Results 101 to 110 of about 1,827,802 (158)

Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption

Fluids and Barriers of the CNS
Healthy neurodevelopment requires adequate folates (vitamin B9), which are critical for key biosynthetic and homeostatic processes in the central nervous system (CNS).
Sara Aboulhassane, Vishal Sangha, Md. Tozammel Hoque, Reina Bendayan   +3 more
doaj   +1 more source

Vitamin B12‐Functionalized Nanogels for pH‐, and Redox‐Responsive Doxorubicin Delivery

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
A polymerizable 5′‐modified vitamin B12‐monomer enables the covalent incorporation of B12 into pH‐ and redox‐responsive nanogels for targeted doxorubicin delivery. The nanogels exhibit glutathione‐triggered drug release, potent antiproliferative activity against HT‐29 cancer cells, and strongly reduced cytotoxicity toward healthy cells.
Serife Dagdelen, Paula D. Mestizo, Marcin Mackiewicz, Agnieszka Kurdyn, Ewa Augustin, Marcin Karbarz, Felix Zelder   +6 more
wiley   +1 more source

Proton-coupled folate transporter (PCFT): molecular cloning, tissue expression patterns and the effects of dietary folate supplementation on mRNA expression in laying hens

1. The aim was to investigate the molecular characterisation and effects of dietary folate supplementation on mRNA concentrations of the proton-coupled folate transporter (PCFT) in chicken. 2.

core   +1 more source

Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for Cellular Uptake by High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier

, 2016
We previously reported the selective transport of classical 2-amino-4-oxo-6-substituted pyrrolo­[2,3-d]­pyrimidines with a thienoyl-for-benzoyl-substituted side chain and a three- (3a) and four-carbon (3b) bridge.
Shermaine Mitchell-Ryan (1533400), Lei Wang (6656), Christina Cherian (1884115), Sita Kugel Desmoulin (2110732), Aleem Gangjee (1318269), Zhanjun Hou (1338402), Larry H. Matherly (196065)   +6 more
core   +1 more source

Folate catabolites in spot urine as non-invasive biomarkers of folate status during habitual intake and folic acid supplementation. [PDF]

, 2013
Folate status, as reflected by red blood cell (RCF) and plasma folates (PF), is related to health and disease risk. Folate degradation products para-aminobenzoylglutamate (pABG) and para-acetamidobenzoylglutamate (apABG) in 24 hour urine have recently ...
Berthold Koletzko (144194), Rauh-Pfeiffer Astrid, Demmelmair Hans, Astrid Rauh-Pfeiffer, Weith, Thea, Berthold Koletzko, Weith Thea, Marola van Lipzig (282250), Rauh-Pfeiffer, Astrid, Mareile Niesser, Rauh-Pfeiffer, Astrid A. M., Wolfgang Peissner (282252), Niesser Mareile, Vaes Wouter, Peissner Wolfgang, Moretti, Diego, Hans Demmelmair (212025), Demmelmair, Hans, Diego Moretti, Vaes, Wouter, Diego Moretti (282248), Wouter Vaes (282251), van Lipzig Marola, Koletzko Berthold, van Lipzig, Marola, Astrid Rauh-Pfeiffer (282249), Hans Demmelmair, Thea Weith, Wolfgang Peissner, Moretti Diego, Koletzko, Berthold, Marola van Lipzig, Thea Weith (282247), Peissner, Wolfgang, Wouter Vaes, Niesser, Mareile, Mareile Niesser (282246)   +36 more
core   +2 more sources

Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer

, 2021
New therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. To identify new approaches for targeting EOC, metabolic vulnerabilities must be discovered and strategies for the selective delivery of ...
Matherly, Larry H, Md. Junayed Nayeen, Gangjee, Aleem, Zhanjun Hou, Larry H. Matherly, Hou, Zhanjun, Nayeen, Md Junayed, Adrianne Wallace-Povirk, Aleem Gangjee, Wallace-Povirk, Adrianne   +9 more
core   +1 more source

Abstract 2179: Targeted delivery of nanoparticulate cytochrome c into GL261 glioma cells through the proton-coupled folate transporter

, 2017
In this study we identified the proton-coupled folate transporter (PCFT) as a route for targeted delivery of drugs to glioma cells. Using the techniques of confocal imaging, western blotting, and siRNA knockdown against the PCFT (encoded by the SLC46A1 ...
Michael Inyushin, Yuriy Kucheryavykh, Kai Griebenow, Jescelica Ortiz-Rivera, Lilia Kucheryavykh, Luis Cubano, Alejandra Cruz-Montañez, Moraima Morales-Cruz   +7 more
core   +1 more source

Identification of Transport-critical Residues in a Folate Transporter from the Folate-Biopterin Transporter (FBT) Family* [PDF]

, 2010
The Synechocystis Slr0642 protein and its plastidial Arabidopsis (Arabidopsis thaliana) ortholog At2g32040 belong to the folate-biopterin transporter (FBT) family within the major facilitator superfamily. Both proteins transport folates when expressed in
Kunji, Edmund RS, Vickers, Tim J, Gregory, Jesse F, Eudes, Aymerick, Klaus, Sebastian MJ, Beverley, Stephen M, Noiriel, Alexandre, Hanson, Andrew D   +7 more
core   +1 more source

Proton-Coupled Folate Transporter as a Biomarker of Outcome to Treatment for Pleural Mesothelioma [PDF]

Pharmacogenomics, 2018
LI PETRI, Giovanna, Stella Cascioferro, PARRINO, Barbara, Godefridus J Peters, Patrizia Diana, Elisa Giovannetti   +5 more
openaire   +3 more sources

Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter

, 2009
Folates are essential for nucleic acid synthesis and required particularly in rapidly proliferating tissues, such as intestinal epithelium and hemopoietic cells.
Hausler, S, Eloranta, J J, Kullak-Ublick, G A, Hiller, C, Stieger, B, Häusler S, Stieger B, Kullak-Ublick GA, Zaïr ZM, Eloranta JJ, Hiller C   +10 more
core   +1 more source