Results 1 to 10 of about 505,018 (335)

Quality not Quantity: The Role of Marine Natural Products in Drug Discovery and Reverse Chemical Proteomics

Marine Drugs, 2005
Reverse chemical proteomics combines affinity chromatography with phage display and promises to be a powerful new platform technology for the isolation of natural product receptors, facilitating the drug discovery process by rapidly linking biologically ...
Andrew M. Piggott, Peter Karuso
doaj   +1 more source

Perseus: A Bioinformatics Platform for Integrative Analysis of Proteomics Data in Cancer Research.

Methods in molecular biology, 2018
Mass spectrometry-based proteomics is a continuously growing field marked by technological and methodological improvements. Cancer proteomics is aimed at pursuing goals such as accurate diagnosis, patient stratification, and biomarker discovery, relying ...
Stefka Tyanova, Jüergen Cox
semanticscholar   +1 more source

Novel Strategies to Address the Challenges in Top-Down Proteomics.

Journal of the American Society for Mass Spectrometry, 2021
Top-down mass spectrometry (MS)-based proteomics is a powerful technology for comprehensively characterizing proteoforms to decipher post-translational modifications (PTMs) together with genetic variations and alternative splicing isoforms toward a ...
Jake A. Melby, David S. Roberts, Eli J. Larson, Kyle A. Brown, Elizabeth F. Bayne, Song Jin, Ying Ge   +6 more
semanticscholar   +1 more source

Proteomics approaches: A review regarding an importance of proteome analyses in understanding the pathogens and diseases

Frontiers in Veterinary Science, 2022
Proteomics is playing an increasingly important role in identifying pathogens, emerging and re-emerging infectious agents, understanding pathogenesis, and diagnosis of diseases.
Muhammad Zubair, Jia Wang, Yanfei Yu, Yanfei Yu, Yanfei Yu, Muhammad Faisal, Mingpu Qi, Abid Ullah Shah, Zhixin Feng, Guoqing Shao, Guoqing Shao, Yu Wang, Qiyan Xiong, Qiyan Xiong, Qiyan Xiong   +14 more
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An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

Nature Communications, 2018
Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the third leading cause of death worldwide. Here, we use single cell transcriptomics and mass spectrometry-based proteomics to quantify changes in cellular ...
I. Angelidis, L. Simon, I. Fernandez, M. Strunz, C. Mayr, F. Greiffo, George Tsitsiridis, M. Ansari, E. Graf, T. Strom, Monica Nagendran, T. Desai, O. Eickelberg, M. Mann, Fabian J Theis, H. Schiller   +15 more
semanticscholar   +1 more source

Multiplexed proteomic biosensor platform for label-free real-time simultaneous kinetic screening of thousands of protein interactions

Communications Biology
Studying protein interactions in high throughput (HTP) is critical for advancing many aspects of drug discovery, biomarker identification, and diagnostic development.
Chidozie Victor Agu, Rebecca L. Cook, William Martelly, Lydia R. Gushgari, Mukilan Mohan, Bharath Takulapalli   +5 more
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Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes

Cardiovascular Diabetology, 2018
NG-Methylation of l-arginine (Arg) residues in certain proteins by protein arginine methyltransferases and subsequent proteolysis yields NG-monomethyl-l-arginine (MMA), NG,NG-dimethyl-l-arginine (asymmetric dimethylarginine, ADMA) and NG,N′G-dimethyl-l ...
Dimitrios Tsikas, Alexander Bollenbach, Erik Hanff, Arslan Arinc Kayacelebi   +3 more
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Synthesis of substituted pyridines with diverse functional groups via the remodeling of (Aza)indole/Benzofuran skeletons

Communications Chemistry, 2023
Substituted pyridines with diverse functional groups are important structural motifs found in numerous bioactive molecules. Several methodologies for the introduction of various bio-relevant functional groups to pyridine have been reported, but there is ...
Kannan Vaithegi, Sihyeong Yi, Ji Hyae Lee, Begur Vasanthkumar Varun, Seung Bum Park   +4 more
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Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics*

Molecular & Cellular Proteomics, 2013
Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease.
Linn Fagerberg, B. Hallström, P. Oksvold, C. Kampf, Dijana Djureinovic, J. Odeberg, Masato Habuka, Simin Tahmasebpoor, A. Danielsson, K. Edlund, A. Asplund, E. Sjöstedt, E. Lundberg, C. Szigyarto, Marie Skogs, Jenny Ottosson Takanen, H. Berling, Hanna Tegel, J. Mulder, P. Nilsson, J. Schwenk, C. Lindskog, Frida Danielsson, A. Mardinoğlu, Åsa Sivertsson, K. von Feilitzen, Mattias Forsberg, M. Zwahlen, Ingmarie Olsson, S. Navani, M. Huss, J. Nielsen, F. Pontén, M. Uhlén   +33 more
semanticscholar   +1 more source

Recent advances in mass spectrometry based clinical proteomics: applications to cancer research

Clinical Proteomics, 2020
Cancer biomarkers have transformed current practices in the oncology clinic. Continued discovery and validation are crucial for improving early diagnosis, risk stratification, and monitoring patient response to treatment.
A. Macklin, Shahbaz Khan, T. Kislinger
semanticscholar   +1 more source