Results 21 to 30 of about 521,206 (335)
bioRxiv, 2022 Mass spectrometry-based proteomics is constantly challenged by the presence of contaminant background signals. In particular, protein contaminants from reagents and sample handling are often abundant and almost impossible to avoid.
Ashley M. Frankenfield +3 more
semanticscholar +1 more source
Molecular & Cellular Proteomics, 2002 Quantitative proteomics has traditionally been performed by two-dimensional gel electrophoresis, but recently, mass spectrometric methods based on stable isotope quantitation have shown great promise for the simultaneous and automated identification and ...
Shao-En Ong +6 more
semanticscholar +1 more source
AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
Nature Communications, 2022 Deep learning (DL) has been frequently used in mass spectrometry-based proteomics but there is still a lot of potential. Here, the authors develop a framework that enables building DL models to predict arbitrary peptide properties with only a few lines ...
Wen-Feng Zeng +8 more
doaj +1 more source
Nature Communications, 2022 Single-cell proteomics can reveal cellular phenotypic heterogeneity and cell-specific functional networks underlying biological processes. Here, we present a streamlined workflow combining microfluidic chips for all-in-one proteomic sample preparation ...
S. Gebreyesus +8 more
semanticscholar +1 more source
Nature Communications, 2021 Coronavirus nucleocapsid (N) protein is important for viral genome packaging and virion assembly. Here the authors show that natural chemical (-)-gallocatechin gallate (GCG) disrupts the liquid–liquid phase separation of N and inhibits SARS-CoV-2 ...
Ming Zhao +20 more
doaj +1 more source
A Cross-platform Toolkit for Mass Spectrometry and Proteomics
Nature Biotechnology, 2012 Mass-spectrometry-based proteomics has become an important component of biological research. Numerous proteomics methods have been developed to identify and quantify the proteins in biological and clinical samples1, identify pathways affected by ...
Matthew Chambers +42 more
semanticscholar +1 more source
Proteomes: A New Proteomic Journal [PDF]
Proteomes, 2012 In the early years of proteomics, mass spectrometry served only as a technique in protein chemistry facilitating the characterization of purified proteins and mapping their posttranslational modifications (PTMs). A bit later this technique almost completely replaced Edman degradation and amino acid analysis.
openaire +4 more sources
proteomics technologies: Probing the proteome [PDF]
Nature, 2003 The completion of the human genome sequence, coupled with analytical techniques such as mass spectrometry, has fuelled interest in proteomics. Diane Gershon reports.
openaire +3 more sources
The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics.
Mass spectrometry reviews (Print), 2020 Skyline is a freely available, open-source Windows client application for accelerating targeted proteomics experimentation, with an emphasis on the proteomics and mass spectrometry community as users and as contributors.
Lindsay K. Pino +5 more
semanticscholar +1 more source
Cytoscape stringApp: Network analysis and visualization of proteomics data
bioRxiv, 2018 Protein networks have become a popular tool for analyzing and visualizing the often long lists of proteins or genes obtained from proteomics and other high-throughput technologies.
N. Doncheva +3 more
semanticscholar +1 more source