Results 41 to 50 of about 1,827,802 (158)

Genome-wide screening of genes involved in programming diapause in the next generation in silkworm, Bombyx mori (Lepidoptera: Bombycidae)

European Journal of Entomology, 2022
Maternal silkworms (Bombyx mori) of bivoltine strains are destined to produce either diapause or non-diapause eggs depending on environmental factors, such as, temperature and photoperiod experienced during the egg and larval stages.
Yuichi EGI, Katsuhiko SAKAMOTO
doaj   +1 more source

Identification of Tyr Residues That Enhance Folate Substrate Binding and Constrain Oscillation of the Proton-Coupled Folate Transporter (PCFT-SLC46A1)

American Journal of Physiology - Cell Physiology, 2015
Michele Visentin, Andras Fiser, I David Goldman   +2 more
exaly   +2 more sources

Homozygous mutation in the MTHFS gene may contribute to the development of cerebral folate deficiency syndrome

Reproductive and Developmental Medicine, 2020
Objective: The purpose of this study was to examine the role of rare variants in the one-carbon metabolic pathway in the etiology of the cerebral folate deficiency (CFD) syndrome.
Dharaniya Sakthivel, Yunping Lei, Xuanye Cao, Richard H Finnell   +3 more
doaj   +1 more source

Sucrose- and H+-dependent charge movements associated with the gating of sucrose transporter ZmSUT1 [PDF]

, 2010
Background: In contrast to man the majority of higher plants use sucrose as mobile carbohydrate. Accordingly proton-driven sucrose transporters are crucial for cell-to-cell and long-distance distribution within the plant body.
Koepsell H., Hedrich, Rainer Franz, Hermann Koepsell, Carpaneto, A., Geiger D., Geiger, D., Geiger, Dietmar, Hedrich, Rainer, Hedrich, R., Hedrich R., Bamberg E., Ernst Bamberg, Carpaneto A., Carpaneto, Armando, Armando Carpaneto, Koepsell, Hermann, Bamberg, Ernst, Koepsell, H., Dietmar Geiger, Bamberg, E., Rainer Hedrich, Carpaneto A, Koepsell H, Bamberg E, Hedrich R, Geiger D   +25 more
core   +2 more sources

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

The Human Proton-Coupled Folate Transporter: Determination of Conformation and Identification of the Folate-Binding Pocket [PDF]

Biophysical Journal, 2015
Folate cofactors play crucial roles in hundreds of reactions in cells including DNA and protein synthesis. The human proton-coupled folate transporter (PCFT) is the only means of absorption of dietary folates in humans. PCFT expression and function is associated with many disorders including hereditary folate malabsorption, neural tube defects, Down ...
Date, Swapneeta, Charles Chen, Cheng-Yen, Chen, Yidong, Jansen, Michaela   +3 more
openaire   +1 more source

MUTATION OF THE PROTON-COUPLED FOLATE TRANSPORTER GENE (PCFT-SLC46A1) IN TURKISH SIBLINGS WITH HEREDITARY FOLATE MALABSORPTION [PDF]

Pediatric Hematology and Oncology, 2010
Hereditary folate malabsorption (HFM) is a rare autosomal recessive disorder characterized by systemic and central nervous system folate deficiency. Turkish siblings are reported with the clinical syndrome of HFM, homozygous for deletion of 2 bases (c.204_205 delCC) within the first exon of the proton-coupled folate transporter (PCFT) gene, causing a ...
Berna, Atabay, Meral, Turker, Esra Arun, Ozer, Kris, Mahadeo, Ndeye, Diop-Bove, I David, Goldman   +5 more
openaire   +2 more sources

Fluorine-Substituted Pyrrolo[2,3‑d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis

, 2018
Novel fluorinated 2-amino-4-oxo-6-substituted pyrrolo­[2,3-d]­pyrimidine analogues 7–12 were synthesized and tested for selective cellular uptake by folate receptors (FRs) α and β or the proton-coupled folate transporter (PCFT) and for antitumor efficacy.
Manasa Ravindra (4872796), Adrianne Wallace-Povirk (3077721), Carrie O’Connor (1533394), Kathryn White (1533388), Mike R. Wilson (571936), Aleem Gangjee (1318269), Nian Tong (5147462), Lisa Polin (458535), Mohammad Karim (5147465), Zhanjun Hou (1338402), Juiwanna Kushner (1533397), Larry H. Matherly (196065)   +11 more
core   +5 more sources

Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1).

Am J Physiol Cell Physiol, 2018
The proton-coupled folate transporter (PCFT-SLC46A1) is required for folate transport across the apical membrane of the small intestine and across the choroid plexus.
Aluri S, Zhao R, Fiser A, Goldman ID.
europepmc   +2 more sources

Effect of Epigallocatechin Gallate on Drug Transport Mediated by the Proton-coupled Folate Transporter

Drug Metabolism and Pharmacokinetics, 2014
Folic acid (FA) is a water-soluble vitamin, and orally ingested FA is absorbed from the small intestine by the proton-coupled folate transporter (PCFT). In the present study, we investigated whether epigallocatechin gallate (EGCG), one of the tea catechins, affects the transport of FA by PCFT. EGCG inhibited the uptake of FA into Caco-2 cells and human
KISSEI, Maika, ITOH, Tomoo, NARAWA, Tomoya   +2 more
openaire   +2 more sources