Results 161 to 170 of about 98,202 (223)

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 502-510, February 2026.
ABSTRACT O‐GlcNAc transferase (OGT) and its antagonist O‐GlcNAcase (OGA) regulate protein O‐GlcNAcylation, a highly conserved post‐translational modification involved in metabolic sensing. Pathogenic variants in the OGT gene cause an X‐linked congenital disorder of glycosylation (OGT‐CDG) presenting developmental delay, hypotonia, intellectual ...
Alfonso Manuel D'Alessio, Huijie Yuan, Leandro Raul Soria, Sara Basse Hansen, Iolanda Boffa, Paola Arena, Benedetta Attianese, Maureen. O'Sullivan, Noelle Cullinan, Lewis Pang, Daan Marinus Ferdinand van Aalten, Nicola Brunetti‐Pierri, Sally Ann Lynch   +12 more
wiley   +1 more source

The long non-coding RNA UGDH-AS1 encodes an NK-cell-inhibiting micropeptide in triple-negative breast cancers. [PDF]

Nat Commun
Zhang Z, Li F, Dai X, Deng J, Guo B, Wang Y, Liu W, Pan Y, Zhao T, Wang S, Li W, Jin C, Zhang H, Zhang S, Zhou Y.   +14 more
europepmc   +1 more source

A Clinical Guidance for the Management of Patients With Hepatoid Adenocarcinoma and A Case Series

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Hepatoid adenocarcinoma (HAC) is a rare extrahepatic tumor of non‐germ cell origin that morphologically resembles hepatocellular carcinoma (HCC). HAC has a propensity to metastasize to the liver and therefore may be mistaken for HCC. There is a lack of standardized treatment protocols, and further studies are needed to evaluate the benefit of ...
Christina Liava, Sudhakar Venkatesh, Michael S. Torbenson, Patrick S. Kamath, Moira Hilscher   +4 more
wiley   +1 more source

Immunocompetent C57BL/6 syngeneic mouse ovarian cancer models with defined genetic alterations. [PDF]

Sci Rep
Agadjanian H, Karlan BY, Walsh CS, Orsulic S.   +3 more
europepmc   +1 more source

Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention

Cancer Medicine, Volume 15, Issue 2, February 2026.
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa, N. D. Amal Wageesha, Sameera R. Samarakoon, Sagarika Ekanayake, H. M. Kasuni Akalanka   +4 more
wiley   +1 more source

SOX2 confers tumour permissiveness in a specific skin progenitor population. [PDF]

Nat Commun
Centeno PP, Chester C, Kanellos G, Ford CA, Cammareri P, Inman GJ, Jamieson T, Ridgway RA, Marais R, Campbell AD, Sansom OJ.   +10 more
europepmc   +1 more source

Digital Biomarkers for Precision Early Detection of Lung Cancer: Integrating AI‐Driven Multi‐Omics Into Clinical Pathways

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide, highlighting the urgent need for earlier detection within real‐world screening and patient management pathways. Recent advances in multi‐omics technologies have created new opportunities for identifying biomarkers associated with early‐stage lung cancer ...
Fan Bu, Zhi‐Qiang Ling
wiley   +1 more source

The CCAT2 enigma: pioneering insights into colorectal cancer pathophysiology and therapeutic innovation. [PDF]

Cancer Cell Int
Fathollahzadeh M, Vanan AG, Mohammadmoradi N, Ghorbaninezhad F, Eini P, Tofighi Zavareh MA, Rahmani Y, Rostami S, Tahmasebi S, Safarzadeh E.   +9 more
europepmc   +1 more source

Incorporating Scale Uncertainty into Differential Expression Analyses Using ALDEx2

Current Protocols, Volume 6, Issue 2, February 2026.
Abstract Differential abundance or expression analyses are routinely performed on metagenomic, metatranscriptomic, and amplicon sequencing data. In such datasets, analysts usually have no information regarding the true scale (i.e., size) of the microbial community or sample under study, with inter‐sample differences in sequencing depth instead being ...
Scott J. Dos Santos, Gregory B. Gloor
wiley   +1 more source

GAB2 regulates lipid metabolism by activating the MEK/ERK/c-Myc pathway: impact on renal cell carcinoma progression. [PDF]

Eur J Med Res
Zhang W, Fei X, Qin P, Sun Y, Zhu Z, Huang N, Li X, Li Z, Liu T.   +8 more
europepmc   +1 more source