Results 21 to 30 of about 3,247 (202)
Current Biology, 2020 Lai and Chen introduce the role of compartmentalization in the evolution of life.
Yei-Chen, Lai, Irene A, Chen
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Colony-like Protocell Superstructures [PDF]
Biophysical Journal, 2021 Abstract We report the formation, growth, and dynamics of model protocell superstructures on solid surfaces, resembling single cell colonies. These structures, consisting of several layers of lipidic compartments enveloped in a dome-shaped outer lipid bilayer, emerged as a result of spontaneous shape transformation of lipid agglomerates
Katke, Chinmay +5 more
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Creating complex protocells and prototissues using simple DNA building blocks
Nature Communications, 2023 Building synthetic protocells and prototissues hinges on the formation of biomimetic skeletal frameworks. Here, the authors harness simplicity to create complexity by assembling DNA subunits into structural frameworks which support membrane-based ...
Nishkantha Arulkumaran +3 more
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Life, 2023 How functional peptides may have arisen is a significant problem for the scenario of the RNA world. An attractive idea, the direct RNA template (DRT) hypothesis, proposes that RNA molecules can bind amino acids specifically and promote the synthesis of ...
Yu Shi, Chunwu Yu, Wentao Ma
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THE GROWTH OF POPULATIONS OF PROTOCELLS [PDF]
Processes of Emergence of Systems and Systemic Properties, 2008 the growth of protocells is discussed under different hypotheses (one or more replicators, linear and nonlinear kinetics) using a class of abstract models (Surface Reaction Models). A method to analyze the dynamics of successive protocell generations is presented, and it is applied to the problem of determining whether the duplication times of the ...
SERRA, Roberto +3 more
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Introduction. Artificial protocells [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2007 What makes a cell? How are cells able to replicate themselves in a stable manner? How did cellular life emerge on our planet? The answer to these fundamental questions lies at the base of biology.
Solé, Richard V. +2 more
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Non-enzymatic oligonucleotide ligation in photoswitchable coacervate protocells sustains compartment-content coupling [PDF]
, 2021 Modern cells are adaptive chemical compartments tightly regulated by an underlying DNA-encoded program. Reproducing such a coupling between information content and chassis in synthetic compartments represents a key step to the assembly of evolvable ...
Tommaso Pietro, FRACCIA, Nicolas, MARTIN
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Signal-Processing and Adaptive Prototissue Formation in Metabolic DNA Protocells [PDF]
, 2022 The fundamental life-defining processes in living cells, such as replication, division, adaptation, and tissue formation, take place via intertwined metabolic reaction networks orchestrating downstream signal processing in a confined, crowded environment
Wilfried, Weber +9 more
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Evolution of linkage and genome expansion in protocells: The origin of chromosomes.
PLoS Genetics, 2020 Chromosomes are likely to have assembled from unlinked genes in early evolution. Genetic linkage reduces the assortment load and intragenomic conflict in reproducing protocell models to the extent that chromosomes can go to fixation even if chromosomes ...
András Szilágyi +3 more
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Progress in synthesizing protocells [PDF]
Experimental Biology and Medicine, 2018 The traditional route to investigating biology by perturbing living systems or by individually purifying and characterizing component parts is giving way to more complex endeavors where chemists and physicists attempt to build cells from scratch. Parallel efforts are underway that either exploits extant biological parts or prebiotically plausible ...
Toparlak, Omer Duhan, Mansy, Sheref S.
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