Results 41 to 50 of about 391,640 (387)
Pericellular proteolysis in cancer [PDF]
Genes & Development, 2014 Pericellular proteases have long been associated with cancer invasion and metastasis due to their ability to degrade extracellular matrix components. Recent studies demonstrate that proteases also modulate tumor progression and metastasis through highly regulated and complex processes involving cleavage, processing, or shedding of cell adhesion ...
Johanna A. Joyce, Lisa Sevenich
openaire +2 more sources
Regulation of Antimycin Biosynthesis Is Controlled by the ClpXP Protease
mSphere, 2020 The survival of any microbe relies on its ability to respond to environmental change. Use of extracytoplasmic function (ECF) RNA polymerase sigma (σ) factors is a major strategy enabling dynamic responses to extracellular signals.
Bohdan Bilyk +4 more
doaj +1 more source
A versatile ceramic capillary membrane reactor system for continuous enzyme‐catalyzed hydrolysis
Engineering in Life Sciences, 2021 As an alternative to classical batch processes, enzyme‐catalyzed hydrolysis can also be carried out continuously. To facilitate this, a continuous ceramic capillary membrane reactor system (CCCMRS) was developed which can be operated with various ...
Lorn Messner +4 more
doaj +1 more source
Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]
, 2017 Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura +5 more
core +1 more source
Molecular Biology of the Cell, 1999 The unfolded protein response (UPR) controls the levels of molecular chaperones and enzymes involved in protein folding in the endoplasmic reticulum (ER). We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report
K. Haze +4 more
semanticscholar +1 more source
Communications Biology, 2018 The androgen receptor is a major driver of prostate cancer and inhibition of its transcriptional activity using competitive antagonists, such as enzalutamide remains a frontline therapy for prostate cancer management.
J. Salami +10 more
semanticscholar +1 more source
Limited proteolysis in the investigation of beta2-microglobulin amyloidogenic and fibrillar states. [PDF]
, 2005 Amyloid fibrils of patients treated with regular haemodialysis essentially consists of β2-microglobulin (β2-m) and its truncated species ΔN6β2-m lacking six residues at the amino terminus.
AMORESANO, ANGELA +4 more
core +1 more source
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
Genes & Development, 1998 The activities of cyclin D-dependent kinases serve to integrate extracellular signaling during G1 phase with the cell-cycle engine that regulates DNA replication and mitosis. Induction of D-type cyclins and their assembly into holoenzyme complexes depend
J. Diehl, M. Cheng, M. Roussel, C. Sherr
semanticscholar +1 more source
Pakistan Journal of Biological Sciences, 2001 In this research, the degree of proteolysis and correlations among the casein fractions, pH, soluble nitrogen, and ripening index in Golot cheese were investigated.
Yazici, F., Dervisoglu, M.
openaire +5 more sources
Methylated DNMT1 and E2F1 Are Targeted for Proteolysis by L3MBTL3 and CRL4DCAF5 Ubiquitin Ligase [PDF]
, 2018 Many non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves ...
Alejo, Salvador +7 more
core +3 more sources