Results 91 to 100 of about 461,354 (348)
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Glycomic analysis of high density lipoprotein shows a highly sialylated particle. [PDF]
, 2014 Many of the functional proteins and lipids in high density lipoprotein (HDL) particles are potentially glycosylated, yet very little is known about the glycoconjugates of HDL.
German, J Bruce +6 more
core +1 more source
Proteomics of the Spermatozoon [PDF]
Balkan Journal of Medical Genetics, 2012 ABSTRACT The study of the sperm proteins is crucial for understanding its normal function and alterations in infertile patients. The sperm is a highly specialized cell with a very large flagella, with little cytoplasm and a highly condensed nucleus. The most abundant proteins in the nucleus of mammalian sperm are the protamines. The main functions
JL Ballescá, R Oliva
openaire +4 more sources
COVID‐19 diagnostic testing: Technology perspective
Clinical and Translational Medicine, 2020 The corona virus disease 2019 (COVID‐19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
Meng Xu +10 more
doaj +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases [PDF]
, 2016 Purpose of review: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years.
Magalhães, Pedro +2 more
core +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009 Defects in lysosomal function have been associated with numerous monogenic human diseases typically classified as lysosomal storage diseases. However, there is increasing evidence that lysosomal proteins are also involved in more widespread human diseases including cancer and Alzheimer disease.
Torben Lübke +4 more
openaire +3 more sources
Proteomics in Diagnostics [PDF]
Disease Markers, 2004 For many diseases, such as heart disease and cancer, early detection plays a pivotal role in the survival rate of the patient. When detected early, many such lethal diseases can be effectively treated with existing remedies. The difficulty remains, however, how to effectively detect such conditions at the earliest possible stage with a high enough ...
Timothy D. Veenstra, Sudhir Srivastava
openaire +3 more sources
Frontiers in Genetics, 2023 Multi-omics data integration has emerged as a promising approach to identify patient subgroups. However, in terms of grouping genes (or gene products) into co-expression modules, data integration methods suffer from two main drawbacks.
Xiaoqing Chen +7 more
doaj +1 more source
Guidelines for the next 10 years of proteomics [PDF]
Proteomics 6, 1 (2006) 4-8, 2009 In the last ten years, the field of proteomics has expanded at a rapid rate. A range of exciting new technology has been developed and enthusiastically applied to an enormous variety of biological questions. However, the degree of stringency required in proteomic data generation and analysis appears to have been underestimated.
arxiv +1 more source