Results 11 to 20 of about 5,682 (254)

The mitochondrial location of protoporphyrinogen oxidase [PDF]

European Journal of Biochemistry, 1985
Using the digitonin method and subsequent fractionation of rat liver mitochondria, protoporphyrinogen oxidase (penultimate enzyme in the heme biosynthesis pathway) was found to be closely associated with the mitochondrial inner membrane fraction.Chemical treatment with non‐specific probes (trypsin and diazobenzene sulfonate) of either intact or ...
Jean‐Charles Deybach, Vasco Da Silva, Bernard Grandchamp, Y Nordmann   +3 more
openalex   +3 more sources

Protoporphyrinogen Oxidase Inhibitor: An Ideal Target for Herbicide Discovery

CHIMIA, 2011
As the last common enzyme in the biosynthetic pathway leading to heme and chlorophyll, protoporphyrinogen oxidase (PPO; EC 1.3.3.4) is an ideal target for herbicide development.
Ge-Fei Hao, Yang Zuo, Sheng-Gang Yang, Guang-Fu Yang   +3 more
doaj   +4 more sources

Safety assessment of membrane-associated protoporphyrinogen IX oxidase from Enterobacter cloacae expressed in genetically modified crops [PDF]

GM Crops & Food
Crops tolerant to protoporphyrinogen IX oxidase (PPO)-inhibiting herbicides were developed by expressing an herbicide insensitive PPO, a membrane-associated protein from Enterobacter cloacae. E.
Cunxi Wang, Wenze Li, Matias S. Attene-Ramos, Colton Kessenich, Jennifer Calcaterra, Rong Wang, Bosong Xiang, Sergio Couoh-Cardel, Kimberly Hodge-Bell, Scott A. Saracco   +9 more
doaj   +2 more sources

Design, Synthesis and Herbicidal Activity of 5-(1-Amino-4-phenoxybutylidene)barbituric Acid Derivatives Containing an Enamino Diketone Motif [PDF]

Molecules
In continuation of our efforts to identify novel herbicide lead compounds, twenty new 5-(1-amino-4-phenoxybutylidene)barbituric acid derivatives containing an enamino diketone motif were synthesized and evaluated for their herbicidal activities.
Ke Chen, Shumin Wang, Shuyue Fu, Yuxiao Zhang, Wei Gao, Jin Liu, Rui Liu, Kang Lei   +7 more
doaj   +2 more sources

Discovery of Novel Phenoxypyridine as Promising Protoporphyrinogen Ix Oxidase Inhibitors

SSRN Electronic Journal, 2022
Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is a significant target for the discovery of novel bleaching herbicides. Starting from the active fragments of several known commercial herbicides, a series of PPO inhibitors with diphenyl ether scaffolds were designed and synthesized by substructure splicing and bioisosterism methods.
Li-xia Zhao, Jianfeng Peng, Fengyi Liu, Yue‐Li Zou, Shuang Gao, Ying Fu, Fei Ye   +6 more
openalex   +3 more sources

Glufosinate enhances the activity of protoporphyrinogen oxidase inhibitors [PDF]

Weed Science, 2020
AbstractGlufosinate inhibits glutamine synthetase (GS), a key enzyme for amino acid metabolism and photorespiration. Protoporphyrinogen oxidase (PPO) inhibitors block chlorophyll biosynthesis and cause protoporphyrin accumulation, a highly photodynamic intermediate.
Hudson Kagueyama Takano, Roland Beffa, Christopher Preston, Philip Westra, Franck E. Dayan   +4 more
openalex   +2 more sources

Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity. [PDF]

J Bacteriol, 2013
Engström P, Nguyen BD, Normark J, Nilsson I, Bastidas RJ, Gylfe A, Elofsson M, Fields KA, Valdivia RH, Wolf-Watz H, Bergström S.   +10 more
europepmc   +3 more sources

Proteomics analysis of nitrogen stress on the influence of carbon and nitrogen metabolism of flue-cured tobacco [PDF]

BMC Genomics
Nitrogen stress is the main abiotic stress factor affecting the carbon and nitrogen balance of flue-cured tobacco. Using tandem mass tag (TMT) proteomics, we identified 157 differentially expressed proteins (DEPs) under low nitrogen (LN, 60 kg/hm2; 65 ...
Xinwang Zhang, Shouhui Pan, Dong Chen, Yuqi Pan, Tianju Xu, Jinling Zhang, Yin Huang   +6 more
doaj   +2 more sources

Resistance to Protoporphyrinogen Oxidase-inhibiting Compound S23142 from Overproduction of Mitochondrial Protoporphyrinogen Oxidase by Gene Amplification in Photomixotrophic Tobacco Cells [PDF]

Bioscience, Biotechnology, and Biochemistry, 2002
Tobacco YZI-IS cells exhibit a 150-fold greater resistance to the protoporphyrinogen oxidase (Protox)-inhibiting compound, S23142, from wild-type tobacco cells. To investigate the mechanism for this S23142 resistance, the protein level, enzymatic activity, and sensitivity to S23142 in two Protox isoenzymes (plastidal and mitochondrial forms) were ...
Naohide Watanabe, Seiji Takayama, Shigeo Yoshida, Akira Isogai, Fang‐Sik Che   +4 more
openalex   +3 more sources

ZFN-mediated gene targeting of the Arabidopsis protoporphyrinogen oxidase gene through Agrobacterium-mediated floral dip transformation. [PDF]

Plant Biotechnol J, 2013
de Pater S, Pinas JE, Hooykaas PJ, van der Zaal BJ.   +3 more
europepmc   +3 more sources