Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene [PDF]
Scientific Reports, 2022 In humans, disruptions in the heme biosynthetic pathway are associated with various types of porphyrias, including variegate porphyria that results from the decreased activity of protoporphyrinogen oxidase IX (PPO; E.C.1.3.3.4), the enzyme catalyzing the
Zora Novakova +11 more
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A boy with blistering of sun-exposed skin and finger shortening: the first case of Variegate Porphyria with a novel mutation in protoporphyrinogen oxidase (PPOX) gene in Iran: a case report and literature review [PDF]
Italian Journal of Pediatrics, 2022 Variegate Porphyria (VP) is an inherited rare disorder that is caused by mutations in the protoporphyrinogen oxidase (PPOX) gene. This deficiency is associated with the accumulation of porphyrins and porphyrin precursors in the body, which, in turn, can ...
Mohammad Vafaee-Shahi +3 more
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The Molecular Evolution, Structure, and Function of Coproporphyrinogen Oxidase and Protoporphyrinogen Oxidase in Prokaryotes [PDF]
Biology, 2023 Coproporphyrinogen oxidase (CgoX) and protoporphyrinogen oxidase (PgoX) catalyze the oxidation of the flexible cyclic tetrapyrrole of porphyrinogen compounds into fully conjugated, planar macrocyclic porphyrin compounds during heme biosynthesis.
Marcel Zámocký +3 more
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Heterologous expression and purification of recombinant human protoporphyrinogen oxidase IX: A comparative study. [PDF]
PLoS ONE, 2021 Human protoporphyrinogen oxidase IX (hPPO) is an oxygen-dependent enzyme catalyzing the penultimate step in the heme biosynthesis pathway. Mutations in the enzyme are linked to variegate porphyria, an autosomal dominant metabolic disease.
Zora Novakova +9 more
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Eucalyptus ESTs corresponding to the protoporphyrinogen IX oxidase enzyme related to the synthesis of heme, chlorophyll, and to the action of herbicides [PDF]
Genetics and Molecular Biology, 2005 This work was aimed at locating Eucalyptus ESTs corresponding to the PROTOX or PPO enzyme (Protoporphyrinogen IX oxidase, E.C. 1.3.3.4) directly related to resistance to herbicides that promote oxidative stress, changing the functionality of this enzyme.
Edivaldo Domingues Velini +9 more
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Virtual Screening and Bioassay of Novel Protoporphyrinogen Oxidase and p-Hydroxyphenylpyruvate Dioxygenase Dual-Target Inhibitors [PDF]
MoleculesNovel herbicide development is a challenge for weed control. Protoporphyrinogen oxidase (PPO) and p-hydroxyphenylpyruvate dioxygenase (HPPD) are two key enzymes involved in plant photosynthesis.
Panxiu Zhang +3 more
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Characteristics of murine protoporphyrinogen oxidase [PDF]
Protein Science, 1992 AbstractProtoporphyrinogen oxidase (EC 1.3.3.4) (PPO) is the penultimate enzyme of the heme biosynthetic pathway. Mouse PPO has been purified in low yield and kinetically characterized by this laboratory previously. A new more rapid purification procedure is described herein, and with this protein we detect a noncovalently bound flavin moiety.
Karen L. Proulx, Harry A. Dailey
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Computational and experimental insights into the mechanism of substrate recognition and feedback inhibition of protoporphyrinogen oxidase. [PDF]
PLoS ONE, 2013 Protoporphyrinogen IX oxidase (PPO; EC 1.3.3.4) is an essential enzyme catalyzing the last common step in the pathway leading to heme and chlorophyll biosynthesis.
Ge-Fei Hao +6 more
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INHERITANCE OF RESISTANCE TO PROTOPORPHYRINOGEN OXIDASE INHIBITOR HERBICIDES IN WILD POINSETTIA [PDF]
Planta Daninha, 2016 Weed resistance to herbicides is a major global problem for agriculture. In recent years, the increased use of herbicides, without proper planning, has led to a large increase in the number of cases of weed biotypes that are resistant to one or more ...
A.P. BRUSAMARELLO +4 more
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A Novel Single-Site Mutation in the Catalytic Domain of Protoporphyrinogen Oxidase IX (PPO) Confers Resistance to PPO-Inhibiting Herbicides [PDF]
Frontiers in Plant Science, 2019 Protoporphyrinogen oxidase (PPO)-inhibiting herbicides are used to control weeds in a variety of crops. These herbicides inhibit heme and photosynthesis in plants.
Gulab Rangani +9 more
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