Results 51 to 60 of about 3,247 (202)
Advanced Science, EarlyView.This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source
Macromolecularly Crowded Protocells from Reversibly Shrinking Monodisperse Liposomes [PDF]
, 2018 The compartmentalization of cell-free gene expression systems in liposomes provides an attractive route to the formation of protocells, but these models do not capture the physical (crowded) environment found in living systems.
Yelleswarapu, V.S.M.K. +17 more
core +1 more source
Physicochemical Characterization of Polymer-Stabilized Coacervate Protocells [PDF]
, 2023 The bottom-up construction of cell mimics has produced a range of membrane-bound protocells that have been endowed with functionality and biochemical processes reminiscent of living systems.
Abdelmohsen LKEA +7 more
core +1 more source
Artificial Cell Catalysts for Biotransformation: Design Principles and Process Integration
Biotechnology and Bioengineering, EarlyView.ABSTRACT Artificial cell catalysts are emerging as programmable biocatalytic platforms for sustainable molecular conversion. By reconstituting enzymes and functional modules within synthetic compartments, they combine the selectivity of biological catalysis with the design flexibility of synthetic materials.
Iori Kobayashi +2 more
wiley +1 more source
Natural size variation amongst protocells leads to survival and growth under hypoosmotic conditions [PDF]
Membrane growth is vital to the evolution of cellular life. For model protocells, this has most commonly been shown to occur through competition between different protocell populations or with the addition of extra amphiphiles.
Natasha, Kaushik +2 more
core +2 more sources
Continuous Light-Induced Water Oxidation in Polyoxometalate-Based Photocatalytic Protocells and Prototissues. [PDF]
ChemistryThe bottom‐up construction of leaf‐like materials capable of using visible light and water to produce oxygen and chemical energy is a major goal of artificial photosynthesis. In this work, we show that robust artificial cells (protocells) prepared by the
Rebasa-Vallverdu A +6 more
europepmc +2 more sources
Negative Chemotaxis of Urease‐Functionalized Polymeric Microcapsules
Small, EarlyView.Urease‐functionalized PLGA microcapsules exhibit negative chemotaxis in urea gradients, migrating from high to low substrate concentrations. Increasing gradients enhance chemotaxis until a plateau, while increasing average substrate concentration in a fixed gradient reverses chemotactic behavior.
Amanda Hopkins +2 more
wiley +1 more source
Generic properties of dynamical models of protocells
, 2017 Models are of great importance for protocell research, not only for the usual reasons why models matter, but also because real protocells are not yet available in the lab.
Villani M. +3 more
core +1 more source
Protocells and RNA Self-Replication [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 The general notion of an "RNA world" is that, in the early development of life on the Earth, genetic continuity was assured by the replication of RNA, and RNA molecules were the chief agents of catalytic function. Assuming that all of the components of RNA were available in some prebiotic locale, these components could have assembled into activated ...
Gerald F. Joyce, Jack W. Szostak
openaire +2 more sources
Putative roles of terpenoids in primitive membranes
Frontiers in Ecology and Evolution, 2023 For the continuation and evolution of life, primitive membranes formed from prebiotically available components must have fulfilled certain essential requirements. Candidate amphiphiles, such as straight-chain fatty acids, that can self-assemble into cell-
Joshua P. King +3 more
doaj +1 more source