Results 81 to 90 of about 1,827,802 (158)

Engineering metal‐organic framework‐based smart porous nanoplatforms for targeted therapy and theranostic applications

Smart Molecules, EarlyView.
MOFs offer high porosity and tunability for biomedical applications, especially in cancer therapy via ROS generation and targeted delivery. Though toxicity, stability, and scalability remain key clinical challenges. Drug loading in MOFs exceeds 60%–70% with controlled release behavior.
Jagabandhu Bag, Subhasis Banerjee, Sabyasachi Banerjee, Sourav De, S. K. Ashok Kumar, Yan‐Jye Shyong, Subhankar Mukhopadhyay   +6 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Folates and antifolates in rheumatoid arthritis

Pteridines, 2013
Almost all current standard treatment of care for patients with chronic inflammatory diseases such as rheumatoid arthritis (RA) includes the folate antagonist methotrexate (MTX).
Jansen Gerrit, Weijers Karin, Blits Marjolein, van der Heijden Joost, Gent Yoony, Al Marjon, van der Laken Conny, Molthoff Carla, Verweij Cor, Voskuijl Alexandre, Lems Willem, Scheper Rik, Peters Godefridus, Ratnam Manohar, Aassaraf Yehuda, Dijkmans Ben   +15 more
doaj   +1 more source

Application and Research Progress of Nucleic Acid‐Based Drug Delivery Systems in the Treatment of Intracerebral Hemorrhage

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
This review summarizes recent advances in NADDS for treating ICH, highlighting the advantages and applications of key delivery technologies including lipid nanoparticles, exosomes, and DNA nanostructures. ABSTRACT Intracerebral hemorrhage (ICH) is a devastating stroke subtype associated with high mortality and neurological disability, yet effective ...
Jingyan Wang, Xuejiao Zeng, Pengyu Niu, Jinjin Shi, Wenyan Yu   +4 more
wiley   +1 more source

6‑Substituted Pyrrolo[2,3‑d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors

, 2015
2-Amino-4-oxo-6-substituted-pyrrolo­[2,3-d]­pyrimidine antifolate thiophene regioisomers of AGF94 (4) with a thienoyl side chain and three-carbon bridge lengths [AGF150 (5) and AGF154 (7)] were synthesized as potential antitumor agents.
Sudhir Raghavan (1338405), Steven Orr (1338408), Kathryn White (1533388), Charles E. Dann (1533391), Aleem Gangjee (1318269), Adrianne Wallace (1338417), Christina George (1338414), Zhanjun Hou (1338402), Si Yang (1533385), Juiwanna Kushner (1533397), Larry H. Matherly (196065), Shermaine Mitchell-Ryan (1533400), Lei Wang (6656), Carrie O’Connor (1533394), Siobhan M. Deis (1533403), Mike R. Wilson (571936), Lisa Polin (458535)   +16 more
core   +2 more sources

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source

Folate malabsorption is associated with down-regulation of folate transporter expression and function at colon basolateral membrane in rats

, 2011
Folates, an essential component (important B vitamin) in the human diet, are involved in many metabolic pathways, mainly in carbon transfer reactions such as purine and pyrimidine biosynthesis and amino acid interconversions.
Krishan Lal Khanduja, Jyotdeep Kaur, Abid Hamid, Nissar Ahmad Wani   +3 more
core   +1 more source

CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression [PDF]

, 2020
Background Cerebral folate deficiency (CFD) syndrome is characterised by a low concentration of 5-methyltetrahydrofolate in cerebrospinal fluid, while folate levels in plasma and red blood cells are in the low normal range.
Wlodarczyk, Bogdan J, Ramaekers, Vincent T; https://orcid.org/, Cao, Xuanye, Parker, Margaret, Finnell, Richard H, Han, Xiao, Zhu, Huiping, Kim, Sung-Eun, Lin, Ying, Steele, John W, Wolf, Annika, Cabrera, Robert M, Steinfeld, Robert, Lei, Yunping; https://orcid.org/, Cabrera, Robert M., Wlodarczyk, Bogdan J., Lei, Yunping, Steele, John W.   +17 more
core   +1 more source

The proton-coupled folate transporter: biology and therapeutic applications to cancer [PDF]

, 2012
Folates are essential cofactors of tumor cell proliferation and survival required for nucleotide biosynthesis and amino acid metabolism. In cancer therapy, inhibition of folate-dependent metabolic pathways has been achieved through the use of antifolates.
Desmoulin, Sita
core   +1 more source

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan, Julia Neugebauer, Marcello Bellusci, Enrico Bertini, Garry Brown, Niklas Darin, Suzanne DeBrosse, Lucy Drexler, Stefan Drexler, Gregory M. Enns, Rebecca D. Ganetzky, Kelly Gilbert, Austin Larson, Rebecca Legi, April N. Lehman, Camile Newby, Manuel Schiff, Rachel Skeath, Peter W. Stacpoole, Sarah Thompson, Emma Watt, Saskia B. Wortmann, Jirair K. Bedoyan, Shamima Rahman   +23 more
wiley   +1 more source