Results 71 to 80 of about 3,247 (202)
ATP itself is able to undergo liquid–liquid phase separation in the presence of the macromolecular crowding agent PEG and physiological ATP concentrations are sufficient for phase separation in the presence of mM Mg2+ and crowders, mimicking intracellular conditions.
Robert Dec +2 more
wiley +1 more source
Programming Multidomain Peptides With Molecular Frustration Into Biomolecular Condensates
De novo designed multidomain peptides (MDPs) were used to explore how molecular ordering influences peptide phase behavior. MDPs containing partially folded β‐sheets were found to form biomolecular condensates. This work introduces a new design principle for condensate formation and expand the design space beyond conventional intrinsically disordered ...
Debdatta Das +12 more
wiley +1 more source
Recent Theoretical Approaches to Minimal Artificial Cells
Minimal artificial cells (MACs) are self-assembled chemical systems able to mimic the behavior of living cells at a minimal level, i.e. to exhibit self-maintenance, self-reproduction and the capability of evolution.
Fabio Mavelli +3 more
doaj +1 more source
Design of Fuel‐Dependent, Complex‐Coacervate‐Based Synthetic Cells
Fuel‐dependent synthetic cells form and persist only in the presence of chemical fuel, decaying under starvation. We establish design rules for hexapeptide‐based coacervates, showing that tryptophan enhances polyanion binding, extends lifetime, and reduces waste sensitivity.
Anna‐Lena Holtmannspötter +9 more
wiley +1 more source
Additional file 5 of Non-interfacial self-assembly of synthetic protocells
Additional file 5: video S4 Dynamic changes of 293T cells incubating with synthetic protocells in 4 ...
Xiaolin Xu (493031) +4 more
core +1 more source
Terrestrial geothermal fields and oceanic hydrothermal vents are considered as candidate environments for the emergence of life on Earth. Nevertheless, the ionic strength and salinity of oceans present serious limitations for the self-assembly of ...
Manesh Prakash Joshi +3 more
doaj +1 more source
G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation
G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang +5 more
wiley +1 more source
Role of hydrodynamic flows in chemically driven droplet division
We study the hydrodynamics and shape changes of chemically active droplets. In non-spherical droplets, surface tension generates hydrodynamic flows that drive liquid droplets into a spherical shape.
Rabea Seyboldt, Frank Jülicher
doaj +1 more source
Artificial cell: An emerging bioactive material with advanced applications in cancer theranostics
Artificial cells are emerging as attractive biomimetic bioactive materials that recapitulate key structures and functions of natural cells. This review systematically summarizes their major types, versatile fabrication strategies, tuneable properties and programmable biomimetic behaviours, highlights their cutting‐edge integrated applications in cancer
Daikun Wu, Shuo Yang, Hongjing Dou
wiley +1 more source
Antagonistic chemical coupling in self-reconfigurable host–guest protocells [PDF]
Fabrication of compartmentalised chemical systems with nested architectures and biomimetic properties has important implications for controlling the positional assembly of functional components, spatiotemporal regulation of enzyme cascades and modelling ...
Li, Mei +5 more
core +1 more source

