Results 101 to 110 of about 17,769 (248)
Deep Learning Prediction of O‐Glycopeptide Tandem Mass Spectra Enhances O‐Glycoproteomics
Advanced Science, EarlyView.DeepGPO integrates Transformer and graph neural networks with tailored training strategies, including data augmentation, loss re‐weighting, and pre‐training, to achieve high‐quality O‐glycopeptide MS/MS spectra prediction. The predicted MS/MS spectra are used to localize O‐glycosylation sites from HCD MS/MS data, enhancing O‐glycoproteomics analysis ...
Yu Zong, Yuxin Wang, Liang Qiao
wiley +1 more source
Editorial: Molecules of the extracellular matrix as cancer targets
Frontiers in Oncology, 2022 Nikos K. Karamanos +2 more
doaj +1 more source
The extracellular matrix in multiple sclerosis: an update
Brazilian Journal of Medical and Biological Research, 2001 Extracellular matrix (ECM) molecules play important roles in the pathobiology of the major human central nervous system (CNS) inflammatory/demyelinating disease multiple sclerosis (MS). This mini-review highlights some recent work on CNS endothelial cell
R.A. Sobel
doaj +1 more source
Advanced Science, EarlyView.Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu +7 more
wiley +1 more source
Specificity of lipoprotein lipase binding to endothelial cells.
Journal of Lipid Research, 1993 Lipoprotein lipase (LPL) hydrolyzes circulating lipoprotein triglyceride molecules while it is associated with the luminal surface of capillary endothelial cells. The precise molecular mechanism by which LPL attaches to these cells is unknown.
MF Stins +3 more
doaj +1 more source
Consequences of Reduced Versican Expression in Embryonic Chick Synovial Joint Development
, 2012 The different mechanisms involved in vertebrate synovial joint development are actively being uncovered. A variety of studies have thus far discovered the involvement of several large molecules in the processes of joint development and cavitation.
Nagchowdhuri, Partha Sarathi +1 more
core
Proteoglycans on bone tumor development
, 2010 Proteoglycans, extracellular matrix components, exert several activities on bone cells and seem crucial for maintaining an appropriate number of osteoblasts and osteoclasts.
Velasco, C.R. +9 more
core +1 more source
Advanced Science, EarlyView.ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao +6 more
wiley +1 more source
Endocrinology, Diabetes & MetabolismIntroduction Previous studies have linked Syndecans (SDCs) to hypertension (HTN), BMI and the prevalence of coronary artery disease (CAD). The relationship between SDCs and metabolic syndrome (MetS) has not been explored.
Shima Tavalaie +9 more
doaj +1 more source
Proteoglycans and Immunobiology of Cancer—Therapeutic Implications
Frontiers in Immunology, 2019 Disparity during the resolution of inflammation is closely related with the initiation and progression of the tumorigenesis. The transformed cells, through continuously evolving interactions, participate in various exchanges with the surrounding ...
George Tzanakakis +4 more
doaj +1 more source