Results 11 to 20 of about 5,394 (238)

Lung Cancer: A Literature Review

open access: yesJurnal Respirasi, 2023
Lung cancer is a cancer whose onset starts in the lungs where there is an abnormal cell growth that is very fast and uncontrolled. The abnormal cell growth is triggered by deoxyribonucleic acid (DNA) damage, including deletions in the DNA section ...
Yan Efrata Sembiring   +8 more
doaj   +1 more source

O PROTO-ONCOGENE RAS NO BÓCIO MULTINODULAR

open access: yesClinical and Biomedical Research, 2022
A transformação neoplásica resulta de uma série de alterações genéticas, envolvendo ativação de proto-oncogenes e inativação de genes supressores tumorais.
Lenara Golbert   +5 more
doaj  

Molecular Pathogenesis and Targeted Therapies in Well-Differentiated Thyroid Carcinoma [PDF]

open access: yesEndocrinology and Metabolism, 2014
Four proto-oncogenes commonly associated with well-differentiated thyroid carcinoma, rearranged during transfection (RET)/papillary thyroid cancer, BRAF, RAS, and PAX8/peroxisome proliferator activated receptor-γ, may carry diagnostic and prognostic ...
Jung Guk Kim
doaj   +1 more source

Analyses of domains and domain fusions in human proto-oncogenes

open access: yesBMC Bioinformatics, 2009
Background Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers.
Wan Ping   +5 more
doaj   +1 more source

A Review on the Molecular Pathology of Epithelial Thyroid Tumors

open access: yesمجله دانشکده پزشکی اصفهان, 2018
Epithelial thyroid tumors are all from the thyrocytes, the follicular epithelial cells of the thyroid. If these cells do not replicate the normal mechanisms of growth, cell division, and apoptosis, and enter to the uncontrolled growth phase, thyroid ...
Seyedeh Adeleh Razavi   +3 more
doaj   +1 more source

Detection of Mutations in Selected Proto-Oncogenes of Canine Lymphoma

open access: yesFolia Veterinaria, 2017
Lymphomas belong among the most frequently diagnosed tumours of the haematopoietic system in dogs. The clinical manifestations and genetic and molecular basis of canine lymphoma resembles those of human non-Hodgkin lymphoma and therefore it can serve as ...
Bóna G., Šiviková K.
doaj   +1 more source

Dynamical Behaviour of a Time Delay Model of the ERK and STAT5 Interaction [PDF]

open access: yesBioautomation, 2007
In this paper we have done sensitive analysis of a time delay model which describes the ERK and STAT5 interaction. The results show that the type of the equilibrium point of the model can be a compound saddle-focus or a compound saddle-knot.
Kotev V.
doaj  

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez   +13 more
wiley   +1 more source

Expressão dos protooncogenes c-fos, c-myc e c-jun em miométrio normal e mioma humanos Expression of the protooncogenes c-fos, c-myc and c-jun in human normal miometrium and leiomyoma

open access: yesRevista Brasileira de Ginecologia e Obstetrícia, 2006
OBJETIVO: Comparar a expressão gênica (mRNA) e protéica dos protooncogenes c-fos, c-myc e c-jun em miométrio normal e mioma humanos. MÉTODOS: Foi realizado um estudo do tipo caso-controle.
Ana Luiza Ferrari   +6 more
doaj   +1 more source

USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K

open access: yesMolecular Oncology, 2022
Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK families.
Cristian Prieto‐Garcia   +14 more
doaj   +1 more source

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