Results 1 to 10 of about 651,926 (331)

Biomarkers of Endometriosis

open access: yesFertility & Reproduction, 2022
Background: Endometriosis is an under-recognised and often misdiagnosed chronic disease that affects one in ten women. It occurs when cells similar to those that line a uterus grow in other parts of the body, usually around the pelvis.
Kerryn L. GARRETT   +11 more
doaj   +1 more source

Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance

open access: yesNature Communications, 2021
How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for ...
Haohao Huang   +23 more
doaj   +1 more source

The New and the Old: Platform Cross-Validation of Immunoaffinity MASS Spectrometry versus ELISA for PromarkerD, a Predictive Test for Diabetic Kidney Disease

open access: yesProteomes, 2020
PromarkerD is a proteomics derived test for predicting diabetic kidney disease that measures the concentrations of three plasma protein biomarkers, APOA4, CD5L and IBP3.
Scott Bringans   +4 more
doaj   +1 more source

Foresight in clinical proteomics: current status, ethical considerations, and future perspectives [version 1; peer review: 2 approved]

open access: yesOpen Research Europe, 2023
With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research.
Filip Mundt   +9 more
doaj   +1 more source

LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis

open access: yesNature Communications, 2021
Dynamic assembly and disassembly of primary cilia is critical for tissue development and homeostasis. Here the authors identify lysophosphatidic acid (LPA) as a physiological extracellular factor that initiates cilia disassembly through both YAP/TAZ ...
Huai-Bin Hu   +17 more
doaj   +1 more source

Foresight in clinical proteomics: current status, ethical considerations, and future perspectives [version 2; peer review: 3 approved]

open access: yesOpen Research Europe, 2023
With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research.
Filip Mundt   +9 more
doaj   +1 more source

Transcriptionally imprinted glycomic signatures of acute myeloid leukemia

open access: yesCell & Bioscience, 2023
Background Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous disease that has been suffering from stagnant survival curves for decades.
Constantin Blöchl   +4 more
doaj   +1 more source

Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease [PDF]

open access: yes, 2016
The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD.
Heerspink, Hiddo J.L.   +2 more
core   +9 more sources

Discovery and validation of a colorectal cancer classifier in a new blood test with improved performance for high-risk subjects

open access: yesClinical Proteomics, 2017
Background The aim was to improve upon an existing blood-based colorectal cancer (CRC) test directed to high-risk symptomatic patients, by developing a new CRC classifier to be used with a new test embodiment.
Lisa J. Croner   +8 more
doaj   +1 more source

Applied Proteomics in ‘One Health’

open access: yesProteomes, 2021
‘One Health’ summarises the idea that human health and animal health are interdependent and bound to the health of ecosystems. The purpose of proteomics methodologies and studies is to determine proteins present in samples of interest and to quantify ...
Eleni I. Katsarou   +5 more
doaj   +1 more source

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