Results 51 to 60 of about 1,827,802 (158)

Mechanisms Involved in Colonic Folate Absorption and Metabolism in Humans and the Impact of Folic Acid Supplementation [PDF]

, 2021
The colon may play a significant role in the absorption of dietary and bacterially synthesized folate; however, the exact mechanisms involved in colonic folate absorption and the impact of folic acid supplementation are unclear.
Farrell, Colleen Cristita
core  

Essential Oral Single Nutritional Therapy Products for Inherited Metabolic Diseases: Evidence and Consensus Assessment Using a Modified Delphi Method. [PDF]

J Inherit Metab Dis
ABSTRACT Nutritional therapy is critical in managing inherited metabolic diseases (IMDs), and includes specialized diets and single nutritional therapy products (sNTPs) such as vitamins, cofactors, and amino acids. Many sNTPs function as medicines, but are regulated as food (e.g., food supplements), which can limit access, reimbursement, and consistent
Stolwijk NN, Penninx BMF, Bosch AM, Langeveld M, Salomons GS, Hollak CEM, Essential Nutritional Therapy Products for IMDs Consensus Group.   +6 more
europepmc   +2 more sources

Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption [PDF]

Molecular Genetics and Metabolism, 2011
Hereditary folate malabsorption (HFM) is an autosomal recessive disorder, recently shown to be due to loss-of-function mutations of the proton-coupled folate transporter (PCFT-SLC46A1), resulting in systemic and central nervous system folate deficiency. Data is emerging on the spectrum of PCFT mutations associated with this disorder.
Daniel Sanghoon, Shin, Kris, Mahadeo, Sang Hee, Min, Ndeye, Diop-Bove, Peter, Clayton, Rongbao, Zhao, I David, Goldman   +6 more
openaire   +2 more sources

Cell-free Expression of Proton-Coupled Folate Transporter in the Presence of Nanodiscs [PDF]

, 2021
Abstract The Proton-Coupled Folate Transporter (PCFT) is a transmembrane transport protein that controls the absorption of dietary folates in the small intestine. PCFT also mediates uptake of chemotherapeutically used antifolates into tumor cells.
Hoa Quynh Do, Carla M. Bassil, Elizabeth I. Andersen, Michaela Jansen   +3 more
openaire   +1 more source

Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption

, 2006
SummaryFolates are essential nutrients that are required for one-carbon biosynthetic and epigenetic processes. While folates are absorbed in the acidic milieu of the upper small intestine, the underlying absorption mechanism has not been defined.
Zhao, Rongbao, Goldman, I. David, Min, Sang Hee, Qiu, Andong, Chattopadhyay, Shrikanta, Tsai, Eugenia, Sandoval, Claudio, Akabas, Myles H., Jansen, Michaela, Sakaris, Antoinette   +9 more
core   +1 more source

Physiological responses to folate overproduction in Lactobacillus plantarum WCFS1 [PDF]

, 2010
Background Using a functional genomics approach we addressed the impact of folate overproduction on metabolite formation and gene expression in Lactobacillus plantarum WCFS1.
Vos, W.M., de, Willem M de Vos, Smid Eddy J, Eddy J Smid, Smid, E.J., Faijes Magda, Vos, R.C.H., de, Mars Astrid E, de Vos, R.C.H.., Klaus, M.J., Molenaar, D., Mars, A.E., Sebastian MJ Klaus, Molenaar, D.; id_orcid, Hanson, A.D., Wegkamp Arno, Douwe Molenaar, Astrid E Mars, Wegkamp, H.B.A., Molenaar Douwe, Klaus, S.M.J., Hanson Andrew D, Wegkamp, A., Magda Faijes, Faijes, M., Vos, W.M., Arno Wegkamp, de Vos Willem M, de Vos Ric CH, Andrew D Hanson, Klaus Sebastian MJ, Ric CH de Vos   +31 more
core   +1 more source

Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors

Frontiers in Microbiology, 2019
Microbial metabolites, including B complex vitamins contribute to diverse aspects of human health. Folate, or vitamin B9, refers to a broad category of biomolecules that include pterin, para-aminobenzoic acid (pABA), and glutamate subunits.
Melinda A. Engevik, Melinda A. Engevik, Christina N. Morra, Christina N. Morra, Daniel Röth, Kristen Engevik, Jennifer K. Spinler, Jennifer K. Spinler, Sridevi Devaraj, Sridevi Devaraj, Sue E. Crawford, Mary K. Estes, Mary K. Estes, Markus Kalkum, Markus Kalkum, James Versalovic, James Versalovic   +16 more
doaj   +1 more source

Stereoselective Recognition of Amethopterin Enantiomers by the Rat Proton-Coupled Folate Transporter

Biological & Pharmaceutical Bulletin, 2015
The stereoselective transport of methotrexate (L-amethopterin, L-MTX) and its enantiomer (D-amethopterin, D-MTX) by the rat proton-coupled folate transporter (rPCFT) were examined using rPCFT-expressing HEK293 cells. The initial rate of uptake of [3H]-L-MTX by the rPCFT followed Michaelis-Menten kinetics, with a Km value of 2.1 µM. Dixon plots revealed
Narawa, Tomoya, Yano, Toshiaki, Itoh, Tomoo   +2 more
openaire   +3 more sources

Effects of folic acid on body folate status, ovarian function, and organ indexes of offspring during embryonic stage

Frontiers in Veterinary Science
This experiment aimed to investigate the effect of dietary folic acid supplementation on maternal folate status and ovarian function in female broiler breeders.
Jianfei Zhao, Zhongqian Lu, Jialin Wu, Yufei Zhu, Yufei Zhu   +4 more
doaj   +1 more source

Identification of transcriptome and fluralaner responsive genes in the common cutworm Spodoptera litura Fabricius, based on RNA-seq

BMC Genomics, 2020
Background Fluralaner is a novel isoxazoline insecticide with a unique action site on the γ-aminobutyric acid receptor (GABAR), shows excellent activity on agricultural pests including the common cutworm Spodoptera litura, and significantly influences ...
Zhong-Qiang Jia, Di Liu, Ying-Chuan Peng, Zhao-Jun Han, Chun-Qing Zhao, Tao Tang   +5 more
doaj   +1 more source