Results 61 to 70 of about 1,827,802 (158)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Therapeutic targeting of a novel 6-substituted pyrrolo [2,3d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter

, 2020
Non-standard abbreviations: AICARFTase, 5-amino-4-imidazolecarboxamide ribonucleotide CHO, Chinese hamster ovary cells dFBS, dialyzed fetal bovine serum DHFR, dihydrofolate reductase DPBS, Dulbecco's phosphate-buffered saline FITC, fluorescein ...
Eric Hales, Ph.D Larry H Matherly, Kathryn White, Mark Stout, Zhanjun Hou, Lei Wang, Lisa Polin, Larry H Matherly, Sita Kugel Desmoulin, Aleem Gangjee, Juiwanna Kushner, Christina Cherian   +11 more
core   +1 more source

Selective accumulation of hematoporphyrin derivative in glioma through proton-coupled folate transporter SLC46A1. [PDF]

J Clin Biochem Nutr, 2014
The mechanism of tumor-specific porphyrin accumulation is not clear. We investigated the expression of proton-coupled folate transporter SLC46A1 in glioma and aimed to clarify the relationship between tumor fluorescence and SLC46A1 expression.We confirmed the expression of SLC46A1 in surgical specimens from 24 glioma patients by immunohistochemistry ...
Takada T, Tamura M, Yamamoto T, Matsui H, Matsumura A.   +4 more
europepmc   +4 more sources

Interface‐Engineered MXene/g‐C3N4 Heterostructures for Energy and Environmental Applications

EcoEnergy, EarlyView.
This review highlights how interface engineering in MXene/g‐C3N4 heterostructures regulates charge transfer, band alignment, and surface chemistry, enabling broad applications in photocatalytic conversion, environmental remediation, energy storage, and multifunctional sensing/therapy. ABSTRACT Two‐dimensional MXene/g‐C3N4 heterostructures have recently
Feng Wang, Geng Liu, Xiaoqiang An
wiley   +1 more source

Experimentally Defined Structural Model of the Human Proton-Coupled Folate Transporter [PDF]

Biophysical Journal, 2014
Folate cofactors, Vitamin B9, play crucial roles in more than a hundred one-carbon metabolism reactions in mammalian cells. Humans cannot synthesize folates de novo and absorption through the diet is the only source of this vitamin. The proton-coupled folate transporter (PCFT) mediates this uptake in the upper small intestine by a pH-dependent process.
Date, Swapneeta, Jansen, Michaela
openaire   +1 more source

Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption

, 2010
The proton-coupled folate transporter (PCFT-SLC46A1) is required for intestinal folate absorption and is mutated in the autosomal recessive disorder, hereditary folate malabsorption (HFM). This report characterizes properties and requirements of the R376
Kris Mahadeo, Juliana Teo, Michael F. Romero, Ersin Selcuk Unal, Min-Hwang Chang, Daniel Shin, Andreas Fulterer, Rongbao Zhao, Ndeye Diop-Bove, I. David Goldman   +9 more
core   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Topology of Human Proton-Coupled Folate Transporter Expressed in E. Coli [PDF]

Biophysical Journal, 2013
The proton-coupled folate transporter (PCFT) is an important membrane protein involved in the absorption of folates in humans. Folic acid is considered a vitamin that plays important roles in crucial one carbon transfer reactions. Folates are especially important for processes where DNA synthesis is involved, as for example fetal development and cancer.
Date, Swapneeta, Duddempudi, Phaneendra K., Jansen, Michaela   +2 more
openaire   +1 more source