Results 91 to 100 of about 1,827,802 (158)

Expression, purification and characterization of the human proton-coupled folate transporter [PDF]

, 2016
The human proton-coupled folated transporter (PCFT, SLC46A1) is the primary means for the absorption of dietary folates. Folates (Vitamin B9) and folate cofactors are required for more than a hundred metabolic reactions in cells including synthesis of ...
Date, Swapneeta
core  

Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats

, 2009
Objectives Methotrexate is reportedly a substrate for proton-coupled folate transporter/haem carrier protein 1 (PCFT/HCP1) and reduced folate carrier 1 (RFC1).
Tomoharu Yokooji, Nobuhiro Mori, Teruo Murakami   +2 more
core   +1 more source

Structural Characterization And Therapeutic Utility Of The Proton-Coupled Folate Transporter [PDF]

, 2016
Folate is a B9 vitamin essential to DNA synthesis. The proton-coupled folate transporter (PCFT) is a newly discovered proton/folate symporter with an acidic pH optimum and broad expression across a variety of solid tumor types, with limited expression in
Wilson, Michael Roy
core   +1 more source

Tumor Targeting with Novel 6‑Substituted Pyrrolo [2,3‑d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis

, 2016
Targeted antifolates with heteroatom replacements of the carbon vicinal to the phenyl ring in 1 by N (4), O (8), or S (9), or with N-substituted formyl (5), acetyl (6), or trifluoroacetyl (7) moieties, were synthesized and tested for selective cellular ...
Lalit K. Golani (3077712), Adrianne Wallace-Povirk (3077721), Karsten Melcher (301766), Xin Gu (244758), Sudhir Raghavan (1338405), Kathryn White (1533388), Charles E. Dann (1533391), Aleem Gangjee (1318269), Zhanjun Hou (1338402), Juiwanna Kushner (1533397), Larry H. Matherly (196065), Jennifer Wong (3077715), Jiyuan Ke (177013), Carrie O’Connor (1533394), H. Eric Xu (177044), Mike R. Wilson (571936), Lisa Polin (458535), Parker W. de Waal (3077724), Xinxin Li (281237), Siobhan M. Deis (3077718)   +19 more
core   +1 more source

Targeted Protein Degradation: From Molecular Mechanisms to Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Graphical overview of targeted protein degradation: mechanisms, molecular determinants, delivery strategies, and therapeutic development. This graphical abstract summarizes the major degradation pathways involved in targeted protein degradation, including the ubiquitin–proteasome system, endocytosis–lysosome pathway, and autophagy‐dependent degradation.
Huaijuan Guo, Haishuang Duan, Yang Liu, Kelan Fang, Lujia Xiao, Ling Bai, Xiao Qu, Xuebing Yan, Kun Zhang   +8 more
wiley   +1 more source

Folate metabolic pathway.

, 2018
Depiction of folate uptake and reduction, transmethylation, and transulfuration pathways. Genes in the shaded circles were analyzed for single nucleotide polymorphisms.
Zhongxue Chen (137919), Shirisha Chittiboyina (2393389), Barbara A. Hocevar (539956), Lisa M. Kamendulis (306718), E. Gabriela Chiorean (539963)   +4 more
core   +1 more source

Combating Campylobacter Resistance in Moroccan Poultry Using Essential Oil–Ciprofloxacin Combination

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
With an estimated prevalence of 15.52% in Moroccan poultry, Campylobacter species pose a significant food safety concern. We investigated whether essential oils (EOs) could restore the efficacy of ciprofloxacin against multidrug‐resistant (MDR) strains.
Zineb Soubai, Nadia Ziyate, Rim Rais, Hamza Elhrech, Oumayma Aguerd, Abdelhakim Bouyahya, Taoufiq Benali, Mohamed Akhazzane, Hiba Mahir, Siham Fellahi, Waleed Al Abdulmonem, Imane El Houssni, Benaissa Attarassi, Nabila Auajjar   +13 more
wiley   +1 more source

A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding

American Journal of Physiology-Cell Physiology, 2012
Proton-coupled folate transporter (PCFT) mediates folate intestinal absorption and transport across the choroid plexus, processes defective in subjects with hereditary folate malabsorption (HFM). PCFT is also widely expressed in human solid tumors where it contributes to the transport of pemetrexed and other antifolates.
Daniel Sanghoon, Shin, Rongbao, Zhao, Enghui H, Yap, Andras, Fiser, I David, Goldman   +4 more
openaire   +3 more sources

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity

Frontiers in Pharmacology
BackgroundL-Leucovorin (l-LV; 5-formyltetrahydrofolate, folinic acid) is a precursor for 5,10-methylenetetrahydrofolate (5,10-CH2-THF), which is important for the potentiation of the antitumor activity of 5-fluorouracil (5FU).
Godefridus J. Peters, Godefridus J. Peters, Ietje Kathmann, Elisa Giovannetti, Elisa Giovannetti, Kees Smid, Yehuda G. Assaraf, Gerrit Jansen   +7 more
doaj   +1 more source

A MUC13 Variant Enhances Intestinal Ferric Iron Absorption in Unexplained Hyperferritinemia

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background & Aims Hyperferritinemia frequently remains unexplained despite comprehensive evaluation. We conducted a sequencing‐based exome association study to identify genetic variants associated with plasma ferritin levels in patients with unexplained hyperferritinemia.
Jonas Callet, Yong H. Sheng, Yaowu He, Maël Silva Rodriguez, Céline Chéry, Ramia Safar, Françoise Barbé, Mouni Bensenane, Rosa‐Maria Guéant‐Rodriguez, Fares Namour, Guillaume Gauchotte, Janelle Louise Hancock, Hana Manceau, Thibaud Lefebvre, Dimitri Tchernitchko, Hervé Puy, Timothy H. Florin, Jakob Begun, John D. Hooper, Jean‐Pierre Bronowicki, Michael A. McGuckin, Jean‐Louis Guéant, Abderrahim Oussalah   +22 more
wiley   +1 more source