Results 41 to 50 of about 521,206 (335)

Spatially Resolved Mass Spectrometry at the Single Cell: Recent Innovations in Proteomics and Metabolomics

Journal of the American Society for Mass Spectrometry, 2021
Biological systems are composed of heterogeneous populations of cells that intercommunicate to form a functional living tissue. Biological function varies greatly across populations of cells, as each single cell has a unique transcriptome, proteome, and ...
Michael J Taylor, J. Lukowski, C. Anderton   +2 more
semanticscholar   +1 more source

A Direct MS-Based Approach to Profile Human Milk Secretory Immunoglobulin A (IgA1) Reveals Donor-Specific Clonal Repertoires With High Longitudinal Stability

Frontiers in Immunology, 2021
Recently, a mass spectrometry-based approach was introduced to directly assess the IgG1 immunoglobulin clonal repertoires in plasma. Here we expanded upon this approach by describing a mass spectrometry-based technique to assess specifically the clonal ...
Albert Bondt, Albert Bondt, Kelly A. Dingess, Kelly A. Dingess, Max Hoek, Max Hoek, Danique M. H. van Rijswijck, Danique M. H. van Rijswijck, Albert J. R. Heck, Albert J. R. Heck   +9 more
doaj   +1 more source

Progress of phosphorylated proteomics in breast cancer [PDF]

Yixue xinzhi zazhi, 2020
With the development of genomics, proteomics and transcriptomics, tumor research is becoming more and more systematic and in-depth. Compared with the genome, the proteome is more complex, more active and closer to the essence of life.
Yu-Jiao DENG, Na LI, Wen-Ge ZHU, Zhi-Jun DAI   +3 more
doaj   +1 more source

Sialic acid linkage differentiation of glycopeptides using capillary electrophoresis – electrospray ionization – mass spectrometry

Scientific Reports, 2017
Sialylation is a glycosylation feature that occurs in different linkages at the non-reducing end of a glycan moiety, the linkage isomers are often differentially associated with various biological processes.
Guinevere S. M. Kammeijer, Bas C. Jansen, Isabelle Kohler, Anthonius A. M. Heemskerk, Oleg A. Mayboroda, Paul J. Hensbergen, Julie Schappler, Manfred Wuhrer   +7 more
doaj   +1 more source

Identifying individuals using proteomics: are we there yet?

Frontiers in Molecular Biosciences, 2022
Multi-omics approaches including proteomics analyses are becoming an integral component of precision medicine. As clinical proteomics studies gain momentum and their sensitivity increases, research on identifying individuals based on their proteomics ...
Ivo Fierro-Monti, James C. Wright, Jyoti S. Choudhary, Juan Antonio Vizcaíno   +3 more
doaj   +1 more source

MSFragger: ultrafast and comprehensive peptide identification in shotgun proteomics

Nature Methods, 2017
There is a need to better understand and handle the 'dark matter' of proteomics—the vast diversity of post-translational and chemical modifications that are unaccounted in a typical mass spectrometry–based analysis and thus remain unidentified.
Andy T. Kong, F. V. Leprevost, D. Avtonomov, Dattatreya Mellacheruvu, A. Nesvizhskii   +4 more
semanticscholar   +1 more source

Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery

Frontiers in Medicine, 2021
Proteomics has become an important field in molecular sciences, as it provides valuable information on the identity, expression levels, and modification of proteins. For example, cancer proteomics unraveled key information in mechanistic studies on tumor
Yang Woo Kwon, Han-Seul Jo, Sungwon Bae, Youngsuk Seo, Parkyong Song, Minseok Song, J. Yoon   +6 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Application of a validated prognostic plasma protein biomarker test for renal decline in type 2 diabetes to type 1 diabetes: the Fremantle Diabetes Study Phase II

Clinical Diabetes and Endocrinology
Background There are scant data relating to prognostic biomarkers for chronic kidney disease (CKD) complicating type 1 diabetes. The aim of this study was to assess the performance of the plasma protein biomarker-based PromarkerD test developed and ...
Timothy M. E. Davis, Wendy A. Davis, Scott D. Bringans, James K. C. Lui, Tasha S. C. Lumbantobing, Kirsten E. Peters, Richard J. Lipscombe   +6 more
doaj   +1 more source

Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis

Nature Communications, 2018
Microtubule asters originate from centrosomes but their role during interphase remains largely unknown. Here, the authors find that microtubule asters anchored by previously-uncharacterized FSD1 play a role in ciliogenesis by maintaining the dynamic ...
Hai-Qing Tu, Xuan-He Qin, Zhi-Bin Liu, Zeng-Qing Song, Huai-Bin Hu, Yu-Cheng Zhang, Yan Chang, Min Wu, Yan Huang, Yun-Feng Bai, Guang Wang, Qiu-Ying Han, Ai-Ling Li, Tao Zhou, Feng Liu, Xue-Min Zhang, Hui-Yan Li   +16 more
doaj   +1 more source