loaded with nanoparticles (NPs) for local therapeutic release, enhancing bioactivity and bactericidal functions.
Divya Chopra   +5 more
wiley   +1 more source

Healthy but not osteoarthritic human meniscus-derived matrix scaffolds promote meniscus repair

open access: yesFrontiers in Bioengineering and Biotechnology
Meniscus tissue is commonly injured due to sports-related injuries and age-related degeneration and approximately 50% of individuals with a meniscus tear will develop post-traumatic osteoarthritis (PTOA).
Saman Firoozi   +8 more
doaj   +1 more source

Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules

open access: yesFrontiers in Immunology, 2018
Mast cells (MCs) are characterized by an abundance of lysosome-like secretory granules filled with immunomodulatory compounds including histamine, cytokines, lysosomal hydrolases, MC-restricted proteases, and serglycin proteoglycans.
Jun Mei Hu Frisk   +5 more
doaj   +1 more source

Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

open access: yeseLife, 2020
The umbilical artery lumen closes rapidly at birth, preventing neonatal blood loss, whereas the umbilical vein remains patent longer. Here, analysis of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan ...
Sumeda Nandadasa   +16 more
doaj   +1 more source

Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx [PDF]

open access: yes, 2008
A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and ...
Becker, Bernhard F.   +6 more
core   +1 more source

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