Results 31 to 40 of about 521,206 (335)
Proteomics Discovery of Disease Biomarkers
Biomarker Insights, 2008 Recent technological developments in proteomics have shown promising initiatives in identifying novel biomarkers of various diseases. Such technologies are capable of investigating multiple samples and generating large amount of data end-points. Examples
Mamoun Ahram, Emanuel F. Petricoin
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Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples
Nature Communications, 2019 In-depth characterization of complex glycomes is complicated by the immense structural diversity of glycans. Here, the authors present a mass spectrometry-based strategy for untargeted, sensitive glycan profiling and identify 167 N-glycan compositions in
Guinevere S. M. Lageveen-Kammeijer +7 more
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Metabolites, 2022 Metabolism and aging are closely connected. The choline derivative glycerophosphocholine (GPC), an important precursor of the neurotransmitter acetylcholine, plays important roles in brain and nervous system function.
Jia-Yu Liu +11 more
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Proteomics technologies for cancer liquid biopsies
Molecular Cancer, 2022 Alterations in DNAs could not reveal what happened in proteins. The accumulated alterations of DNAs would change the manifestation of proteins. Therefore, as is the case in cancer liquid biopsies, deep proteome profiling will likely provide invaluable ...
Zhiyong Ding +3 more
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ProteomeXchange provides globally co-ordinated proteomics data submission and dissemination
Nature Biotechnology, 2014 223 12. Li, G.-Z. et al. Proteomics 9, 1696–1719 (2009). 13. Blackburn, K., Mbeunkui, F., Mitra, S.K., Mentzel, T. & Goshe, M.B. J. Proteome Res. 9, 3621–3637 (2010). 14. Huang, X. et al. Anal. Chem. 83, 6971–6979 (2011). 15. Geiger, T., Cox, J.
J. Vizcaíno +24 more
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Nature Reviews Methods Primers, 2021 The eukaryotic cell is compartmentalized into subcellular niches, including membrane-bound and membrane-less organelles. Proteins localize to these niches to fulfil their function, enabling discreet biological processes to occur in synchrony. Dynamic movement of proteins between niches is essential for cellular processes such as signalling, growth ...
Josie A. Christopher +14 more
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Combining LOPIT with differential ultracentrifugation for high-resolution spatial proteomics
Nature Communications, 2019 Spatial proteomics allows studying cellular protein localisations at system-wide scale. Here, the authors show that combining the previously developed hyperLOPIT method with differential centrifugation yields protein localisation maps at suborganellar ...
Aikaterini Geladaki +8 more
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Proteomics: Concepts and applications in human medicine
World Journal of Biological Chemsitry, 2021 Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell.
Safa Al-Amrani +4 more
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Neuropeptide reporter assay for serum, capillary blood and blood cards
MethodsX, 2020 In the associated main paper (JPBA 2019), substance P was shown to be a valuable neuropeptide reporter substance to monitor the protease activity of serum. The assay was developed based on the predecessor assay using bradykinin (JPBA 2017).
U. Schreiber +3 more
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Cotton proteomics: Dissecting the stress response mechanisms in cotton
Frontiers in Plant Science, 2022 The natural environment of plants comprises a complex set of biotic and abiotic stresses, and plant responses to these stresses are complex as well. Plant proteomics approaches have significantly revealed dynamic changes in plant proteome responses to ...
George Bawa +6 more
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