Results 21 to 30 of about 1,827,802 (158)

The proton-coupled folate transporter: physiological and pharmacological roles. [PDF]

Curr Opin Pharmacol, 2013
Recent studies have identified the proton-coupled folate transporter (PCFT) as the mechanism by which folates are absorbed across the apical brush-border membrane of the small intestine and across the basolateral membrane of the choroid plexus into the cerebrospinal fluid.
Zhao R, Goldman ID.
europepmc   +4 more sources

Mechanistic insights into mutation in the proton-coupled folate transporter (SLC46A1) causing hereditary folate malabsorption. [PDF]

J Biol Chem
Hereditary folate malabsorption (HFM) is a rare, autosomal recessive disorder characterized by impaired intestinal absorption and impaired transport of folates across the choroid plexus into cerebral spinal fluid due to inactivating mutations in the human proton-coupled folate transporter (hPCFT) gene, which encodes the proton-coupled folate ...
Nandigrami P, Goldman ID, Fiser A.
europepmc   +3 more sources

A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation. [PDF]

J Biol Chem, 2020
The proton-coupled folate transporter (PCFT, SLC46A1) is required for folate intestinal absorption and transport across the choroid plexus. Recent work has identified a F392V mutation causing hereditary folate malabsorption. However, the residue properties responsible for this loss of function remains unknown.
Zhan HQ, Najmi M, Lin K, Aluri S, Fiser A, Goldman ID, Zhao R.   +6 more
europepmc   +4 more sources

The human proton-coupled folate transporter: Biology and therapeutic applications to cancer. [PDF]

Cancer Biol Ther, 2012
This review summarizes the biology of the proton-coupled folate transporter (PCFT). PCFT was identified in 2006 as the primary transporter for intestinal absorption of dietary folates, as mutations in PCFT are causal in hereditary folate malabsorption (HFM) syndrome.
Desmoulin SK, Hou Z, Gangjee A, Matherly LH.   +3 more
europepmc   +4 more sources

Intraluminal Behavior of Various Transporter Substrates in the Rat Gastrointestinal Tract

Journal of Pharmacy & Pharmaceutical Sciences, 2021
Purpose: The aim of this study was to evaluate the intraluminal behavior of various transporter substrates in different regions of the gastrointestinal (GI) tract.
Yusuke Tanaka, Taiki Harada, Kazuhiro Ito, Takanori Kurakazu, Satoshi Kasaoka   +4 more
doaj   +1 more source

Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer. [PDF]

Mol Pharmacol, 2018
The proton-coupled folate transporter (PCFT) is ubiquitously expressed in solid tumors to which it delivers antifolates, particularly pemetrexed, into cancer cells. Studies of PCFT-mediated transport, to date, have focused exclusively on the influx of folates and antifolates.
Zhao R, Najmi M, Aluri S, Spray DC, Goldman ID.   +4 more
europepmc   +4 more sources

The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery

Acta Pharmaceutica Sinica B, 2022
Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores. In this study, we demonstrate that the upregulated intestinal transporter (PCFT), which reaches a maximum of 12.3-fold ...
Jingyi Li, Yaqi Zhang, Miaorong Yu, Aohua Wang, Yu Qiu, Weiwei Fan, Lars Hovgaard, Mingshi Yang, Yiming Li, Rui Wang, Xiuying Li, Yong Gan   +11 more
doaj   +1 more source

Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta

EBioMedicine, 2022
Summary: Background: Due to the critical role of folates in neurodevelopment, it is important to understand potential interactions between anti-HIV drugs used during pregnancy, and folate delivery pathways in the placenta.
Julian C. Gilmore, Md. Tozammel Hoque, Wanying Dai, Haneesha Mohan, Caroline Dunk, Lena Serghides, Reina Bendayan   +6 more
doaj   +1 more source

A Role for the Proton-coupled Folate Transporter (PCFT-SLC46A1) in Folate Receptor-mediated Endocytosis [PDF]

Journal of Biological Chemistry, 2009
Recently, this laboratory identified a proton-coupled folate transporter (PCFT), with optimal activity at low pH. PCFT is critical to intestinal folate absorption and transport into the central nervous system because there are loss-of-function mutations in this gene in the autosomal recessive disorder, hereditary folate malabsorption. The current study
Rongbao, Zhao, Sang Hee, Min, Yanhua, Wang, Estela, Campanella, Philip S, Low, I David, Goldman   +5 more
openaire   +2 more sources

The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier [PDF]

Molecular Pharmacology, 2008
The reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT) are ubiquitously expressed in normal and malignant mammalian tissues and in human solid tumor cell lines. This article addresses the extent to which PCFT contributes to transport of pemetrexed and to the activities of this and other antifolates relative to RFC at ...
Rongbao, Zhao, Andong, Qiu, Eugenia, Tsai, Michaela, Jansen, Myles H, Akabas, I David, Goldman   +5 more
openaire   +2 more sources