Results 41 to 50 of about 5,117 (196)
Advanced Science, 2022 Several immune cell‐expressed miRNAs (miRs) are associated with altered prognostic outcome in cancer patients, suggesting that they may be potential targets for development of cancer therapies.
Paco López‐Cuevas +7 more
doaj +1 more source
Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus.
PLoS ONE, 2011 We present a new antiviral strategy and research tool that could be applied to a wide range of enveloped viruses that infect human beings via membrane fusion.
Matteo Porotto +3 more
doaj +1 more source
Natural selection. III. Selection versus transmission and the levels of selection [PDF]
, 2011 George Williams defined an evolutionary unit as hereditary information for which the selection bias between competing units dominates the informational decay caused by imperfect transmission.
Frank, Steven A.
core +2 more sources
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe +5 more
wiley +2 more sources
Survival of RNA Replicators Is Much Easier in Protocells Than in Surface-Based, Spatial Systems
Life, 2019 In RNA-World scenarios for the origin of life, replication is catalyzed by polymerase ribozymes. Replicating RNA systems are subject to invasion by non-functional parasitic strands. It is well-known that there are two ways to avoid the destruction of the
Vismay Shah +4 more
doaj +1 more source
SURFACE-REACTION MODELS OF PROTOCELLS
BIOMAT 2006, 2007 We present a class of models aiming to describe generic protocells hypotheses, improving a model introduced elsewhere[13]. These models, inspired by the 'Los Alamos bug' hypothesis, are composed by two coupled subsystems: a self-replicating molecule-SRM- and a lipid container.
SERRA, Roberto, T. CARLETTI, I. POLI
openaire +5 more sources
A model of protocell based on the introduction of a semi-permeable membrane in a stochastic model of catalytic reaction networks [PDF]
, 2013 In this work we introduce some preliminary analyses on the role of a semi-permeable membrane in the dynamics of a stochastic model of catalytic reaction sets (CRSs) of molecules. The results of the simulations performed on ensembles of randomly generated
Damiani, Chiara +4 more
core +3 more sources
The pulmonary-proteoliposome as a new therapeutic approach for Coronaviruses [PDF]
, 2020 We are proposing the use of pulmonary-proteoliposome as a new therapeutic approach for Coronaviruses. The designed strategy represents a potential treatment to reduce the overall viral load in the lungs and to help the immune system to successfully stave
Feliciello, Isidoro, Procino, Alfredo
core +1 more source
Protocells and RNA Self-Replication [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 The general notion of an "RNA world" is that, in the early development of life on the Earth, genetic continuity was assured by the replication of RNA, and RNA molecules were the chief agents of catalytic function. Assuming that all of the components of RNA were available in some prebiotic locale, these components could have assembled into activated ...
Gerald F. Joyce, Jack W. Szostak
openaire +2 more sources
From molecular to cellular form: modeling the first major transition during the arising of life
BMC Evolutionary Biology, 2019 Background It has long been suggested that Darwinian evolution may have started at the molecular level and subsequently proceeded to a level with membrane boundary, i.e., of protocells.
Shaolin Yin +3 more
doaj +1 more source