Results 31 to 40 of about 5,117 (196)
The origin of heredity in protocells [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2017 Here we develop a computational model that examines one of the first major biological innovations—the origin of heredity in simple protocells. The model assumes that the earliest protocells were autotrophic, producing organic matter from CO 2 and H 2 .
West, T +3 more
openaire +4 more sources
Selfishness versus functional cooperation in a stochastic protocell model [PDF]
, 2010 How to design an "evolvable" artificial system capable to increase in complexity? Although Darwin's theory of evolution by natural selection obviously offers a firm foundation, little hope of success seems to be expected from the explanatory adequacy of ...
Agresti +56 more
core +2 more sources
Shape Deformation, Budding and Division of Giant Vesicles and Artificial Cells: A Review
Life, 2022 The understanding of the shape-change dynamics leading to the budding and division of artificial cells has gained much attention in the past few decades due to an increased interest in designing stimuli-responsive synthetic systems and minimal models of ...
Ylenia Miele +3 more
doaj +1 more source
The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. [PDF]
, 2011 Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine.
Ashley, Carlee E +20 more
core +2 more sources
Electrostatically gated membrane permeability in inorganic protocells [PDF]
, 2013 Although several strategies are now available to produce functional microcompartments analogous to primitive cell-like structures, little progress has been made in generating protocell constructs with self-controlled membrane permeability.
A Boker +30 more
core +4 more sources
Photoactivated Signaling Networks using DNA‐Based Synthetic Organelles as Biomimetic Protocells
Angewandte Chemie, EarlyView.Light‐triggered intercommunication between two types of organelle‐loaded liposomes lead to DNAzyme‐mediated on transcription‐guided structural reconfiguration of the organelles. ABSTRACT Membraneless organelles formed by phase‐separated nucleic acid or protein condensates play vital roles in regulating cellular functions.
Huiying Xue +6 more
wiley +2 more sources
Recent progress in primitive polyester synthesis and membraneless microdroplet assembly
Biophysics and Physicobiology, 2023 While it is often believed that the origins of life required participation of early biomolecules, it has been recently proposed that “non-biomolecules”, which would have been just as, if not more, abundant on early Earth, could have played a part.
Tony Z. Jia, Kuhan Chandru
doaj +1 more source
Advanced Materials Interfaces, 2023 Neuroblastoma cells can acquire resistance mechanisms that make them invulnerable to chemotherapeutic agents. The use of nanoparticles as drug carriers provides the possibility to deliver several drugs simultaneously to specific tumoral cell populations,
Jorge Parra‐Nieto +8 more
doaj +1 more source
Construction of membrane-bound artificial cells using microfluidics: a new frontier in bottom-up synthetic biology [PDF]
, 2016 The quest to construct artificial cells from the bottom-up using simple building blocks has received much attention over recent decades and is one of the grand challenges in synthetic biology.
Elani, Y
core +2 more sources
Life, 2019 Protocells are supramolecular systems commonly used for numerous applications, such as the formation of self-evolvable systems, in systems chemistry and synthetic biology.
Augustin Lopez, Michele Fiore
doaj +1 more source