Results 11 to 20 of about 3,247 (202)
Selection for replicases in protocells. [PDF]
PLoS Computational Biology, 2013 We consider a world of nucleotide sequences and protocells. The sequences have the property of spontaneous self-replication. Some sequences - so-called replicases - have enzymatic activity in the sense of enhancing the replication rate of all (or almost ...
Ginestra Bianconi +3 more
doaj +9 more sources
The origin of heredity in protocells [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2017 Here we develop a computational model that examines one of the first major biological innovations—the origin of heredity in simple protocells. The model assumes that the earliest protocells were autotrophic, producing organic matter from CO2 and H2 ...
West, T +7 more
core +7 more sources
Protocells: At the Interface of Life and Non-Life
Life, 2015 The cellular form, manifesting as a membrane-bounded system (comprising various functional molecules), is essential to life. The ultimate reason for this is that, typically, one functional molecule can only adopt one “correct” structure to perform one ...
Wentao Ma, Yu Feng
doaj +2 more sources
Bioinspired Networks of Communicating Synthetic Protocells [PDF]
Frontiers in Molecular Biosciences, 2021 The bottom-up synthesis of cell-like entities or protocells from inanimate molecules and materials is one of the grand challenges of our time. In the past decade, researchers in the emerging field of bottom-up synthetic biology have developed different ...
Patrick J. Grimes +4 more
doaj +2 more sources
Non-interfacial self-assembly of synthetic protocells
Biomaterials Research, 2023 Background Protocell refers to the basic unit of life and synthetic molecular assembly with cell structure and function. The protocells have great applications in the field of biomedical technology.
Xiaolin Xu +4 more
doaj +2 more sources
Surface Reaction Models of Protocells [PDF]
BIOMAT 2006, 2006 We present some improved versions of a previous model10 to describe a class of genericprotocells hypotheses, inspired by the “Los Alamos bug” hypothesis but which, due totheir abstraction level, can be applied to a wider set of detailed protocell ...
Carletti, Timoteo; id_orcid +9 more
core +6 more sources
Computing with Synthetic Protocells
Acta Biotheoretica, 2015 International audienceIn this article we present a new kind of computing device that uses biochemical reactions networks as building blocks to implement logic gates.
Courbet, Alexis +5 more
core +3 more sources
Multistable Protocells Can Aid the Evolution of Prebiotic Autocatalytic Sets
Life, 2023 We present a simple mathematical model that captures the evolutionary capabilities of a prebiotic compartment or protocell. In the model, the protocell contains an autocatalytic set whose chemical dynamics is coupled to the growth–division dynamics of ...
Angad Yuvraj Singh, Sanjay Jain
doaj +2 more sources
Spatially Encoded Protocell Network for Non-Cascaded Parallel Biocomputation. [PDF]
Adv Sci (Weinh)A non‐cascaded, hydrogel‐based proteinosome computational platform is developed, in which redox‐responsive proteinosomes serve as local computing units within a shared reaction–diffusion field. Reductant inputs, countered by an auxiliary glucose gradient, regulate spatially patterned proteinosome disruption, and generate population‐level boundaries ...
Wu S, Tian L.
europepmc +2 more sources
Photoactivated Signaling Networks using DNA-Based Synthetic Organelles as Biomimetic Protocells. [PDF]
Angew Chem Int Ed EnglLight‐triggered intercommunication between two types of organelle‐loaded liposomes lead to DNAzyme‐mediated on transcription‐guided structural reconfiguration of the organelles. ABSTRACT Membraneless organelles formed by phase‐separated nucleic acid or protein condensates play vital roles in regulating cellular functions.
Xue H +6 more
europepmc +3 more sources