Results 111 to 120 of about 1,827,802 (158)

Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase

, 2016
2-Amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidine antifolates with a thienoyl side chain (compounds 1–3, respectively) were synthesized for comparison with compound 4, the previous lead compound of this series.
Kathryn White (1533388), Michael F. Romero (174989), Sita Kugel Desmoulin (2110732), Min-Hwang Chang (2153545), Aleem Gangjee (1318269), Andreas Fulterer (2153551), Zhanjun Hou (1338402), Juiwanna Kushner (1533397), Larry H. Matherly (196065), Shermaine Mitchell-Ryan (1533400), Lei Wang (6656), Christina Cherian (1884115), Mark Stout (2153548), Lisa Polin (458535)   +13 more
core   +1 more source

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds. [PDF]

Br J Cancer, 2020
Li Petri G, El Hassouni B, Sciarrillo R, Funel N, Mantini G, Zeeuw van der Laan EA, Cascioferro S, Avan A, Zucali PA, Zaffaroni N, Lagerweij T, Parrino B, Smid K, Deraco M, Granchi C, Braczko A, Smolenski RT, Matherly LH, Jansen G, Assaraf YG, Diana P, Cloos J, Peters GJ, Minutolo F, Giovannetti E.   +24 more
europepmc   +1 more source

Proton-Coupled Folate Transporter [PDF]

, 2020
openaire   +1 more source

Reversible Pancytopenia and Immunodeficiency in a Patient With Hereditary Folate Malabsorption

, 2015
Mutations in SLC46A1 result in a defect of the proton coupled folate transporter (PCFT) and are the basis of hereditary folate malabsorption (HFM). Patients with HFM frequently present with neurodevelopmental delay and megaloblastic anemia.
Gruenert, Sarah Catharina, Cseh, Annamaria, Ehl, Stephan, Grünert, Sarah, Salzer, Ulrich, Erlacher, Miriam, Nosswitz, Ulrike, Lausch, Ekkehart, Niehues, Tim, Cseh, Annamaria M., Dueckers, Gregor, Speckmann, Carsten, Steinfeld, Robert, Niemeyer, Charlotte Marie   +13 more
core   +1 more source

Characterization of potential drug targeting folate transporter proteins from Eukaryotic Pathogens

, 2017
Background: Medically important pathogens are responsible for the death of millions every year. For many of these pathogens, there are limited options for therapy and resistance to commonly used drugs is fast emerging.
Mofolusho O. Falade, Benson Otarigho
core   +1 more source

Regulatory mechanisms of intestinal folate uptake in a rat model of folate oversupplementation

, 2010
Folic acid is essential for numerous biological functions, ranging from nucleotide biosynthesis to the remethylation of homocysteine. Folic acid is unable to cross the biological membranes by simple diffusion, so there exists a well-developed epithelial ...
Jyotdeep Kaur, Som Dev, Nissar Ahmad Wani   +2 more
core   +1 more source

Identification of the amino acid residue responsible for the myricetin sensitivity of human proton-coupled folate transporter. [PDF]

Sci Rep, 2019
Yamashiro T, Yasujima T, Ohta K, Inoue K, Yuasa H.   +4 more
europepmc   +1 more source

Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation. [PDF]

J Biol Chem, 2019
Aluri S, Zhao R, Lin K, Shin DS, Fiser A, Goldman ID.   +5 more
europepmc   +1 more source

Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1. [PDF]

Biochem J, 2019
Hou Z, O'Connor C, Frühauf J, Orr S, Kim S, Gangjee A, Matherly LH.   +6 more
europepmc   +1 more source

Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker. [PDF]

Biochem J, 2016
Wilson MR, Hou Z, Wilson LJ, Ye J, Matherly LH.   +4 more
europepmc   +1 more source