Results 41 to 50 of about 5,697,775 (262)

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Identification of putative potassium channel homologues in pathogenic protozoa. [PDF]

PLoS ONE, 2012
K(+) channels play a vital homeostatic role in cells and abnormal activity of these channels can dramatically alter cell function and survival, suggesting that they might be attractive drug targets in pathogenic organisms.
David L Prole, Neil V Marrion
doaj   +1 more source

Heat shock protein 90 from neglected protozoan parasites

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
Significant advances have been made in our understanding of heat shock protein 90 (Hsp90) in terms of its structure, biochemical characteristics, post-translational modifications, interactomes, regulation and functions. In addition to yeast as a model several new systems have now been examined including flies, worms, plants as well as mammalian cells ...
Roy, Nainita, Nageshan, Rishi Kumar, Ranade, Shatakshi, Tatu, Utpal   +3 more
openaire   +3 more sources

Proteomic Identification of Oxidized Proteins in Entamoeba histolytica by Resin-Assisted Capture: Insights into the Role of Arginase in Resistance to Oxidative Stress. [PDF]

PLoS Neglected Tropical Diseases, 2016
Entamoeba histolytica is an obligate protozoan parasite of humans, and amebiasis, an infectious disease which targets the intestine and/or liver, is the second most common cause of human death due to a protozoan after malaria.
Preeti Shahi, Meirav Trebicz-Geffen, Shruti Nagaraja, Sharon Alterzon-Baumel, Rivka Hertz, Karen Methling, Michael Lalk, Serge Ankri   +7 more
doaj   +1 more source

Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites

Parasites & Vectors, 2011
Apoptosis-like programmed cell death (PCD) has recently been described in multiple taxa of unicellular protists, including the protozoan parasites Plasmodium, Trypanosoma and Leishmania.
Reece Sarah E, Sajid Mohammed, Kaczanowski Szymon   +2 more
doaj   +1 more source

The stage-regulated HASPB and SHERP proteins are essential for differentiation of the protozoan parasite Leishmania major in its sand fly vector, Phlebotomus papatasi

Cellular Microbiology, 2010
The stage‐regulated HASPB and SHERP proteins of Leishmania major are predominantly expressed in cultured metacyclic parasites that are competent for macrophage uptake and survival. The role of these proteins in parasite development in the sand fly vector
J. Sádlová, H. Price, Barbara A. Smith, J. Votýpka, P. Volf, Deborah F. Smith   +5 more
semanticscholar   +1 more source

Proteomic analysis of the ventral disc of Giardia lamblia

BMC Research Notes, 2012
Background Giardia lamblia is a multiflagellated protozoan that inhabits the small intestine of vertebrates, causing giardiasis. To colonize the small intestine, the trophozoites form of the parasite remains attached to intestinal epithelial cells by ...
Lourenço Daniela, Andrade Iamara, Terra Letícia, Guimarães Patricia, Zingali Russolina, de Souza Wanderley   +5 more
doaj   +1 more source

Genomic Databases and the Search of Protein Targets for Protozoan Parasites [PDF]

Current Drug Targets, 2009
The development of databases devoted to biological information opened the possibility to integrate, query and analyze biological data obtained from several sources that otherwise would be scattered through the web. Several issues arise in the handling of biological information, mainly due to the diversity of biological subject matter and the complexity
Luís Fernando S M, Timmers, Ivani, Pauli, Guy Barros, Barcellos, Kelen Beiestorf, Rocha, Rafael Andrade, Caceres, Walter Filgueira, de Azevedo, Milena Botelho Pereira, Soares   +6 more
openaire   +2 more sources

Identification and Characterization of a Protozoan Uncoupling Protein in Acanthamoeba castellanii [PDF]

Journal of Biological Chemistry, 1999
An uncoupling protein (UCP) has been identified in mitochondria from Acanthamoeba castellanii, a nonphotosynthetic soil amoeboid protozoon that, in molecular phylogenesis, appears on a branch basal to the divergence points of plants, animals, and fungi. The existence of UCP in A.
Jarmuszkiewicz, Wieslawa, Sluse-Goffart, Claudine, Hryniewiecka, L., Sluse, Francis   +3 more
openaire   +3 more sources

Characterization of a novel association between two trypanosome-specific proteins and 5S rRNA. [PDF]

PLoS ONE, 2012
P34 and P37 are two previously identified RNA binding proteins in the flagellate protozoan Trypanosoma brucei. RNA interference studies have determined that the proteins are essential and are involved in ribosome biogenesis.
Martin Ciganda, Noreen Williams
doaj   +1 more source