Results 11 to 20 of about 318,547 (308)

Transcriptionally imprinted glycomic signatures of acute myeloid leukemia

open access: yesCell & Bioscience, 2023
Background Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous disease that has been suffering from stagnant survival curves for decades.
Constantin Blöchl   +4 more
doaj   +1 more source

Discovery and validation of a colorectal cancer classifier in a new blood test with improved performance for high-risk subjects

open access: yesClinical Proteomics, 2017
Background The aim was to improve upon an existing blood-based colorectal cancer (CRC) test directed to high-risk symptomatic patients, by developing a new CRC classifier to be used with a new test embodiment.
Lisa J. Croner   +8 more
doaj   +1 more source

Aldolase A promotes proliferation and G1/S transition via the EGFR/MAPK pathway in non-small cell lung cancer

open access: yesCancer Communications, 2018
Background Our previous study demonstrated that aldolase A (ALDOA) is overexpressed in clinical human lung squamous cell carcinoma and that ALDOA promotes epithelial–mesenchymal transition and tumorigenesis.
Hailu Fu   +9 more
doaj   +1 more source

Subcellular proteomics [PDF]

open access: yesNature Reviews Methods Primers, 2021
The eukaryotic cell is compartmentalized into subcellular niches, including membrane-bound and membrane-less organelles. Proteins localize to these niches to fulfil their function, enabling discreet biological processes to occur in synchrony. Dynamic movement of proteins between niches is essential for cellular processes such as signalling, growth ...
Josie A. Christopher   +14 more
openaire   +2 more sources

Sampling the proteome by emerging single-molecule and mass-spectrometry methods [PDF]

open access: yesNat Methods 20, 339--346 (2023), 2022
Mammalian cells have about 30,000-fold more protein molecules than mRNA molecules. This larger number of molecules and the associated larger dynamic range have major implications in the development of proteomics technologies. We examine these implications for both liquid chromatography-tandem mass spectrometry (LC-MS/MS) and single-molecule counting ...
arxiv   +1 more source

AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics

open access: yesNature Communications, 2022
Deep learning (DL) has been frequently used in mass spectrometry-based proteomics but there is still a lot of potential. Here, the authors develop a framework that enables building DL models to predict arbitrary peptide properties with only a few lines ...
Wen-Feng Zeng   +8 more
doaj   +1 more source

How to use 2D gel electrophoresis in plant proteomics [PDF]

open access: yesMethods in Molecular Biology -Clifton then Totowa- 1072 (2014) 43-50, 2013
Two-dimensional electrophoresis has nurtured the birth of proteomics. It is however no longer the exclusive setup used in proteomics, with the development of shotgun proteomics techniques that appear more fancy and fashionable nowadays.Nevertheless, 2D gel-based proteomics still has valuable features, and sometimes unique ones, which make it often an ...
arxiv   +1 more source

GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein

open access: yesNature Communications, 2021
Coronavirus nucleocapsid (N) protein is important for viral genome packaging and virion assembly. Here the authors show that natural chemical (-)-gallocatechin gallate (GCG) disrupts the liquid–liquid phase separation of N and inhibits SARS-CoV-2 ...
Ming Zhao   +20 more
doaj   +1 more source

Proteomes: A New Proteomic Journal [PDF]

open access: yesProteomes, 2012
In the early years of proteomics, mass spectrometry served only as a technique in protein chemistry facilitating the characterization of purified proteins and mapping their posttranslational modifications (PTMs). A bit later this technique almost completely replaced Edman degradation and amino acid analysis.
openaire   +4 more sources

Proteomics Discovery of Disease Biomarkers

open access: yesBiomarker Insights, 2008
Recent technological developments in proteomics have shown promising initiatives in identifying novel biomarkers of various diseases. Such technologies are capable of investigating multiple samples and generating large amount of data end-points. Examples
Mamoun Ahram, Emanuel F. Petricoin
doaj   +2 more sources

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