Results 21 to 30 of about 490,947 (358)
Cancer Communications, 2018 Background Our previous study demonstrated that aldolase A (ALDOA) is overexpressed in clinical human lung squamous cell carcinoma and that ALDOA promotes epithelial–mesenchymal transition and tumorigenesis.
Hailu Fu +9 more
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The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics.
Mass spectrometry reviews (Print), 2020 Skyline is a freely available, open-source Windows client application for accelerating targeted proteomics experimentation, with an emphasis on the proteomics and mass spectrometry community as users and as contributors.
Lindsay K. Pino +5 more
semanticscholar +1 more source
Nature Reviews Methods Primers, 2021 The eukaryotic cell is compartmentalized into subcellular niches, including membrane-bound and membrane-less organelles. Proteins localize to these niches to fulfil their function, enabling discreet biological processes to occur in synchrony. Dynamic movement of proteins between niches is essential for cellular processes such as signalling, growth ...
Josie A. Christopher +14 more
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Sampling the proteome by emerging single-molecule and mass-spectrometry methods [PDF]
Nat Methods 20, 339--346 (2023), 2022 Mammalian cells have about 30,000-fold more protein molecules than mRNA molecules. This larger number of molecules and the associated larger dynamic range have major implications in the development of proteomics technologies. We examine these implications for both liquid chromatography-tandem mass spectrometry (LC-MS/MS) and single-molecule counting ...
arxiv +1 more source
Molecular & Cellular Proteomics, 2002 Quantitative proteomics has traditionally been performed by two-dimensional gel electrophoresis, but recently, mass spectrometric methods based on stable isotope quantitation have shown great promise for the simultaneous and automated identification and ...
Shao-En Ong +6 more
semanticscholar +1 more source
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
Bioinform., 2010 SUMMARY Skyline is a Windows client application for targeted proteomics method creation and quantitative data analysis. It is open source and freely available for academic and commercial use.
B. MacLean +9 more
semanticscholar +1 more source
How to use 2D gel electrophoresis in plant proteomics [PDF]
Methods in Molecular Biology -Clifton then Totowa- 1072 (2014)
43-50, 2013 Two-dimensional electrophoresis has nurtured the birth of proteomics. It is however no longer the exclusive setup used in proteomics, with the development of shotgun proteomics techniques that appear more fancy and fashionable nowadays.Nevertheless, 2D gel-based proteomics still has valuable features, and sometimes unique ones, which make it often an ...
arxiv +1 more source
ExPASy: the proteomics server for in-depth protein knowledge and analysis
Nucleic Acids Res., 2003 The ExPASy (the Expert Protein Analysis System) World Wide Web server (http://www.expasy.org), is provided as a service to the life science community by a multidisciplinary team at the Swiss Institute of Bioinformatics (SIB).
E. Gasteiger +5 more
semanticscholar +1 more source
AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
Nature Communications, 2022 Deep learning (DL) has been frequently used in mass spectrometry-based proteomics but there is still a lot of potential. Here, the authors develop a framework that enables building DL models to predict arbitrary peptide properties with only a few lines ...
Wen-Feng Zeng +8 more
doaj +1 more source
Proteomes: A New Proteomic Journal [PDF]
Proteomes, 2012 In the early years of proteomics, mass spectrometry served only as a technique in protein chemistry facilitating the characterization of purified proteins and mapping their posttranslational modifications (PTMs). A bit later this technique almost completely replaced Edman degradation and amino acid analysis.
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