Results 31 to 40 of about 1,827,802 (158)
Orally administered melatonin prevents lipopolysaccharide-induced neural tube defects in mice. [PDF]
PLoS ONE, 2014 Lipopolysaccharide (LPS) has been associated with adverse pregnant outcomes, including fetal demise, intra-uterine growth restriction (IUGR), neural tube defects (NTDs) and preterm delivery in rodent animals.
Lin Fu +7 more
doaj +1 more source
The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer. [PDF]
Cancer Chemother Pharmacol, 2018 This review considers the "promise" of exploiting the proton-coupled folate transporter (PCFT) for selective therapeutic targeting of cancer. PCFT was discovered in 2006 and was identified as the principal folate transporter involved in the intestinal absorption of dietary folates.
Matherly LH, Hou Z, Gangjee A.
europepmc +4 more sources
Structure Function Studies of the Proton Coupled Folate Transporter [PDF]
Biophysical Journal, 2010 Folate vitamins are essential for DNA replication and cellular proliferation. However, mammalian organisms are devoid of folate biosynthesis and rely on dietary sources to meet their metabolic requirement for folate cofactors. The proton coupled folate transporter (PCFT/SLC46A1) has been recently identified as the molecular entity responsible for ...
Nakashe, Prachi +3 more
openaire +1 more source
Novel localization of folate transport systems in the murine central nervous system
Fluids and Barriers of the CNS, 2022 Background Folates are a family of B9 vitamins that serve as one-carbon donors critical to biosynthetic processes required for the development and function of the central nervous system (CNS) in mammals.
Vishal Sangha +3 more
doaj +1 more source
Folic Acid Absorption Characteristics and Effect on Cecal Microbiota of Laying Hens
Frontiers in Veterinary Science, 2021 This experiment was conducted to investigate the characteristics of folic acid (FA) absorption in laying hens and the effect of FA supplementation on cecal microbiota.
Yan Bai +5 more
doaj +1 more source
Protective effects of pyrroloquinoline quinone in brain folate deficiency
Fluids and Barriers of the CNS, 2023 Background Folates (Vitamin B9) are critical for normal neurodevelopment and function, with transport mediated by three major pathways: folate receptor alpha (FRα), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).
Vishal Sangha +3 more
doaj +1 more source
Stereoselective Transport of Amethopterin Enantiomers by the Proton-coupled Folate Transporter
Drug Metabolism and Pharmacokinetics, 2010 Stereoselective transport of methotrexate (L-amethopterin, L-MTX) and its antipode (D-amethopterin, D-MTX) by the proton-coupled folate transporter (PCFT) was examined using PCFT-expressing HEK293 cells (PCFT-HEK293 cells). Uptake of both L-MTX and D-MTX was pH-dependent and decreased with an increase in the extracellular pH from 5.0 to 7.4.
NARAWA, Tomoya, ITOH, Tomoo
openaire +2 more sources
Frontiers in Pharmacology, 2022 Folates, provided by food, are commonly used antidepressant synergists in late-onset depression (LOD). However, increased intake of folic acid in the elderly population might lead to the accumulation of unmetabolized folic acid in the systemic ...
Hui-Zhen Li +7 more
doaj +1 more source
Pteridines, 2015 Folate receptors and transporters as well as folate enzymes play an essential role in human disease and form important targets for the treatment of immune diseases and cancer.
Jansen Gerrit, Peters Godefridus J.
doaj +1 more source
Scientific Reports, 2022 Novel therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. In addition, therapies that target unique vulnerabilities in the tumor microenvironment (TME) of EOC have largely been unrealized.
Adrianne Wallace-Povirk +15 more
doaj +1 more source